Two-stage treatment of a tectal ganglioglioma: Endoscopic third ventriculostomy followed by surgical resection

Cultrera, Francesco; Guiducci, Graziano; Nasi, Maria Teresa; Paioli, G.; Frattarelli, Massimo

doi:10.1016/j.jocn.2005.09.011

Cited by 7 publications

(3 citation statements)

References 22 publications

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“…3 The brainstem is an unusual location for ganglioglioma with only 46 reported cases. [4][5][6][7][8] Brainstem gangliogliomas typically present with gradually evolving neurological dysfunction over several months or years, reflecting the generally indolent nature of this tumour. 4 Gangliogliomas have no pathognomic radiological features.…”

Section: Discussionmentioning

confidence: 99%

Pontomedullary ganglioglioma: A rare tumour in an unusual location

Westwood

MacFarlane

2009

Journal of Clinical Neuroscience

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Section: Discussionmentioning

confidence: 99%

Pontomedullary ganglioglioma: A rare tumour in an unusual location

Westwood

MacFarlane

2009

Journal of Clinical Neuroscience

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“…To our knowledge, there are only a limited number of reported cases, and in nearly half of them, the diagnosis was made at autopsy. [1][2][3]7,12,17,19 Seizure is considered the major clinical symptom in about 85% of cases, especially in temporal lobe gangliogliomas. Symptoms of increased intracranial pressure are unusual.…”

Section: Discussionmentioning

confidence: 99%

Brainstem gangliogliomas: a retrospective series

Zhang¹,

Wang²,

Liu³

et al. 2013

JNS

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“…[6][7][8]Given the paucity of information regarding TG in published studies, its management and prognostic factors remain ambiguous, and few studies have systematically summarized the clinical outcome of TG patients treated with ETV. [4,[9][10][11][12]]Therefore, we retrospectively reviewed patients whose preoperative imaging manifestations were consistent with low-grade TG and who underwent ETV in our institute. The goal of this study was to evaluate the risk factors for progression-free survival (PFS), elucidate the radiological features of TG, and propose a treatment protocol based on 50 TG patients who received ETV treatment.…”

Section: Introductionmentioning

confidence: 99%

Surgical Management and Prognostic Factors Based on 50 Tectal Plate Gliomas

Kang

Zhao

et al. 2020

Preprint

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BackgroundThe management and prognostic factors of tectal glioma (TG) remain ambiguous, because it is an extremely rare neoplasm that occurs predominantly in the pediatric population. The objective of this study was to evaluate the risk factors for progression-free survival (PFS) in TG patients after ETV operation, elucidate the radiological features of TG, and propose a treatment protocol.MethodsFrom 2002 to 2018, 50 patients that preoperative imaging manifestations were low-grade TGs were treated at our institute. Clinical features, treatments, radiologic findings, biopsies, and pertinent risk factors were evaluated.ResultsA total of 50 patients with a diagnosis of TG were identified. Twenty-six (52%) patients were males. The median age at diagnosis was 11.5 years (range 0.5–19 years). All patients had symptoms related to obstructive hydrocephalus and were treated with endoscopic third ventriculostomy (ETV). After a median follow-up duration of 59 months (range 11.0–208.0 months), progression occurred in six patients (12%), with a median PFS time of 18.0 months (range 4.0–56.0 months). Twelve patients (24%) underwent a biopsy, one patient (8.3%) was diagnosed with anaplastic oligodendroglioma, one patient (8.3%) was diagnosed with astrocytoma (WHO grade II-III), five patients (41.7%) were diagnosed with pilocytic astrocytoma, and the type of tumor could not be confirmed in five patients (41.7%) due to the small amount of tumor sample, thus, these patients were diagnosed with gliosis. PFS rates at 1 and 5 years were 91.2% ± 4.2% and 84.9% ± 5.9%, respectively. A multivariate model demonstrated that a large tumor size and cystic changes are risk factors for progression.ConclusionETV has been uniformly successful in the management of hydrocephalus caused by TG. A large tumor size and cystic changes are risk factors for progression. Under the condition of safety, a biopsy should be performed. For patients with low-grade TG, ETV is often the only surgical procedure that most patients require.HighlightsTectal gliomas are generally low-grade gliomas with a favorable prognosis.The only surgical procedure that most patients with tectal glioma require is ETV.Under the condition of safety, neuroendoscopy for a pathological diagnosis should be performed.A large tumor size and cystic changes are risk factors for progression.

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Two-stage treatment of a tectal ganglioglioma: Endoscopic third ventriculostomy followed by surgical resection

Cited by 7 publications

References 22 publications

Pontomedullary ganglioglioma: A rare tumour in an unusual location

Pontomedullary ganglioglioma: A rare tumour in an unusual location

Brainstem gangliogliomas: a retrospective series

Surgical Management and Prognostic Factors Based on 50 Tectal Plate Gliomas

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