Two years survival of primary cardiac leiomyosarcoma managed by surgical and adjuvant therapy

Behi, Khalil; Ayadi, Mouna; Mezni, Essia; Meddeb, K.; Mokrani, Amina; Yahyaoui, Yosra; Ksontini, Feryel Letaief; Raïs, H.; Chrait, Nesrine; Mézlini, Amel

doi:10.1186/s13569-017-0069-3

Cited by 10 publications

(12 citation statements)

References 31 publications

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Section: Treatment Of Cardiac Sarcomasmentioning

confidence: 99%

“…In the literature, the optimal treatment approach regarding postoperative adjuvant therapy remains unclear: some studies found that the adjuvant approach failed to modify the natural course of the disease, 7,8 while others have demonstrated a better survival for patients whose surgery was followed by adjuvant chemotherapy. 6,9 Overall, anthracyclines (in particular, doxorubicin) and nitrogen mustard alkylating agents (in particular, ifosfamide), which represent the preferred chemotherapeutic choice to treat sarcomas originating from other sites, are the most common chemotherapy agents used also for cardiac sarcomas. However, the typical cardiotoxicity of anthracyclines should be kept in mind when adjuvant treatment is proposed to a patient.…”

Section: Treatment Of Cardiac Sarcomasmentioning

confidence: 99%

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¹⁸F-FDG-PET/CT imaging in cardiac tumors: illustrative clinical cases and review of the literature

et al. 2018

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Cardiac tumors are a very rare condition. Mostly, they are benign tumors (75%), with myxomas being the most frequent. The remaining 25% are malignant; either primary malignant sarcoma or secondary metastases. Given the small number of cases reported and the lack of prospective and randomized clinical trials, the level of evidence for the optimal multimodal treatment of primary cardiac sarcomas is very low and the optimal imaging diagnostic workup is not well established. In particular, 18F-FDG-PET/CT is not yet included in routine diagnosis of cardiac masses. Here, we report four illustrative clinical cases and a review of the literature on the current available data on the role of 18F-fluorodeoxyglucose PET/CT imaging in cardiac tumors.

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Section: Treatment Of Cardiac Sarcomasmentioning

confidence: 99%

Section: Treatment Of Cardiac Sarcomasmentioning

confidence: 99%

¹⁸F-FDG-PET/CT imaging in cardiac tumors: illustrative clinical cases and review of the literature

et al. 2018

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“…Other treatment regimens include combination of docetaxel and gemcitabine, and cyclophosphamide, vincristine, doxorubicin and dacarbazine 23. A very recent case of left atrial leiomyosarcoma in a 51-year-old patient was reported, who was also treated with surgery and six cycles of doxorubicin and ifosfamide and was found free of any recurrence after 2 years 25. We also gave six cycles of doxorubicin and ifosfamide in adjuvant setting to our patient.…”

Section: Discussionmentioning

confidence: 83%

Primary cardiac leiomyosarcoma presenting as haemoptysis in a 22-year-old patient: an unusual presentation of a rare condition

Hassan¹,

Khattak²,

Abdullah³

et al. 2017

BMJ Case Reports

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Primary cardiac sarcomas are rare malignant tumours and among them, leiomyosarcoma is extremely rare. They are especially rare in a young age group. We present a case of a 22-year-old male patient with primary leiomyosarcoma of the left atrium involving the pulmonary veins who presented with haemoptysis and shortness of breath. He underwent surgical excision of the tumour along with mitral valve replacement followed by adjuvant chemotherapy. No recurrence was reported on his second 6 monthly follow-ups.

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“…The unobstructed view from transesophageal echocardiography allows excellent visualization of structures not well seen on TTE, with a higher resolution [13]. CT scan and cardiac MRI may also provide further information about morphology, location, and extent of the mass [16].…”

Section: Discussionmentioning

confidence: 99%

Primary Leiomyosarcoma of the Left Atrium

Saldanha

Shetty²,

Nirmala³

2019

Journal of Case Reports: Open Access

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Objectives: To present a case of a leiomyosarcoma of the left atrium, presenting as exertional dyspnea in a middle-aged Filipino. This study likewise presents a review of current literature.Results: A 44 years old female presented with a three-day history of exertional dyspnea. Transesophageal echocardiography revealed a mass with pericardial effusion and a large mass occupying almost the entire left atrial cavity. She underwent complete excision with mitral valve repair. Histopathology revealed bundles of fascicles of spindle-shaped cells with eosinophilic infiltrates, positive for SMA, Caldesmon, and Vimentin, and a high Ki67 of >50% --consistent with primary leiomyosarcoma. No adjuvant chemotherapy was done. Within three months of post-operation and lost to follow-up, the patient noted the recurrence of dyspnea. Echocardiography revealed the recurrence of the mass, again obstructing the left atrium.Metastatic lesions were also on both lungs. The patient was planned a 2nd resection of the mass, followed by systemic chemotherapy, but died due to obstructive heart failure.Summary/conclusion: Primary cardiac leiomyosarcomas (PCLMS) are extremely rare tumors. Studies reveal female preponderance with mean age of 48 years. The tumors seem to originate from the cardiac chambers, without the involvement of the pericardium and great vessels. Increased tumor burden, metastatic disease, high proliferative index, and high-grade tumors usually translate to a worse prognosis. Complete surgical resection of the tumor is still the mainstay of treatment followed by doxorubicin, ifosfamide, or dacarbazine-based regimens.

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Two years survival of primary cardiac leiomyosarcoma managed by surgical and adjuvant therapy

Cited by 10 publications

References 31 publications

¹⁸F-FDG-PET/CT imaging in cardiac tumors: illustrative clinical cases and review of the literature

¹⁸F-FDG-PET/CT imaging in cardiac tumors: illustrative clinical cases and review of the literature

Primary cardiac leiomyosarcoma presenting as haemoptysis in a 22-year-old patient: an unusual presentation of a rare condition

Primary Leiomyosarcoma of the Left Atrium

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Two years survival of primary cardiac leiomyosarcoma managed by surgical and adjuvant therapy

Cited by 10 publications

References 31 publications

18F-FDG-PET/CT imaging in cardiac tumors: illustrative clinical cases and review of the literature

18F-FDG-PET/CT imaging in cardiac tumors: illustrative clinical cases and review of the literature

Primary cardiac leiomyosarcoma presenting as haemoptysis in a 22-year-old patient: an unusual presentation of a rare condition

Primary Leiomyosarcoma of the Left Atrium

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Product

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¹⁸F-FDG-PET/CT imaging in cardiac tumors: illustrative clinical cases and review of the literature

¹⁸F-FDG-PET/CT imaging in cardiac tumors: illustrative clinical cases and review of the literature