Two-year outcome of MCI subtypes and aetiologies in the Goteborg MCI study

Nordlund, Arto; Rolstad, Sindre; Klang, Ola; Edman, Åke; Hansen, Stefan; Wallin, Anders

doi:10.1136/jnnp.2008.171066

Cited by 107 publications

(107 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results might suggest that, contrary to the classical understanding of a-MCI as a risk factor for dementia, the a-sd-MCI subtype is in fact a "benign" form of MCI. This challenging idea was posed by Nordlund et al (2010) in an excellent investigation. The authors evaluated the 2-year outcome in a sample composed of a-sd-MCIs, a-md-MCIs, na-sdMCIs, and na-md-MCIs.…”

Section: Discussionmentioning

confidence: 99%

MEG spectral analysis in subtypes of mild cognitive impairment

López

Cuesta

Garcés

et al. 2014

AGE

View full text Add to dashboard Cite

Mild cognitive impairment (MCI) has been described as an intermediate stage between normal aging and dementia. Previous studies characterized the alterations of brain oscillatory activity at this stage, but little is known about the differences between single and multidomain amnestic MCI patients. In order to study the patterns of oscillatory magnetic activity in amnestic MCI subtypes, a total of 105 subjects underwent an eyes-closed resting-state magnetoencephalographic recording: 36 healthy controls, 33 amnestic single domain MCIs (a-sd-MCI), and 36 amnestic multidomain MCIs (a-md-MCI). Relative power values were calculated and AGE (2014) compared among groups. Subsequently, relative power values were correlated with neuropsychological tests scores and hippocampal volumes. Both MCI groups showed an increase in relative power in lower frequency bands (delta and theta frequency ranges) and a decrease in power values in higher frequency bands (alpha and beta frequency ranges), as compared with the control group. More importantly, clear differences emerged from the comparison between the two amnestic MCI subtypes. The a-md-MCI group showed a significant power increase within delta and theta ranges and reduced relative power within alpha and beta ranges. Such pattern correlated with the neuropsychological performance, indicating that the a-md-MCI subtype is associated not only with a "slowing" of the spectrum but also with a poorer cognitive status. These results suggest that a-md-MCI patients are characterized by a brain activity profile that is closer to that observed in Alzheimer disease. Therefore, it might be hypothesized that the likelihood of conversion to dementia would be higher within this subtype.

show abstract

Section: Discussionmentioning

confidence: 99%

MEG spectral analysis in subtypes of mild cognitive impairment

López

Cuesta

Garcés

et al. 2014

AGE

View full text Add to dashboard Cite

show abstract

“…1 However, several longitudinal epidemiologic studies have found that transition from an MCI diagnosis back to normal cognition is fairly common. [2][3][4][5][6][7][8][9] Estimates of transition from MCI back to normal cognition have been quite varied, ranging from 4% to 15% [2][3][4][5] in clinic-based studies and 29% to 55% 6 -9 in population-based studies, depending in part on duration of follow-up. To date, few, if any, studies have focused on the subset of subjects who return to normal cognition after an MCI diagnosis.…”

mentioning

confidence: 99%

Reversion from mild cognitive impairment to normal or near-normal cognition

2012

View full text Add to dashboard Cite

Objectives:We sought to identify characteristics of individuals with mild cognitive impairment (MCI) that are associated with a relatively high probability of reverting back to normal cognition, and to estimate the risk of future cognitive decline among those who revert. Methods:We first studied 3,020 individuals diagnosed with MCI on at least 1 visit to an Alzheimer's Disease Center in the United States. All underwent standardized Uniform Data Set evaluations at their first visit with an MCI diagnosis and on a subsequent visit, about 1 year later, at which cognitive status was reassessed. Multiple logistic regression was used to identify predictors of reverting from MCI back to normal cognition. We then estimated the risk of developing MCI or dementia over the next 3 years among those who had reverted, compared with individuals who had not had a study visit with MCI.Results: About 16% of subjects diagnosed with MCI reverted back to normal or near-normal cognition approximately 1 year later. Five characteristics assessed at the first MCI visit contributed significantly to a model predicting a return to normal cognition: Mini-Mental State Examination (MMSE) score, Clinical Dementia Rating (CDR) score, MCI type, Functional Activities Questionnaire (FAQ) score, and APOE ⑀4 status. Survival analysis showed that the risk of retransitioning to MCI or dementia over the next 3 years was sharply elevated among those who had MCI and then improved, compared with individuals with no history of MCI.Conclusions: Even in a cohort of patients seen at dementia research centers, reversion from MCI was fairly common. Nonetheless, those who reverted remained at increased risk for future cognitive decline. Neurology Mild cognitive impairment (MCI) is often regarded as an intermediate state on a one-way path from normal cognition to dementia.1 However, several longitudinal epidemiologic studies have found that transition from an MCI diagnosis back to normal cognition is fairly common. 2-9Estimates of transition from MCI back to normal cognition have been quite varied, ranging from 4% to 15% 2-5 in clinic-based studies and 29% to 55% 6 -9 in population-based studies, depending in part on duration of follow-up. To date, few, if any, studies have focused on the subset of subjects who return to normal cognition after an MCI diagnosis. With increasing emphasis on the need to treat incipient dementia at an early stage, 10 it will be important to know which individuals with MCI have a favorable prognosis.The present study had 2 main aims. First, we sought to identify factors associated with increased likelihood of reverting from MCI to normal cognition. We hypothesized that factors that have previously been found to be associated with the progression from MCI to dementia would have the opposite association with the probability of reversion from MCI to normal cognition. We also From the

