Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies

Arasi, Stefania; Otani, Iris M.; Klingbeil, Erik; Bégin, Philippe; Kearney, Clare; Dominguez, Tina; Block, Whitney; O’Riordan, Geraldine; Nadeau, Kari

doi:10.1186/1710-1492-10-57

Cited by 45 publications

(37 citation statements)

References 28 publications

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“…Studies in patients and parents have demonstrated a general positive effect of OIT on some aspects of QoL, especially food anxiety and social and dietary limitation but not emotional impact . Certain characteristics seem to be associated with greater improvements in caregiver QoL: in a prospective randomized study, QoL improved more in caregivers of participants older than 10 years or desensitized to more than 4 food allergens than those who were not …”

Section: Results From the Selected Literaturementioning

confidence: 99%

Anxiety and food allergy: A review of the last two decades

Polloni

Muraro

2020

Clin Experimental Allergy

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Food allergy (FA) is recognized as a growing public health burden affecting 5%‐10% of children worldwide. Several unique features specific to FA elicit high levels of emotional distress and anxiety in patients and caregivers, the first among all the possibility of a life‐threatening reaction. Anxiety disorders are highly prevalent in patients with chronic disease, but remain undertreated despite significant negative consequences on patient health. This review aimed to offer a comprehensive overview of literature data on FA and anxiety of the last two decades. A review of the medical and psychological literature from the year 2000 (MEDLINE, PubMed and PsycINFO) was done using the keywords “anxiety” and “food allergy.” Clinical implications for disease management, various manifestations in different target groups, proper interventions and possible explanations on the nature of the association between FA and anxiety have been discussed, as well as limitations and further research directions. The relationship between FA and anxiety is attributed to FA‐specific fears and anxiety, rather than a general propensity towards anxiety. Some anxiety—short‐lived and related to key events–is to be expected and may even be helpful if it sustains allergen avoidance and preparedness to emergency. However, some data reported that increased anxiety did not improve adherence. Rather, high levels of anxiety have been demonstrated counterproductive and related to maladaptive coping. Further research is needed to elucidate the association between FA and anxiety, especially to understand biopsychosocial directions of the underlying mechanisms and to build proper, effective, standardized protocols of intervention. Clinicians must be aware of the association between FA and anxiety, understand their role in recognizing maladaptive anxiety and encouraging to seek psychological support when needed.

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Section: Results From the Selected Literaturementioning

confidence: 99%

Anxiety and food allergy: A review of the last two decades

Polloni

Muraro

2020

Clin Experimental Allergy

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“…Also these studies showed that it did improve quality of life for families who have children with food allergy [5].…”

Section: Oral Immunotherapymentioning

confidence: 98%

Emerging Approaches to Food Desensitization in Children

Hamad

Burks

2017

Curr Allergy Asthma Rep

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Recent advancements in epicutaneous, sublingual, and oral immunotherapy for food allergy in the future may offer children with food allergy and their families a viable option to reduce risk or severity of anaphylaxis with phase III trials ongoing for two of these treatment modalities. Food allergy prevalence in children is estimated to be up to 8%. These children are at risk of significant allergic reactions and anaphylaxis. Food avoidance and use of antihistamines or epinephrine has been the standard of care for these patients. This approach also has a significant socioeconomic effects on patients and their families. Recent advancements in understanding food allergy have allowed for exploring new methods of treatment. There is an increasing interest in oral immunotherapy, epicutaneous immunotherapy, or sublingual immunotherapy for food allergy. There have been also innovative approaches to immunotherapy by modification of food allergens (to make them less allergenic while maintain their immunogenicity) or adding adjunctive treatments (probiotics, anti-IgE, etc.) to increase efficacy or safety.

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“…Furthermore, the impact on quality of life needs to be better elucidated . FA is associated with a negative impact on the quality of life of patients and their families . To buy special foods, to limit social encounters, to lose time from work, to change careers, and to visit emergency room have been reported to play a predominant role in the total annual economic burden of FA …”

Section: Issues For Clinical Practicementioning

confidence: 99%

“…On the other side, OIT, though logistically demanding and with side effects, might lead to significant and long‐term improvements in health‐related quality of life of patients and their caregivers …”

Section: Issues For Clinical Practicementioning

confidence: 99%

“…86 FA is associated with a negative impact on the quality of life of patients and their families. 87,88 To buy special foods, to limit social encounters, to lose time from work, to change careers, and to visit emergency room have been reported to play a predominant role in the total annual economic burden of FA. 87,88 On the other side, OIT, though logistically demanding and with side effects, might lead to significant and long-term improvements in health-related quality of life of patients and their caregivers.…”

Section: Issue S For Clini C Al Pr Ac Ti Cementioning

confidence: 99%

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Allergen immunotherapy for IgE‐mediated food allergy: There is a measure in everything to a proper proportion of therapy

Pajno

Castagnoli

Muraro³

et al. 2019

Pediatric Allergy Immunology

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IgE‐mediated food allergy (FA) is a potentially life‐threatening condition with a negative impact on quality of life and an increasing prevalence in westernized countries in the recent two decades. A strict avoidance of the triggering food(s) represents the current standard approach. However, an elimination diet may be difficult and frustrating, in particular for common foods, (eg, milk, egg, and peanut). Food allergy immunotherapy (FA‐AIT) may provide an active treatment that enables to increase the amount of food that the patient can intake without reaction during treatment (ie, desensitization), and reduces the risk of potential life‐threatening allergic reaction in the event of accidental ingestion. However, several gaps need still to be filled. A memorable Latin orator stated: “Est modus in rebus” (Horace, Sermones I, 1, 106‐07). This sentence remembers that there is a measure in everything to a proper proportion of therapy. The common sense of measure should find application in each stage of treatment. A personalized approaching should consider the specific willing and features of each patient. Efforts are devoted to improve the efficacy, the safety but also the quality of life of patients suffering from FA. In the near future, it will be important to clarify immunologic pathways of FA‐AIT, and to identify reliable biomarkers in order to recognize the most suitable candidates to FA‐AIT and algorithms for treatments tailored on well‐characterized subpopulations of patients.

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Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies

Cited by 45 publications

References 28 publications

Anxiety and food allergy: A review of the last two decades

Anxiety and food allergy: A review of the last two decades

Emerging Approaches to Food Desensitization in Children

Allergen immunotherapy for IgE‐mediated food allergy: There is a measure in everything to a proper proportion of therapy

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