Two Types of Aggression Are Differentially Related to Serotonergic Activity and the A779C TPH Polymorphism.

Hennig, Juergen; Reuter, Martin; Netter, Petra; Burk, Caitlin M.; Landt, Olfert

doi:10.1037/0735-7044.119.1.16

Cited by 87 publications

(51 citation statements)

References 55 publications

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“…The putative reason for an elevated cortisol response is an upregulation or sensitization of postsynaptic receptors, caused by a habitually diminished serotonin release (Hennig et al, 2005). Within this line of reasoning, our results support Depue's theory, which postulates that a reduced serotonergic functionality lowers the threshold for response elicitation, which, in turn, should manifest in temperamental traits (Depue and Collins, 1999).…”

Section: Discussionsupporting

confidence: 78%

Acute responsivity of the serotonergic system to S-citalopram and positive emotionality – The moderating role of the 5-HTTLPR

Wielpuetz

Kuepper

Grant

et al. 2014

Personality and Individual Differences

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According to the idea that the central serotonergic system has a modulatory function on behavior and personality in general, we aimed to highlight its association to habitual positive emotionality. In a placebo-controlled double-blind and randomized cross-over neuroendocrine challenge design (n = 72 healthy males) we investigated the association of the central serotonergic responsivity, 5-HTTLPR-genotype as well as their combined effects on positive emotionality. Regression analyses revealed an involvement of the serotonergic system in positive emotionality. There was, however, no direct association between positive emotionality and cortisol responses to S-citalopram; rather 5-HTTLPR-genotype showed an association (p < 0.05). That is, positive emotionality scores increased with the number of s-alleles carried by the individuals. Most notable was the moderating role of 5-HTTLPR-genotype (p < 0.05) on the association between acute serotonergic responsivity and positive emotionality. Indeed, this association was only found in ss-homozygotes, in which the acute responsivity of the serotonergic system additionally seems to contribute to the level of positive emotionality (r = 0.70, p < 0.05). The findings correspond to previous research demonstrating that the 5-HTTLPR is not only involved in the negative-emotional aspects of behavior and temperament, but is associated, moreover, with positive affectivity-supporting the assumption of its valence-neutrality. In addition, our data are in line with the idea of possible influences of the 5-HTTLPR-genotype on early neuronal development. They also indicate the need for further studies in order to clearly elucidate the role of the serotonergic system and its subcomponents in the regulation of positive emotionality.

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Section: Discussionsupporting

confidence: 78%

Acute responsivity of the serotonergic system to S-citalopram and positive emotionality – The moderating role of the 5-HTTLPR

Wielpuetz

Kuepper

Grant

et al. 2014

Personality and Individual Differences

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“…Survey studies (e.g., Hennig et al, 2005;R. Martin et al, 2000) have shown relations between Neuroticism and an angry type of aggression.…”

Section: Discussionmentioning

confidence: 99%

Personality and aggressive behavior under provoking and neutral conditions: A meta-analytic review.

Bettencourt

Talley

Benjamin

et al. 2006

Psychological Bulletin

552

432

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The authors conducted a comprehensive review to understand the relation between personality and aggressive behavior, under provoking and nonprovoking conditions. The qualitative review revealed that some personality variables influenced aggressive behavior under both neutral and provocation conditions, whereas others influenced aggressive behavior only under provocation. Studies that assessed personality variables and that directly measured aggressive behavior were included in the quantitative review. Analyses revealed that trait aggressiveness and trait irritability influenced aggressive behavior under both provoking and neutral conditions but that other personality variables (e.g., trait anger, Type A personality, dissipation-rumination) influenced aggressive behavior only under provoking conditions. The authors discuss possible relations between these patterns of aggressive behavior and the personality dimensions of Agreeableness and Neuroticism and consider implications for theories of aggression.Keywords: aggressive behavior, personality traits, Agreeableness, NeuroticismWith a few notable exceptions (e.g., Freud, 1929Freud, /1962, early theorizing and research on aggressive behavior focused on the effects of situational factors (e.g., Bandura, 1973;Dollard, Doob, Miller, Mowrer, & Sears, 1939). Empirical studies and metaanalytic reviews have shown that the presence of violent cues (e.g.,

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“…In a related study, Hennig et al [43] were able to identify variations of the tryptophan hydroxylase gene, which, if linked with specific individuals, could explain the lower levels of serotonin in the brain and thus account for heightened expressions of aggressive behavior. Indeed, utilizing healthy male subjects, these authors were able to identify several nucleotide polymorphisms of the tryptophan hydroxylase gene, one of which was then correlated with high levels of the aggressive hostility factor as determined from the Buss-Durkee and related inventory scales.…”

Section: Serotoninmentioning

confidence: 99%

The Neurobiological Bases for Development of Pharmacological Treatments of Aggressive Disorders

Siegel

Bhatt²,

Bhatt³

et al. 2007

125

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Violence and aggression are major causes of death and injury, thus constituting primary public health problems throughout much of the world costing billions of dollars to society. The present review relates our understanding of the neurobiology of aggression and rage to pharmacological treatment strategies that have been utilized and those which may be applied in the future. Knowledge of the neural mechanisms governing aggression and rage is derived from studies in cat and rodents. The primary brain structures involved in the expression of rage behavior include the hypothalamus and midbrain periaqueductal gray. Limbic structures, which include amygdala, hippocampal formation, septal area, prefrontal cortex and anterior cingulate gyrus serve important modulating functions. Excitatory neurotransmitters that potentiate rage behavior include excitatory amino acids, substance P, catecholamines, cholecystokinin, vasopressin, and serotonin that act through 5-HT2 receptors. Inhibitory neurotransmitters include GABA, enkephalins, and serotonin that act through 5-HT1 receptors. Recent studies have demonstrated that brain cytokines, including IL-1 and IL-2, powerfully modulate rage behavior. IL-1 exerts its actions by acting through 5-HT2 receptors, while IL-2 acts through GABAA or NK1 receptors. Pharmacological treatment strategies utilized for control of violent behavior have met with varying degrees of success. The most common approach has been to apply serotonergic compounds. Others included the application of antipsychotic, GABAergic (anti-epileptic) and dopaminergic drugs. Present and futures studies on the neurobiology of aggression may provide the basis for new and novel treatment strategies for the control of aggression and violence as well as the continuation of existing pharmacological approaches.

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Two Types of Aggression Are Differentially Related to Serotonergic Activity and the A779C TPH Polymorphism.

Cited by 87 publications

References 55 publications

Acute responsivity of the serotonergic system to S-citalopram and positive emotionality – The moderating role of the 5-HTTLPR

Acute responsivity of the serotonergic system to S-citalopram and positive emotionality – The moderating role of the 5-HTTLPR

Personality and aggressive behavior under provoking and neutral conditions: A meta-analytic review.

The Neurobiological Bases for Development of Pharmacological Treatments of Aggressive Disorders

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