Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue

Andersen, Claus Yding; Rosendahl, Mikkel; Byskov, Anne Grete; Loft, Anne; Ottosen, Christian; Dueholm, Margit; Schmidt, K.L.T.; Andersen, Anders Nyboe; Ernst, Erik

doi:10.1093/humrep/den244

Cited by 430 publications

(326 citation statements)

References 20 publications

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“…Similarly, analysis of tumors, TNM classification and tumor characteristics (receptors and proliferation index) did not suggest any correlation between an aggressive tumor and positive qPCR results in the ovary. Nevertheless, some teams allow transplantation of frozen-thawed ovarian tissue from patients with early-stage breast cancer [2,23,33,37]. However, while most breast cancer recurrences manifest within 10 years of the initial diagnosis, the disease can recur much later, emphasizing the need for long-term surveillance in clinical follow-up of these patients [7].…”

Section: Discussionmentioning

confidence: 99%

Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study

Luyckx

Durant

Camboni

et al. 2013

J Assist Reprod Genet

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Section: Discussionmentioning

confidence: 99%

Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study

Luyckx

Durant

Camboni

et al. 2013

J Assist Reprod Genet

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“…Thus, favorable result of cryopreservation in 2M DMSO was shown when DMSO and propanediol of various concentrations were compared [37]. Live births after human ovarian cortex cryopreservation and autotransplantation have been reported with either DMSO [38] or ethylene glycol [39] as CPA.…”

Section: Discussionmentioning

confidence: 99%

Whole sheep ovary cryopreservation: evaluation of a slow freezing protocol with dimethylsulphoxide

Milenković

Wallin

Ghahremani

et al. 2010

J Assist Reprod Genet

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“…One ovary was excised prior to gonadotoxic treatment and the cortical tissue was prepared and cryopreserved as previously described [12,13]. The indications for fertility preservation were breast cancer (n = 20), Hodgkin lymphoma (n = 2), nonHodgkin lymphoma (n = 2), cervix cancer (n = 4), sarcoma (n = 3), hematological disease (n = 3), and autoimmune disease (n = 1) and Premature menopause (n = 1) (Supplementary Table 1).…”

Section: Patientsmentioning

confidence: 99%

Vitrification of in vitro matured oocytes collected from surplus ovarian medulla tissue resulting from fertility preservation of ovarian cortex tissue

Yin

Jiang

Kristensen

et al. 2016

J Assist Reprod Genet

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Purpose The aim of the study was to investigate the maturation rate of immature oocytes collected from ovarian medulla tissue normally discarded during preparation of ovarian cortical tissue for fertility preservation. Further we evaluated survival of derived MII oocytes following vitrification and warming. Methods 36 patients aged from 8 to 41 years who had one ovary excised for fertility preservation were included. Oocytes were collected from the medulla tissue and matured in vitro 44-48 h followed by vitrification. Number of oocytes collected, the rates of maturation and post-warming survival were assessed. Results On average, 11 immature oocytes were collected per patient. The overall maturation rate was 29 % irrespective of whether the ovary was transported 4-5 h on ice or obtained immediately after oophorectomy. The maturation rate in patients below 20 years of age (55 %) was significantly higher than that of patients aged 20-30 years (29 %) and above 30 years (26 %). The post-warming survival rate was 64 %. No significant relationship was observed between the number of collected oocytes and the age of patients.Conclusions Approximately three MII oocytes were obtained per patient following in vitro maturation (IVM) of immature oocytes collected from medulla tissue, of which two survived vitrification and warming. This approach represents an add-on method to potentially augment the fertility opportunity for cancer patients, especially in young women with cancer where transplantation of cortical tissue may pose a risk of relapse, but the IVM approach is currently too inefficient to be the only method used for fertility preservation.

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Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue

Abstract: Two additional healthy children have been born as a result of the ovarian cryopreservation procedure. In both cases, the ovarian tissue was transported 4-5 h prior to freezing demonstrating that hospitals may offer cryopreservation without having the necessary expertise locally.

Cited by 430 publications

References 20 publications

Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study

Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study

Whole sheep ovary cryopreservation: evaluation of a slow freezing protocol with dimethylsulphoxide

Vitrification of in vitro matured oocytes collected from surplus ovarian medulla tissue resulting from fertility preservation of ovarian cortex tissue

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