Two Yearʼs Experience With Periodic Hemodialysis in the Treatment of Chronic Uremia

Long, Slow Dialysis

“…Other groups using vincing: In the US, the delivered Kt/V dose decrease in 1986-89 was followed by a rising mortality. Conversely 8-h dialysis in the past [22] and more recently [3,9,23] also regularly achieved and still achieve longstanding nordelivered Kt/V urea has increased since 1990, this has been followed by a decrease in mortality. Furthermore, motension.…”

Effect of chronic renal failure and hemodialysis on carbohydrate metabolism.

“…With the advent of periodic hemodialysis, patients with chronic renal failure can be maintained in relatively good health over long periods of time (7), and the clinical syndrome of uremia can be evaluated under controlled conditions. If the abnormality of carbohydrate metabolism is truly a result of renal failure and not solely associated with nonspecific factors such as starvation, stress, or latent diabetes mellitus, an experiment controlling such variables might shed light on the metabolic defect or defects involved.…”

Relationship of nervous tissue transketolase to the neuropathy in chronic uremia

“…Two examples of detailed electrophysiologic evaluations which paralleled the testing of TKA inhibition gave the following results: M.K., a typical case of those di- Dialyzability of the inhibitor (s) is clearly demonstrated when plasma from patients on hemodialysis loses its TKA suppressing properties and inhibitory substance(s) of low molecular weight can be recovered in the dialysates. Elimination of neurotoxic factors by dialysis has been suggested by the observations of several dialysis centers as well as by our own experience that the neurologic deficits of uremic patients are amenable to vigorous dialysis (1)(2)(3)(37)(38)(39). The finding that the uremic patients' neuropathy and TKA inhibition values of their plasma show a reasonable correlation and a similar response to effective long-term dialytic treatment could reflect a causal relation of these two expressions of the uremic state.…”