show abstract

“…Тща-тельное изучение проблемы УКН позволяет утверждать, что большинство таких расстройств гетерогенны [8]; это определяется различными патогенетическими механизма-ми их развития, морфологическими проявлениями, осо-бенностями клинической картины и исходов [9][10][11]. Представление об УКН как о продромальной стадии БА было подтверждено исследованиями, которые показали, что когнитивная недостаточность может предшествовать и другим типам деменции, в частности СД, особенно связан-ной с патологией малых сосудов [12].…”

unclassified

“…Кро-ме основных вариантов, предлагается также выделять диз-регуляторный тип УКН, при этом подчеркивается его связь с цереброваскулярной патологией [14]. Ряд авторов указывает, что преобладающим в структуре УКН является вариант с множественным поражением когнитивных функций [11]. Каждый вариант обладает определенной за-кономерностью развития.…”

unclassified

“…Каждый вариант обладает определенной за-кономерностью развития. В то время как амнестическая форма часто является начальным этапом БА, УКН с мно-жественным когнитивным дефицитом могут трансформи-роваться как в БА, так и в СД, а неамнестические формы УКН чаще переходят в СД [11,13]. Нейровизуализацион-ные исследования больных в стадии УКН свидетельствуют о том, что при амнестическом типе наблюдаются измене-ния, характерные для БА, а при неамнестическом -в ос-новном сосудистые изменения [15,16].…”

unclassified

See 1 more Smart Citation

Value of determining the cerebrospinal fluid protein markers of amyloidosis and neurodegeneration in the diagnosis of vascular and neurodegenerative cognitive impairments

Lobzin

Emelin

Odinak

et al. 2013

Neurology, Neuropsychiatry, Psychosomatics

View full text Add to dashboard Cite

Когнитивные нарушения (КН), особенно, демен-ция -одна из наиболее частых причин инвалидизации пациентов самого разного возраста. В структуре КН до-минирующую роль играют болезнь Альцгеймера (БА) и сосудистая деменция (СД). Данная проблема находится в сфере интересов не только неврологов, но и врачей об-щей практики, терапевтов, психиатров, гериатров. Это связано как с увеличением продолжительности жизни и экономическим ростом, так и с улучшением качества ме-дицинского обслуживания, развитием мультидисципли-нарного подхода. Отмечается увеличение распростра-ненности цереброваскулярной патологии, а также ней-родегенеративных болезней. По данным ВОЗ, деменция занимает 3-е место среди причин смертности населения земного шара после заболеваний сердца и злокачествен-ных новообразований. К апрелю 2012 г. в мире насчиты-валось 35,6 млн больных деменцией. К 2030 г. предпола-гается увеличение числа таких пациентов почти в 2 раза (до 56,7 млн)

show abstract

Two-year outcome of MCI subtypes and aetiologies in the Goteborg MCI study

Cited by 107 publications

References 43 publications

MEG spectral analysis in subtypes of mild cognitive impairment

MEG spectral analysis in subtypes of mild cognitive impairment

Reversion from mild cognitive impairment to normal or near-normal cognition

Value of determining the cerebrospinal fluid protein markers of amyloidosis and neurodegeneration in the diagnosis of vascular and neurodegenerative cognitive impairments

Contact Info

Product

Resources

About