Tye hypoglycaemic effect of Azadirachta Inica in rat

Aderibigbe, AO; Emudianughe, T. S.; Lawal, Bas; Oluwagbemi, JB

doi:10.4314/nqjhm.v9i4.12412

Cited by 7 publications

(7 citation statements)

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“…TELFAIRIA OCCIDENTALIS (UGU): It is a tropical vine grown in West Africa as a leaf vegetable and for its edible seeds [59]. Also known as fluted pumpkin.It is a leafy green vegetable that is popular in Nigerian cuisine and other parts of West Africa.…”

Section: ©Nijses Publicationsmentioning

confidence: 99%

Medicinal Plants Alternative to Pharmacological Agents Used in the Treatment of Anaemia

Buhari,

Ismail,

Obeagu

2023

NIJSES

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Medicinal plants have long been recognized for their therapeutic potential and serve as valuable alternatives to pharmacological agents in managing various health conditions, including anaemia. This paperaims to elucidate the diverse array of medicinal plants employed in the treatment of anemia. The exploration encompasses a comprehensive analysis of plant-based remedies across different cultures and traditions, highlighting their bioactive compounds, mechanisms of action, and efficacy in ameliorating anemia. Additionally, emphasis is placed on the utilization of these botanical sources as natural supplements or adjuncts to conventional therapies, focusing on their safety profiles and potential adverse effects. Furthermore, the paper evaluates the scientific evidence supporting the efficacy of these medicinal plants through in vitro, in vivo, and clinical studies, while also discussing the challenges associated with standardization and quality control. By synthesizing this knowledge, the review underscores the importance of integrating traditional herbal medicine into evidence-based healthcare practices, fostering a holistic approach for managing anemia and paving the way for future research and therapeutic advancements in this domain. Keywords: medicinal plants; pharmacological agents; treatment; anaemia

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Section: ©Nijses Publicationsmentioning

confidence: 99%

Medicinal Plants Alternative to Pharmacological Agents Used in the Treatment of Anaemia

Buhari,

Ismail,

Obeagu

2023

NIJSES

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“…Similarly, Alada [10] and Ajayi [18] reported increased haematological parameters from aqueous leaf extract of T. occidentalis in laboratory animals. Aderibigbe et al [19], Nwajo et al [20], and Eseyin et al [21] reported that extract of T. occidentalis was observed to reduce blood glucose level in glucose induced hyperglycaemic, and to also have anti-diabetic effects in streptozotocin and alloxan induced diabetic laboratory animals. Oboh [22] reported that the aqueous extract of T. occidentalis has hepatoprotective effect against garlic-induced oxidative stress.…”

Section: Reviewmentioning

confidence: 99%

Evaluation of Anticonvulsant Activity of Aqueous Leaf Extract of Telfairia occidentalis in Mice

Imoru

Ajayi

Rufus

2015

EJMP

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“…In addition, previous work also reported that dietary intake of T. occidentalis leaves could prevent garlic-induced hemolytic anemia in rats (Oboh and Akindahunsi, 2004). Also, studies showed that the aqueous extracts of T. occidentalis can reduce blood glucose levels and have antidiabetic effects in glucoseinduced hyperglycaemic streptozotocin (STZ) in mice (Aderibigbe et al, 1999). Furthermore, the leaf extracts of T. occidentalis is used to manage cholesterolemia, liver problems, and inflammatory conditions (Eseyin et al, 2010).…”

Section: Introductionmentioning

confidence: 98%

Effect of extraction temperature on the phytochemicals, minerals and antioxidant properties of<em> Telfairia occidentalis</em> leaf extracts

Awoniyi,

Ogunmola,

Babatunde

et al. 2023

Ceylon J. Sci.

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Telfairia occidentalis leaves are known to possess many therapeutic potentials such as antidiabetic, anti-inflammatory, anticholesterolemic etc. To maximize their use in phytomedicine, the conditions used in preparation methods are crucial. Therefore, this study estimated the effect of extraction temperature on the phytochemicals, minerals, and antioxidant properties of T. occidentalis leaves. The powdered samples of T. occidentalis leaves were extracted using water at 1000C and 250C, respectively, followed by the phytochemical, mineral and antioxidant analyses of the plant extracts. The concentration of most constituent metabolites in the cold extract of T. occidentalis leaves was significantly (p < 0.05) higher than that of the hot extract. The highest mineral concentrations in hot and cold extracts of T. occidentalis leaves were sodium (2.22 mg/L) and potassium (2.77 mg/L), respectively. In the antioxidant study, the EC50 values (131.20 ± 1.70 μg/ml and 105.08 ± 0.54 μg/ml) of the hot extract of T. occidentalis leaves were significantly (p < 0.05) lower than those of the cold extract (228.17 ± 23.03 μg/ml and 151.47 ± 14.68 μg/ml). The study reveals that the extracts hold varying biological importance. The cold aqueous extract can be an excellent nutritional adjuvant for the supply of essential nutrients, whereas the hot aqueous extract can act as an important agent in ameliorating pathological conditions thrive on excessive free radical generation. Therefore, the different extraction procedures can be utilized based on the desired biological outcome.

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Tye hypoglycaemic effect of Azadirachta Inica in rat

Cited by 7 publications

References 0 publications

Medicinal Plants Alternative to Pharmacological Agents Used in the Treatment of Anaemia

Medicinal Plants Alternative to Pharmacological Agents Used in the Treatment of Anaemia

Evaluation of Anticonvulsant Activity of Aqueous Leaf Extract of Telfairia occidentalis in Mice

Effect of extraction temperature on the phytochemicals, minerals and antioxidant properties of<em> Telfairia occidentalis</em> leaf extracts

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