TXNDC9 regulates oxidative stress-induced androgen receptor signaling to promote prostate cancer progression

Feng, Tingting; Zhao, Ru; Sun, Feifei; Lu, Qingming; Wang, Xueli; Hu, Jing; Wang, Shiguan; Gao, Lin; Zhou, Qianqian; Xiong, Xueting; Dong, Xuesen; Wang, Lin; Han, Bo

doi:10.1038/s41388-019-0991-3

Cited by 30 publications

(29 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The encoded protein is a key regulator of signaling by androgens, a class of steroid hormones involved in male reproductive development. Feng et al [47] noted that ROS activate Ar functions by the TXNDC9-PRDX1 axis in prostate cancer (PCa) cells. In the present study, we observed the highest correlation between lncRNA NONMMUT 010961.2 and Ar (Supplementary Figure 1B and Table 2).…”

Section: Discussionmentioning

confidence: 99%

RNA-seq analysis of potential lncRNAs for age-related hearing loss in a mouse model

Zhao

Liu

Sun

et al. 2020

Aging

View full text Add to dashboard Cite

Age-related hearing loss (AHL) is an important health problem in the elderly population. Its molecular mechanisms have not been fully elucidated. In this study, we analyzed the differential expression of lncRNAs and mRNAs in the cochleae of six-week-old and one-year-old C57BL/6J mice through RNA-seq analysis. We found 738 and 2033 differentially expressed lncRNAs and mRNAs, respectively, in these two groups (corrected P < 0.05). We focused on the intersection of known genes associated with hearing loss and differentially expressed mRNAs in RNA-seq. There are 34 mRNAs in this intersection, which include all 29 mRNAs enriched in the sensory perception of sound (GO: 0007605). We selected 11 lncRNAs that are predicted to regulate the 34 mRNAs to validate their expression levels in animal and cellular models of AHL by qRT-PCR. Among these lncRNAs, four were significantly different in both animal and cellular models of AHL, and the lncRNA NONMMUT010961.2 was the most markedly different. Knocking down lncRNA NONMMUT010961.2, we found the expression of oxidative stress and apoptosis-related gene Ar and hearing loss-related gene Hgf is significantly reduced in HEI-OC1 cells. Our results suggest that lncRNAs NONMMUT010961.2 may be associated with AHL and may thus lead to a new treatment for AHL.

show abstract

Section: Discussionmentioning

confidence: 99%

RNA-seq analysis of potential lncRNAs for age-related hearing loss in a mouse model

Zhao

Liu

Sun

et al. 2020

Aging

View full text Add to dashboard Cite

show abstract

“…Tumors have increased TXNDC9, and it correlates with advanced clinical stages. [170] TXNIP expression is decreased in prostate cancer. [160] Thyroid cancer TRXR1 expression is decreased in thyroid cancer cells compared to healthy cells.…”

Section: Tumor Type Involvement Of Trx Systemmentioning

confidence: 98%

“…Among the TXNDC protein family, TXNDC5 has been studied the most and was found to be overexpressed in tumor tissues [165][166][167], and its high expression correlates with poor survival [168]. Other TXNDCs reported to be altered in tumors are TXNDC9 [169,170] and TXNDC17 [171]. Oxidized TRX is reduced to the active reduced form of TRX by TRXR that uses NADPH as the main electron source.…”

Section: The Thioredoxin System and Thioredoxin-domain-containing Promentioning

confidence: 99%

The NRF2, Thioredoxin, and Glutathione System in Tumorigenesis and Anticancer Therapies

