Tympanosclerosis of the drum in secretory otitis after insertion of grommets

Tos, Mirko; Bonding, Per; Poulsen, G.

doi:10.1017/s0022215100094445

Cited by 73 publications

(39 citation statements)

References 25 publications

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“…From the results obtained in this study, it was not possible to establish any statistically significant association among gender and the development of myringosclerosis, as occurred with Kaur et al [17] and Tos et al [20]. In this study, it was not possible to find an association between elevated calcemia levels and the development of myringosclerosis, as described by Leal et al [13], who pointed this as one of the factors responsible for the development of myringosclerosis.…”

Section: Discussionmentioning

confidence: 47%

Predictive factors for the appearance of myringosclerosis after myringotomy with ventilation tube placement: randomized study

Branco

Monteiro

Paço

2016

Eur Arch Otorhinolaryngol

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Myringotomy with the insertion of ventilation tubes is the most frequent surgical procedure performed in children, and the appearance of myringosclerosis is one of its most frequent long-term complications. The objective of this study is to identify clinical factors and technique variations that may have a relation with the appearance of myringosclerosis, after tube insertion. Patients submitted to myringotomy with transtympanic short-term tube insertion were studied in a longitudinal prospective and analytical cohort study with the prospective randomized open, blinded endpoint (PROBE) methodology, to study the influence of the location of myringotomy (anterior-inferior quadrant or posterior-inferior), directions of the incision (radial or nonradial) and aspiration or not of the middle ear. Our study included 156 patients (297 ears). Myringosclerosis was observed in 35.7 % of the operated ears. It appeared more often in patients with greater number of otitis (p = .001) and with greater number of otorrhea episodes (p = .029) and in patients in whom the tympanogram after the tube extraction was type A (according to Jergeŕs classification) (p = 0.016). We identified myringosclerosis in less patients, if the tube was in the tympanic membrane for less than 12 months (p = .009). Myringosclerosis was present more extensively if the tympanic incision was located in the anterior-inferior quadrant, with tympanic involvement superior to 25 % (p = .015). The results observed prove that, underlying the appearance of myringosclerosis, there exists an early inflammatory or infectious process and a final cicatricial process. It was also found that when myringotomy is made in the anterior-inferior quadrant, myringosclerosis appears in a higher percentage of the tympanic membrane; therefore, it is not recommended to do the incision in this quadrant, because it may lead to a reduction of the tympanic membrane vibration.

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Section: Discussionmentioning

confidence: 47%

Predictive factors for the appearance of myringosclerosis after myringotomy with ventilation tube placement: randomized study

Branco

Monteiro

Paço

2016

Eur Arch Otorhinolaryngol

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“…Mc Rae bu oranın % 25 ile % 70 arasında değiştiğini bildirmiştir (5). Tos ise % 25-30 oranını vermiş-tir (9). Bizim serimizde 39/62 (% 62.9) oranında miringoskleroz gö-rülmüştür.…”

Section: Materyal Ve Metodunclassified

Ti̇mpanoskleroz Etyoloji̇si̇nde Allerji̇ni̇n Yeri̇

Gökhan;IŞIK¹

1994

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Timpanosklerozda patoloji; kulak zarında, veya orta kulakta submukozal konnektif dokuda oluşan ve kalsifiye olabilen hyalen dejeneresansdır (7,11). Spesifik bir hastalık olmayıp, çeşitli etkenler sonucunda oluşabilen bir hatalı iyileşme proçesidir. Akut ve kronik orta kulak inflamasyonlarını ve travmaları takiben görülebilmektedir. Ancak aynı etkenin bütün hastalarda timpanoskleroza yol açmaması, etyopatogenezinde hastaya ilişkin faktörlerin sorumlu olduğunu dü-şündürmektedir. En çok suçlanan faktörler allerji ve otoimmünitedir (3,7).Timpanoskleroz gelişiminde allerjik mekanizmaların rolü hastalardan alman allerji anamnezi ve mukoza biopsileri ile gösterilmeye çalışılmıştır. Bizim çalışmamızda ise Effüzyonlu Otitis Media (EOM) tanısıyla ventilasyon tüpü uygulanan çocuklarda, miringoskleroz gelişmesiyle serum IgE, nazal smearde eozinofil ve kanda total eozinofil düzeyleri arasındaki ilişki araştırılmıştır. MATERYAL VE METODAÜTF -KBB Kliniğinde 1990 -1991 yılları arasında EOM teşhisiy-le öpere edilerek ventilasyon tüpü uygulanan hastalardan 62 si incelendi. Bütün hastalara Sheppard -Grommet ventilasyon tüpü kullanıl-dı. Hastalar tüpün alınmasını takiben üçüncü ayda yapılan kontrol muayenelerine göre miringoskleroz görülen ve görülmeyen olmak üze-re iki gruba ayrıldı. Her iki grup yaş, cinsiyet, ventilasyon tüpünün kalma süresi, serum IgE, nazal smearde eozinofil ve kan da total eozinofil seviyeleri açısından değerlendirilerek birbiriyle karşılaştırıldı.

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“…Even though TS is usually asymptomatic, it can cause hearing loss when it has a wide area of involvement and when it limits ossicle movement [2] . The involvement of TS in the tympanic membrane and the emergence of a whitish chalky patch are conditions often seen clinically, and such conditions are called myringosclerosis (MS).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Alpha-Lipoic Acid on Myringosclerosis in a Rat Model

Tatar¹,

Yörük²,

Ünal³

et al. 2015

Int Adv Otol

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OBJECTIVE: Alpha-lipoic acid (ALA) is an anti-inflammatory and antioxidant agent. In this study, the effects of ALA on the development of myringosclerosis in myringotomized rats were investigated. MATERIALS and METHODS:The rats were studied in five groups: each group included 6 rats (for a total of 30 rats). After a myringotomy was performed, the groups were administered a 25-mg/kg/day and 50-mg/kg/day dose of ALA for 15 days. The eardrums of the rats were examined histopathologically. We made the histopathological assessment from 0 to 3 on a 4-point scale by scoring the degree of the histopathological changes. In addition, superoxide dismutase, malondialdehyde, and glutathione peroxidase levels were measured in blood samples taken from the rats. RESULTS:In histopathological examinations, a high dose (50 mg/kg/day) of the ALA-applied group had histopathological results similar to those of the healthy group. In this group, we detected minimal collagen deposition, slight thickness in the lamina propria, and minimal epithelial disruption. In biochemical examinations, the maximum values of superoxide dismutase and glutathione peroxidase were observed in the group that received 50 mg/kg/day of ALA. CONCLUSION:In this study, the effect of ALA on myringosclerosis development was observed when a dose of 50 mg/kg/day was administered, and a recovery that showed a nearly intact tympanic membrane occurred at the end of 15 days of use. If an antioxidant were to be added to the treatment protocol of tympanic membrane defects, ALA may be a good candidate.

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Tympanosclerosis of the drum in secretory otitis after insertion of grommets

Cited by 73 publications

References 25 publications

Predictive factors for the appearance of myringosclerosis after myringotomy with ventilation tube placement: randomized study

Predictive factors for the appearance of myringosclerosis after myringotomy with ventilation tube placement: randomized study

Ti̇mpanoskleroz Etyoloji̇si̇nde Allerji̇ni̇n Yeri̇

The Effect of Alpha-Lipoic Acid on Myringosclerosis in a Rat Model

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