Tyndallometrie und Zellzahlmessung in der Vorderkammer bei Amotio retinae

Amann, Thomas; Nguyen, Nhung X.; Küchle, Michael

doi:10.1055/s-2008-1035012

Cited by 14 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consequently, we can assume that the extent of the blood-retinal barrier disruption is associated with the extent of retinal detachment. Similar findings are shown by other studies, 9,[16][17][18] which found a correlation between the extension of the retinal detachment and the tyndallometric values. However, the studies feature few patient numbers or define the extent of retinal detachment only sparingly.…”

Section: Discussionsupporting

confidence: 92%

Association between blood-aqueous barrier disruption and extent of retinal detachment

Schoeneberger

Eberhardt

Menghesha

et al. 2022

European Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose To investigate the association between anatomical features of rhegmatogenous retinal detachment (RRD) and the extent of blood-aqueous barrier disorder measured by non-invasiv laser flare photometry. Methods Retrospective evaluation of consecutive patients with RRD that underwent surgery between November 2016 and October 2018. Descriptive evaluation of pre- and postoperative parameters and correlation to preoperative laser flare value, extent of retinal detachment and re-detachment rate were performed. Results 266 patients (mean age 62.73 ± 10.40 years, 62.8% male) were included. Mean preoperative flare value was 11.0 ± 11.9 pc/ms. In pseudophakia flare values were higher than in phakia (12.7 ± 10.4 pc/ms versus 9.8 ± 12.9 pc/ms; p = 0.042). Flare increased and correlated significantly with the number of affected retinal quadrants (Q) (1 Q 6.4 ± 3.3 pc/ms; 2 Q 10.5 ± 8.8 pc/ms; 3 Q 15.6 ± 9.1 pc/ms; 4 Q 27.5 ± 33.3 pc/ms; p < 0.001; r = 0.40). Macular status correlated significantly with flare values (macula on 8.6 ± 7.1 pc/ms, off 13.1 ± 15.0 pc/ms; p = 0.004; r = 0.17). Conclusion The level of objective tyndallometry in RRD seems to be influenced by lens status and extent of retinal detachment. Thus, the greater the affected retinal area is, the more blood-aqueous barrier disruption seems to be present.

show abstract

Section: Discussionsupporting

confidence: 92%

Association between blood-aqueous barrier disruption and extent of retinal detachment

Schoeneberger

Eberhardt

Menghesha

et al. 2022

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…On the other hand, the inclusion of only RRD patients is a limitation of this study. Care must be taken in extrapolating the results to T2DM patients and controls without RRD since the blood-retinal barrier may be disrupted to varying degrees in RRD[49,50]. Furthermore, our results concerning free AGEs and α-dicarbonyls should be interpreted with caution.…”

Section: Discussionmentioning

confidence: 99%

Vitreous advanced glycation endproducts and α-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls

et al. 2017

View full text Add to dashboard Cite

PurposeAdvanced glycation endproducts (AGEs) and their precursors α-dicarbonyls are implicated in the progression of diabetic retinopathy. The purpose of this study was to assess AGEs and α-dicarbonyls in the vitreous of patients with type 2 diabetes mellitus (T2DM) with early stages or absence of diabetic retinopathy.MethodsWe examined vitreous samples obtained during vitrectomy from 31 T2DM patients presenting themselves with rhegmatogenous retinal detachment and compared these to 62 non-diabetic rhegmatogenous retinal detachment patients, matched on age, estimated glomerular filtration rate, smoking, intra-ocular lens implantation, and proliferative vitreoretinopathy. AGEs (pentosidine, Nε-(carboxymethyl)lysine, Nε-(carboxyethyl)lysine, and 5-hydro-5-methylimidazolone) and α-dicarbonyls (3-deoxyglucosone, methylglyoxal, and glyoxal) were measured by ultra performance liquid chromatography or high performance liquid chromatography. Skin autofluorescence was measured by the AGE Reader.ResultsMean age was 64 ± 7.6 years for T2DM patients and 63 ± 8.1 years for controls. For T2DM patients, median diabetes duration was 2.2 (0.3–7.4) years. Non-proliferative diabetic retinopathy was present in 1 patient and classified as absent or background retinopathy in 30 patients. Vitreous levels of pentosidine (2.20 vs. 1.59 μmol/mol lysine, p = 0.012) and 3-deoxyglucosone (809 vs. 615 nmol/L, p = 0.001) were significantly elevated in T2DM patients compared to controls. Other AGEs and α-dicarbonyls in the vitreous were not significantly different. There was a trend for increased skin autofluorescence in T2DM patients as compared to controls (p = 0.07).ConclusionsPentosidine and 3-deoxyglucosone concentrations were increased in the vitreous of rhegmatogenous retinal detachment patients with a relatively short duration of diabetes compared to non-diabetic rhegmatogenous retinal detachment patients.

show abstract

“…Die Untersuchungseinheit erlaubt eine exakte und reproduzierbare Messung des Proteingehaltes im Kammerwasser in vivo durch Messung der Streuung eines in die Vorderkammer gescannten He-Ne-Laser-Strahles mit einem Photomultiplier [13,23]. Details der Methodik, ihre Reproduzierbarkeit sowie ihre Anwendung bei einem breiten Spektrum von Augen-und Allgemeinerkrankungen sind in einer gröûeren Zahl von Publikationen unserer und anderer Arbeitsgruppen belegt [1,13,15,17,19,20,23]. Die Messungen wurden von insgesamt vier mit dem Untersuchungsgerät gut vertrauten ¾rzten durchgeführt, jeweils fünf Einzelmessungen wurden gemittelt.…”

Section: Patienten Und Methodenunclassified

Lasertyndallometrische Analyse der Blut-Kammerwasser-Schranke bei 31 Augen mit Heterochromiezyklitis Fuchs mit und ohne sekundäres Offenwinkelglaukom12

Küchle¹,

Nguyen²

2000

Klin Monatsbl Augenheilkd

Self Cite

View full text Add to dashboard Cite

The alteration of the blood-aqueous barrier in patients with Fuchs' heterochromic uveitis is unilateral and relatively mild, corresponding to the well-known clinical picture of the disease. Secondary open-angle glaucoma appears not to be associated with additional increase of aqueous flare. The unilaterality and the relatively homogeneous distribution of the degree of increased aqueous flare values support the clinical impression that Fuchs' heterochromic uveitis is a distinct clinical entity that should be differentiated from other variants of chronic anterior uveitis.

show abstract

Tyndallometrie und Zellzahlmessung in der Vorderkammer bei Amotio retinae

Cited by 14 publications

References 0 publications

Association between blood-aqueous barrier disruption and extent of retinal detachment

Association between blood-aqueous barrier disruption and extent of retinal detachment

Vitreous advanced glycation endproducts and α-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls

Lasertyndallometrische Analyse der Blut-Kammerwasser-Schranke bei 31 Augen mit Heterochromiezyklitis Fuchs mit und ohne sekundäres Offenwinkelglaukom12

Contact Info

Product

Resources

About