et al. 2020

View full text Add to dashboard Cite

Cancer remains an elusive, highly complex disease and a global burden. Constant change by acquired mutations and metabolic reprogramming contribute to the high inter- and intratumor heterogeneity of malignant cells, their selective growth advantage, and their resistance to anticancer therapies. In the modern era of integrative biomedicine, realizing that a personalized approach could benefit therapy treatments and patients’ prognosis, we should focus on cancer-driving advantageous modifications. Namely, reactive oxygen species (ROS), known to act as regulators of cellular metabolism and growth, exhibit both negative and positive activities, as do antioxidants with potential anticancer effects. Such complexity of oxidative homeostasis is sometimes overseen in the case of studies evaluating the effects of potential anticancer antioxidants. While cancer cells often produce more ROS due to their increased growth-favoring demands, numerous conventional anticancer therapies exploit this feature to ensure selective cancer cell death triggered by excessive ROS levels, also causing serious side effects. The activation of the cellular NRF2 (nuclear factor erythroid 2 like 2) pathway and induction of cytoprotective genes accompanies an increase in ROS levels. A plethora of specific targets, including those involved in thioredoxin (TRX) and glutathione (GSH) systems, are activated by NRF2. In this paper, we briefly review preclinical research findings on the interrelated roles of the NRF2 pathway and TRX and GSH systems, with focus given to clinical findings and their relevance in carcinogenesis and anticancer treatments.

show abstract

“…Four—It specifically targets extracellular EGF repeats of important proteins such as NOTCH1 and NOTCH3 ( Takeuchi et al, 2018 ), indicating its possible roles in the Notch signaling pathway. Five—Using STRING database, we found that it had interactions with several proteins involved in different cancers such as TXNDC9 ( Feng et al, 2020b ), GXYLT2 ( Cui et al, 2019 ), POFUT1 ( Chabanais et al, 2018 ) , XXYLT1( Zeng et al, 2021 ) , FLNA ( Guo et al, 2018 ), and ZC3H12C ( Suk et al, 2018 ) ( Figure 4 ). These evidences strengthen the possible important role of KDELC1 in various malignancies .…”

Section: Resultsmentioning

confidence: 99%

LncRNA–miRNA–mRNA Networks of Gastrointestinal Cancers Representing Common and Specific LncRNAs and mRNAs

et al. 2022

View full text Add to dashboard Cite

Gastrointestinal (GI) cancers are responsible for approximately half of cancer-related deaths, highlighting the need for the identification of distinct and common features in their clinicopathological characteristics. Long ncRNA (lncRNAs), which are involved in competitive endogenous RNA (ceRNA) networks with critical roles in biological processes, constitute a substantial number of non-coding RNAs. Therefore, our study aimed to investigate the similarities and differences in the ceRNA networks of The Cancer Genome Atlas (TCGA)-GI cancers. We performed a comprehensive bioinformatics analysis of ceRNA networks for TCGA-GI cancers in terms of the deferential mRNA, lncRNA, and miRNA expression levels, ceRNA networks, overall survival analysis, correlation analysis, pathological cancer stages, and gene set enrichment analysis. Our study revealed several common and distinct mRNAs and lncRNAs with prognostic values in these networks. It was specifically noteworthy that MAGI2-AS3 lncRNA was found to be shared in almost all GI cancers. Moreover, the most common shared mRNAs between GI cancers were MEIS1, PPP1R3C, ADAMTSL3, RIPOR2, and MYLK. For each cancer ceRNA network, we found that the expression level of a number of lncRNAs and mRNAs was specific. Furthermore, our study provided compelling evidence that several genes, most notably KDELC1, can act as novel proto-oncogenes in cancers. This, in turn, can highlight their role as new prognostic and therapeutic targets. Moreover, we found cell cycle and extracellular matrix structural constituent as the top shared KEGG and molecular function, respectively, among GI cancers. Our study revealed several known lncRNAs and known and unknown mRNAs in GI cancers with diagnostic and prognostic values.

show abstract

TXNDC9 regulates oxidative stress-induced androgen receptor signaling to promote prostate cancer progression

Cited by 30 publications

References 41 publications

RNA-seq analysis of potential lncRNAs for age-related hearing loss in a mouse model

RNA-seq analysis of potential lncRNAs for age-related hearing loss in a mouse model

The NRF2, Thioredoxin, and Glutathione System in Tumorigenesis and Anticancer Therapies

LncRNA–miRNA–mRNA Networks of Gastrointestinal Cancers Representing Common and Specific LncRNAs and mRNAs

Contact Info

Product

Resources

About