2023
DOI: 10.1002/dc.25261
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Two‐tier subclassification of the Bethesda category III (atypia of undetermined significance/follicular lesion of undetermined significance) in thyroid cytology

Jay Alden,
Denise Lambrou,
Jack Yang

Abstract: BackgroundThe Bethesda category III, AUS/FLUS, comprises a heterogeneous group of thyroid lesions with variable risk of malignancy (ROM). This study evaluates ROM in two subgroups of this category based on nuclear atypia and architectural atypia.MethodsCases in Bethesda category III were reported based on nuclear atypia (AUS) and architectural atypia (FLUS). ROM was calculated by comparing the cytologic diagnosis to the follow‐up histologic diagnosis.ResultsAmong the 610 Bethesda category III cases in this stu… Show more

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