TXNIP/NLRP3 aggravates global cerebral ischemia-reperfusion injury-induced cognitive decline in mice

Yang, Chengjie; Mo, Jing; Liu, Qingmei; Li, Wei; Chen, Ye; Feng, Jianguo; Jia, Jing; Liu, Li; Bai, Yiping; Zhou, Jun

doi:10.1016/j.heliyon.2024.e27423

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e27423

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TXNIP/NLRP3 aggravates global cerebral ischemia-reperfusion injury-induced cognitive decline in mice

Chengjie Yang,

Jing Mo,

Qingmei Liu

et al.

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2024

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Cited by 2 publications

References 56 publications

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TXNIP knockdown protects rats against bupivacaine-induced spinal neurotoxicity via the inhibition of oxidative stress and apoptosis

Zhao,

Chen,

Liu

et al. 2024

Free Radical Biology and Medicine

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TXNIP knockdown protects rats against bupivacaine-induced spinal neurotoxicity via the inhibition of oxidative stress and apoptosis

Zhao,

Chen,

Liu

et al. 2024

Free Radical Biology and Medicine

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The impact of neuroinflammation on neuronal integrity

Tastan,

Heneka

2024

Immunological Reviews

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SummaryNeuroinflammation, characterized by a complex interplay among innate and adaptive immune responses within the central nervous system (CNS), is crucial in responding to infections, injuries, and disease pathologies. However, the dysregulation of the neuroinflammatory response could significantly affect neurons in terms of function and structure, leading to profound health implications. Although tremendous progress has been made in understanding the relationship between neuroinflammatory processes and alterations in neuronal integrity, the specific implications concerning both structure and function have not been extensively covered, with the exception of perspectives on glial activation and neurodegeneration. Thus, this review aims to provide a comprehensive overview of the multifaceted interactions among neurons and key inflammatory players, exploring mechanisms through which inflammation influences neuronal functionality and structural integrity in the CNS. Further, it will discuss how these inflammatory mechanisms lead to impairment in neuronal functions and architecture and highlight the consequences caused by dysregulated neuronal functions, such as cognitive dysfunction and mood disorders. By integrating insights from recent research findings, this review will enhance our understanding of the neuroinflammatory landscape and set the stage for future interventions that could transform current approaches to preserve neuronal integrity and function in CNS‐related inflammatory conditions.

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TXNIP/NLRP3 aggravates global cerebral ischemia-reperfusion injury-induced cognitive decline in mice

Cited by 2 publications

References 56 publications

TXNIP knockdown protects rats against bupivacaine-induced spinal neurotoxicity via the inhibition of oxidative stress and apoptosis

TXNIP knockdown protects rats against bupivacaine-induced spinal neurotoxicity via the inhibition of oxidative stress and apoptosis

The impact of neuroinflammation on neuronal integrity

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