Two, three, and four-drug regimens for HIV post-exposure prophylaxis in a North American sexual assault victim population

Kumar, T. Pavan; Sampsel, Kari; Stiell, Ian G.

doi:10.1016/j.ajem.2017.05.054

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…Previous data suggest higher rates of HIV PEP completion post-sexual assault are associated with fewer HIV PEP drugs in a given regimen. Post-sexual assault patients prescribed with a two drug regimen were less likely to stop HIV PEP due to side effects as compared to a three drug regimen (Garcia et al, 2005) and those on either two or three drug regimens had higher rates of completion than those on a four drug regimen (Kumar et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“Reclaiming Control” Patient Acceptance and Adherence to HIV Post-Exposure Prophylaxis Following Sexual Assault

Moret

Sheridan

2021

Global Qualitative Nursing Research

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Sexual assault is an irrefutable trauma; an insult to the autonomy of the person forced into sexual acts. Sexual assault sequelae range from physical injury and acute traumatic stress, to pregnancy and sexually transmitted infections, including human immunodeficiency virus (HIV). HIV post-exposure prophylaxis (HIV PEP) following sexual assault may decrease the likelihood of HIV transmission. Many patients seeking healthcare post-sexual assault either do not initiate HIV PEP or do not complete the 28-day medication regimen. In this qualitative interpretive description, we interviewed sexual assault patients ( N=11) about HIV PEP discussions/reactions, attitudes and understanding related to HIV and PEP, and barriers and facilitators of HIV PEP acceptance and adherence. Participants described a process of losing and reclaiming control throughout post-assault care and follow-up; and how this affected HIV PEP-related decision-making. Most HIV PEP decisions were described as a process of reclaiming control over one outcome while simultaneously losing control of another.

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Section: Discussionmentioning

confidence: 99%

“Reclaiming Control” Patient Acceptance and Adherence to HIV Post-Exposure Prophylaxis Following Sexual Assault

Moret

Sheridan

2021

Global Qualitative Nursing Research

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“…Although most PEP guidelines recommend a three-drug regimen, there is no evidence to suggest that a three or more drug regimen is superior to a two-drug regimen. 23…”

Section: Discussionmentioning

confidence: 99%

Occupational blood and body fluid exposures and human immunodeficiency virus post-exposure prophylaxis amongst intern doctors

Aigbodion

Motara

Laher

2019

Southern African Journal of HIV Medicine

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BackgroundHealthcare workers (HCWs) are constantly vulnerable to occupational blood and body fluid exposures (OBBFEs). Exposed HCWs experience emotional, physical and psychological trauma. Less experienced HCWs, such as intern doctors, are more prone to OBBFEs.ObjectivesThe aim of this study was to investigate the prevalence and practices pertaining to OBBFEs amongst a select group of intern doctors in the Gauteng province of South Africa.MethodsA quantitative cross-sectional descriptive study using a questionnaire based on a practical model was used. Intern doctors were recruited from four major hospitals in Gauteng.ResultsA total of 175 intern doctors participated in the study. There was a total of 182 (mean = 1.04, standard deviation [s.d] 0.88) reported OBBFEs amongst 136 (77.7%) subjects. The exposures occurred predominantly whilst subjects were working in surgery (n = 50, 27.5%), obstetrics and gynaecology (n = 49, 26.9%) and internal medicine (n = 48, 26.4%) departments; were superficial wounds (n = 69, 37.9%); were acquired during vascular puncture or intravenous line insertion (n = 69, 37.9%); and occurred when subjects were working >12 h shifts (n = 101, 55.5%). Human immunodeficiency virus (HIV) post-exposure prophylaxis (PEP) was initiated in 141 (77.5%) out of the 182 exposures. Only 90 (63.8%) subjects completed the recommended 28-day course of PEP. Two (1.1%) subjects reported that they had acquired HIV infection as a consequence of the OBBFE.ConclusionOccupational blood and body fluid exposures are common amongst intern doctors. It is recommended that regular training, health education and monitoring compliance should be incorporated during the induction of medical intern doctors in hospitals. The availability of PEP regimens with better tolerability will encourage compliance.

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“…These findings might have been contributed to by ARVs with fewer side-effects and prescriptions of smaller daily doses. It is important that, if possible, health facilities prioritize prescriptions with fewer daily pills and that cause fewer side effects, in order to promote greater adherence [3,26]. In addition, it is essential that health professionals mention the sideeffects which might emerge during prophylaxis.…”

Section: Discussionmentioning

confidence: 99%

Adherence to HIV post-exposure prophylaxis in a specialized service in São Paulo, Brazil

Silva

Duarte²,

Nichiata

2023

J Infect Dev Ctries

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Introduction: The effectiveness of human immunodeficiency virus (HIV) post-exposure prophylaxis (PEP) depends on adherence to the protocol, which includes taking antiretrovirals (ARVs) and attending visits. We examined the adherence rate to antiretroviral agents and follow-up visits identifying the associated characteristics of adherence and the reasons for not attending HIV PEP consultations in a specialized service in São Paulo, Brazil. Methodology: This was a cross-sectional study with health service users who had an indication for PEP due to sexual exposure in an HIV/AIDS service from April to October 2019. The health service users were followed-up throughout the prophylaxis cycle. Adherence was determined through self-reports on antiretroviral agent use and attendance to follow-up consultations. Results: Association measures were employed to identify adherence-related characteristics. The sample analyzed included 91 users. The mean age was 32.5 years old (SD = 9.8). The largest share was white-skinned (49.5%), men who have sex with other men (62.2%), male (86.8%), and undergraduate/graduate students (65.9%). Adherence totaled 56.7% and health insurance was the associated characteristic (p = 0.039). Work (55.9%), using a private service (15.2%), forgetfulness (11.8%) and considering follow-up unnecessary (11.8%) were the main reasons for not attending the follow-up appointments. Conclusions: Few users do attend HIV PEP consultations. The users without health insurance had the highest adherence percentage whereas work was mentioned as a reason for not attending HIV PEP consultations.

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Two, three, and four-drug regimens for HIV post-exposure prophylaxis in a North American sexual assault victim population

Cited by 6 publications

References 21 publications

“Reclaiming Control” Patient Acceptance and Adherence to HIV Post-Exposure Prophylaxis Following Sexual Assault

“Reclaiming Control” Patient Acceptance and Adherence to HIV Post-Exposure Prophylaxis Following Sexual Assault

Occupational blood and body fluid exposures and human immunodeficiency virus post-exposure prophylaxis amongst intern doctors

Adherence to HIV post-exposure prophylaxis in a specialized service in São Paulo, Brazil

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