Two‐Stage Recipient Hepatectomy and Left Liver Transplantation to Minimize Risks in Adult‐to‐Adult Living Donor Liver Transplantation: New Concepts

Coubeau, Laurent; Iesari, Samuele; Ciccarelli, Olga; Bonaccorsi‐Riani, Eliano; Dahlqvist, Géraldine; Reding, Raymond

doi:10.1002/lt.25683

Cited by 9 publications

(3 citation statements)

References 8 publications

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“…Of the German patients, three patients were alive without tumor recurrence within 6 to 18 mo of follow-up; one patient died of pulmonary embolism at 24 mo post transplantation, with tumor recurrence in the thoracic vertebral body, skull and bilateral lung but not the liver at the fifth month[ 53 ]. No recurrence or death occurred at 180 d according to published data[ 52 ]. In the Oslo group, 3 patients underwent DD-RAPID transplantation, and one died of hepatic artery thrombosis and sepsis 40 d post operation.…”

Section: Advances In Lt Surgery For Crlmmentioning

confidence: 92%

“…Eleven patients with unresectable CRLM, specifically eight patients with LD-RAPID (five in Germany, two in Italy, and one in Belgium), had undergone RAPID surgery using deceased donor (DD) grafts and living donor (LD) grafts by the end of 2019[ 52 ]. Of the German patients, three patients were alive without tumor recurrence within 6 to 18 mo of follow-up; one patient died of pulmonary embolism at 24 mo post transplantation, with tumor recurrence in the thoracic vertebral body, skull and bilateral lung but not the liver at the fifth month[ 53 ].…”

Section: Advances In Lt Surgery For Crlmmentioning

confidence: 99%

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Advances in liver transplantation for unresectable colon cancer liver metastasis

Chen¹,

Geng²,

Zhou³

et al. 2021

WJGS

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It is estimated that 50% of patients with colorectal cancer will develop liver metastasis. Surgical resection significantly improves survival and provides a chance of cure for patients with colorectal cancer liver metastasis (CRLM). Increasing the resectability of primary unresectable liver metastasis provides more survival benefit for those patients. Considerable surgical innovations have been made to increase the resection rate and decrease the potential risk of hepatic failure postoperation. Liver transplantation (LT) has been explored as a potential curative treatment for unresectable CRLM. However, candidate selection criteria, chemotherapy strategies, refined immunity regimens and resolution for the shortage of grafts are lacking. This manuscript discusses views on surgical indication, peritransplantation anti-tumor and anti-immunity therapy and updated advances in LT for unresectable CRLM. A literature review of published articles and registered clinical trials in PubMed, Google Scholar, and Clinicaltrials.gov was performed to identify studies related to LT for CRLM. Some research topics were identified, including indications for LT for CRLM, oncological risk, antitumor regimens, graft loss, administration of anti-immunity drugs and solutions for graft deficiency. The main candidate selection criteria are good patient performance, good tumor biological behavior and chemosensitivity. Chemotherapy should be administered before transplantation but is not commonly administered posttransplantation for preventive purposes. Mammalian target of rapamycin regimens are recommended for their potential oncological benefit, although there are limited cases. In addition to extended criterion grafts, living donor grafts and small grafts combined with two-stage hepatectomy are efficient means to resolve organ deficiency. LT has been proven to be an effective treatment for selected patients with liver-only CRLM. Due to limited donor grafts, high cost and poorly clarified oncological risks, LT for unresectable CRLM should be strictly performed under a well-organized study plan in selected patients. Some vital factors, like LT indication and anti-tumor and anti-immune treatment, remain to be confirmed. Ongoing clinical trials are expected to delineate these topics.

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Section: Advances In Lt Surgery For Crlmmentioning

confidence: 92%

Section: Advances In Lt Surgery For Crlmmentioning

confidence: 99%

Advances in liver transplantation for unresectable colon cancer liver metastasis

Chen¹,

Geng²,

Zhou³

et al. 2021

WJGS

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show abstract

“…The concept has been further developed by retrieving the left lateral graft from living donors. To date, 6 two-stage hepatectomies with auxiliary partial orthotopic liver transplantation from a living donor (named LD-RAPID) have been reported: 5 in Germany [41,42] and 1 in Belgium [43]. The first results are promising, but still the experience with the RAPID concept is limited and does not yet allow firm conclusions.…”

Section: Negative Predictive Factorsmentioning

confidence: 99%

Liver Transplantation for Colorectal Liver Metastasis

2020

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Purpose of Review Accumulating evidence suggest that selected patients with nonresectable liver only metastases from colorectal cancer can be offered liver transplantation with acceptable outcome. This review provides an update on the scientific literature. Recent Findings The SECA-I study showed an estimated 5-year survival of 60% in a heterogenous patient population and guided the development of the first clinical selection criteria. In the sequel SECA-II trial, an estimated 5-year survival of 83% was obtained. A recent study shows that an Oslo score of 0–2, a metabolic tumor volume below 70 cm3 on PET-CT or Fong score of 0–2 at time of listing, can stratify patients with superior survival. Recurrence is common, but about 70% are slow-growing lung metastases, whereof the majority are resectable. Summary Liver transplantation for colorectal liver metastasis is an option in highly selected patients. Futile use of grafts can be avoided by applying stringent selection criteria.

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Liver transplantation for neuroendocrine neoplasms liver metastases

Coubeau,

Bonaccorsi-Riani

2025

Transplant Oncology

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Two‐Stage Recipient Hepatectomy and Left Liver Transplantation to Minimize Risks in Adult‐to‐Adult Living Donor Liver Transplantation: New Concepts

Cited by 9 publications

References 8 publications

Advances in liver transplantation for unresectable colon cancer liver metastasis

Advances in liver transplantation for unresectable colon cancer liver metastasis

Liver Transplantation for Colorectal Liver Metastasis

Liver transplantation for neuroendocrine neoplasms liver metastases

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