Two wheel-shaped Pr(III) and Er(III) complexes with long flexible ligand: Crystal structure, fluorescence and anticancer studies

Zhu, Mingchang; Wu, Shuangyan; Zhang, Ying; Ji, Xiaoxi; Qing, Chen; Gao, Enjun

doi:10.1016/j.inoche.2020.108270

Cited by 6 publications

(2 citation statements)

References 33 publications

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“…[ 57 ] The IC 50 values show that complex 1 exhibited a higher inhibitory effect than the other complexes, while it was clearly observed that complex1–3 displayed almost nontoxicity to colorectal normal cells at test concentration and time, suggesting that these complexes are relatively biocompatible. [ 58 ]…”

Section: Resultsmentioning

confidence: 99%

Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4‐phenylene‐bis [methylene])‐bis (pyridine‐3‐carboxylicaicd): Synthesis, structural characterization, and antitumor activity

Liu

et al. 2021

Applied Organom Chemis

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In this work, three new complexes [Ln2(L)3·H2O]n (where Ln = Nd(1)、Eu (2) and Sm (3)) have been synthesized by H2L (H2L = 1,1 ‘(1,4‐phenylene‐ bis [methylene])‐bis (pyridine‐3‐carboxylicaicd)) and were characterized by X‐ray single crystal diffraction and PXRD. The interaction of these complexes with FS DNA (fish sperm DNA) and the DNA binding constants of the complexes were determined using UV spectroscopy, indicating their ability to bind to FS DNA. The DNA binding constants k of the three complexes were 1.0186 × 104, 5.047 × 103, and 5.115 × 103, respectively. The results of UV spectrum showed that the complex 1–3 was bound to DNA through hydrogen bonding. The interaction of the complexes with FS DNA was studied by fluorescence spectroscopy. The stern‐volmer quenching values of complexes 1, 2, and 3 were 0.186, 0.093, and 0.114, respectively. Electrophoresis experiments showed that the three complexes could cleave DNA molecules. In addition, flow cytometry, and morphological apoptosis studies showed that the complex could induce apoptosis of HeLa tumor cells. Results all the three complexes had potential medicinal value.

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Section: Resultsmentioning

confidence: 99%

Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4‐phenylene‐bis [methylene])‐bis (pyridine‐3‐carboxylicaicd): Synthesis, structural characterization, and antitumor activity

Liu

et al. 2021

Applied Organom Chemis

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“…When the ligand is flexible, the reaction conditions can act on its mode of coordination to give highly variable coordination geometries. Several Ln(III) coordination compounds with novel topologies have been produced using flexible ligands [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectroscopic and X-Ray Structure Determination of a New Mononuclear Terbium (III) Complex from the Ligand N,N'-1,5-bis(pyridylmethylidene) Carbonohydrazone (H2L)

Seck

Gueye

Thiam

et al. 2022

EJCS

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In the title compound, [Tb(H2L)2(H2O)3].3Cl.4(H2O).(C2H5OH), the Tb3+ is nine-coordinated in a distorted monocapped square antiprismgeometry by four nitrogen atoms, two oxygen atoms from the ligand molecules of the tridentate N,N'-1,5-bis(pyridylmethylidene) carbonohydrazone) (H2L) and three oxygen atoms of coordinating water molecules. The structure of the complex was elucidated by X-ray diffraction analysis. Suitable crystals were grown by slow evaporation of ethanol solution. The compound crystallizes in the triclinic crystal system with a space group of Pī. The asymmetric unit of the compound contains two neutral ligand molecules, oneterbium ion, three coordinated water molecules, five and half uncoordinated water molecules and one uncoordinated ethanol molecule. In the crystal, the complex cations are linked by hydrogen bonds into layers. These layers, chloride anions and non-coordinating water molecules are connected by O—H···O, O—H···N, O—H···Cl, N—H···O, N—H···Cl and C—H···Cl hydrogen bonds into a three-dimensional structure.

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DNA binding studies and in-vitro anticancer studies of novel lanthanide complexes

Zhang,

Li,

et al. 2024

International Journal of Biological Macromolecules

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Two wheel-shaped Pr(III) and Er(III) complexes with long flexible ligand: Crystal structure, fluorescence and anticancer studies

Cited by 6 publications

References 33 publications

Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4‐phenylene‐bis [methylene])‐bis (pyridine‐3‐carboxylicaicd): Synthesis, structural characterization, and antitumor activity

Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4‐phenylene‐bis [methylene])‐bis (pyridine‐3‐carboxylicaicd): Synthesis, structural characterization, and antitumor activity

Synthesis, Spectroscopic and X-Ray Structure Determination of a New Mononuclear Terbium (III) Complex from the Ligand N,N'-1,5-bis(pyridylmethylidene) Carbonohydrazone (H2L)

DNA binding studies and in-vitro anticancer studies of novel lanthanide complexes

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