Two Types of Ca Channels in Smooth Muscle Cells Isolated from Guinea-Pig Taenia Coli

Yabu, Hideyo; Yamada, Masami; Someya, Tetsufumi; Totsuka, Morio

doi:10.1007/978-1-4684-5679-0_14

Cited by 8 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In other studies, it was shown that extracellular cadmium inhibits Ach-induced contractions by modulation muscarinic receptors, which is possible through direct interactions with channel proteins [37]. It has also been shown that cadmium-blocked, voltage-sensitive calcium channels are blocked by cadmium [38][39][40][41].…”

Section: Discussionmentioning

confidence: 94%

Cadmium Reduces Contractile Responses of Rat Duodenum, In Vitro

Koç

Koçak

Akçıl

2008

Biol Trace Elem Res

View full text Add to dashboard Cite

The present study focuses on the effects of cadmium in drinking water on rat duodenum contractility, in vitro. Two experimental groups (n = 10 each) were administered with 15 ppm cadmium chloride in their drinking water for 1 and 2 months, respectively. Two separate groups (n = 10 each) were maintained in similar conditions but received no cadmium and acted as controls. After the experimental period, the duodenal segment responses were measured by means of an isotonic transducer. The average peak amplitude of acetylcholine-induced contractions was significantly decreased in both cadmium-treated groups. Incubation of duodena from the cadmium-free controls with atropine or in a calcium-free medium resulted in reduced contractility that was undistinguishable from that of the cadmium-treated rats. Cadmium reduces the contractile response apparently by directly or indirectly decreasing cellular calcium influx.

show abstract