Tympanometry measures in native and non-native Hawaiian children

Pugh, Kenneth C.; Burke, Henry W.K; Brown, Heidi M

doi:10.1016/j.ijporl.2004.01.002

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…genetic variability among the 45 normal mouse strains, the average standard deviation of 0.13 ml for compliance values from both ears is within the expected range. Our data are consistent with other reports in human children (Pugh et al, 2004), taking into account that human equivalent ear-canal volume is much greater than that of mice. Pugh and colleagues reported compliance, gradient and pressure variables from 182 native Hawaiian and 177 non-native Hawaiian children.…”

Section: Appropriateness and Precision Of Tympanometry For Assessing supporting

confidence: 93%

Tympanometry assessment of 61 inbred strains of mice

et al. 2007

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Otitis media (OM) accounts for more than 20 million clinic visits in the United States every year. Resistance to antibiotics has hampered current management of the disease. Identification of genetic factors underlying susceptibility to OM is greatly needed in order to develop alternative treatment strategies. Genetically defined inbred mouse strains offer a powerful tool for dissecting genetic and environmental factors that may lead to OM in mice. Here, we report a study of middle ear function of 61 genetically diverse inbred strains of mice using tympanometry. Of the 61 inbred strains tested, the 129P1/ReJ, 129P3/J, 129S1/SvImJ, 129X1/SvJ, A/HeJ, BALB/cJ, BUB/BnJ, C57L/J, EL/SuzSeyFrkJ, FVB/NJ, I/LnJ, LP/J, NZB/BlNJ, PL/J and YBR/Ei strains exhibited tympanograms that were statistically different from other healthy strains according to parameters including middle ear pressure, volume and compliance. These differences are most likely the result of genetic factors that, when understood, will facilitate prevention and treatment of otitis media in humans. In addition, a negative correlation between age and compliance of the tympanic membrane was discovered. This is the first report to successfully use tympanometry to measure mouse middle ear function, which has been a challenge for the hearing research field because of the mouse's tiny ear size.

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Section: Appropriateness and Precision Of Tympanometry For Assessing supporting

confidence: 93%

Tympanometry assessment of 61 inbred strains of mice

et al. 2007

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“…Tympanometry provides a quick examination of the middle ear. The standard deviations for compliance in our control rats (0.13 -0.17) are consistent with those reported for humans (0.097 -0.107 ml) [22] [23] taking into consideration that human equivalent ear canal volume is much bigger than that of rats.…”

Section: Use Of Tympanometrysupporting

confidence: 90%

Tympanometry Comparison of Diabetic Type I and Diabetic Type II Rats

Amin¹,

Alaradi²,

Alekri³

et al. 2023

JDM

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Hearing impairment affects over two-thirds of adults with diabetes. We investigated whether rat models of type 1 and type 11 diabetes display impaired auditory function. Tympanometry measurements were conducted in Sprague-Dawley rats (control, n = 20), streptozotocin-induced type I diabetic Sprague-Dawley rats (n = 20) at 42 -56 days old; Zucker rats (Hos: ZFDM-Lean (fa/+, n = 20) and Zucker Type 2 Diabetic rats (ZFDM (Hos: ZFDMfa/fa); n = 20)), 90 days old. All rats were male. Control animals had normal type A tympanograms. Tweny one (75%) of the tympanic membranes in the diabetic type I group produced abnormal tympanograms: 46% were type B, 28% had no peak found, and 1% were type C. The ear canal measurements were lower in the left ear in type I mice (0.19 ± 0.07) and higher in the left ear for type II mice (0.23 ± 0.15 ml) compared to the controls of 0.39 ± 0.14 ml) and (0.2 ± 0.12 ml) respectively (P < 0.0001). The compliances for the right ear and left ear were lower for the type II diabetic group (0.18 ± 0.05 ml) and (0.18 ± 0.05 ml) compared to the control group (0.28 ± 0.19 ml) and (0.28 ± 0.49 ml) (P < 0.0001) respectively. In conclusion, control rats exhibited type A tympanograms with a highly functional middle ear system. Diabetic type I rats (n = 20) mostly exhibited type B tympanograms with a less compliant middle ear system. Compliance was reduced in the diabetic type I and II animals compared to the control. Future studies should utilise histological methods alongside tympanometry. Sections of the middle ear could be used to analyze ossicle size and confirm size differences. This information would be useful in avenues for treatment options for hearing loss in diabetes.

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“…In reviewing the literature, several studies support race or ethnicity as a predisposing factor for middle ear pathology [5][6][7][8][9][10][11][12][13][14]. However, only one study has compared rates of middle ear disease in Asian and White children.…”

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confidence: 99%