Tylosis and Intrathoracic Neoplasms

Schwindt, Walter D.; Bernhardt, Louis C.; Johnson, Sture A. M.

doi:10.1378/chest.57.6.590

Cited by 16 publications

(2 citation statements)

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“…Parnell & Johnson (1969) reported two cases with metastatic carcinoma, one of bronchus and the other of oesophagus, with late onset tylosis, and found a further three cases with carcinoma of the oesophagus of acquired type and tylosis in a review of case notes. Schwindt, Bernhardt & Johnson (1970) recorded two cases with late onset hyperkeratosis of the palms and soles, one associated with carcinoma of the oesophagus, and one with metastatic squamous carcinoma. Riddick, Brodkin & Gibbs (1971) reported a further case associated with carcinoma of the lung, and Millard & Gould (1976) three cases associated respectively with carcinoma of the bronchus, stomach and breast.…”

Section: Discussionmentioning

confidence: 99%

Acanthosis palmaris: tripe palms. a distinctive pattern of palmar keratoderma frequently associated with internal malignancy

Breathnach

Wells

1980

Clin Exp Dermatol

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Summary We describe five patients who showed a distinctive pattern of late onset hyperkeratosis and acanthosis of palms and fingers. The epidermal thickening gave rise to a rugose appearance with broadened rete ridges bounded by deep sulci (tripe palms). One of these patients had malignant acanthosis nigricans, two also had carcinomata with the palmar changes as a forme fruste of acanthosis nigricans and two patients had pruriginous dcrmatoses with palmar changes of diffuse lichenification which were reversible. The relationship between palmar‐plantar keratoderma and malignancy is discussed.

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Section: Discussionmentioning

confidence: 99%

Acanthosis palmaris: tripe palms. a distinctive pattern of palmar keratoderma frequently associated with internal malignancy

Breathnach

Wells

1980

Clin Exp Dermatol

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“…Davon abgrenzen muß man solche Fallbeschreibungen, bei denen sich tylotische Hautveränderungen erstmals im Zusammenhang mit einem Malignom oder einer Ösophagusstriktur manifestieren [12,18,24,25,29,30,32,33] und die eher den Charakter eines paraneoplastischen Phänomens haben.…”

Section: Stammbaum Der Familie Und Ergebnisse Der Klinischen Nachunteunclassified

Das Clarke-Howel-Evans-McConnell-Syndrom

Simón

Hagedorn

1997

Der Hautarzt

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The Clarke-Howel-Evans-McConnell syndrome is a rare hereditary disease characterized by palmoplantar keratoses, squamous cell carcinoma of the esophagus and oral leukoplakia. According to a new classification recently proposed by Stevens and colleagues, the syndrome can also be classified as palmoplantar ectodermal dysplasia type III. We report a family from the Black Forest region of Germany afflicted with the syndrome. The family was traced through five generation. 27 of 46 family members showed tylotic skin changes. In addition, 8 patients showed oral leukoplakia and 5 died from squamous cell carcinoma of the esophagus. Using screening examinations, early changes of the esophageal mucosa could be detected. The responsible gene has been mapped in the family. It is located at 17q23-qter, telomeric to the keratin II gene cluster. Therefore a defect in one of the well known keratin genes can be excluded as a cause of the syndrome.

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