TypA is a virulence regulator and is present in many pathogenic bacteria

Scott, Kimberly A.; Ma, Diggle; Clarke, Stuart C.

doi:10.1080/09674845.2003.11978047

Cited by 13 publications

(11 citation statements)

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“…TypA, also named BipA, belongs to a superfamily of ribosome-binding GTPases within the TRAFAC class (translation factors) of GTPases [77], [78]. TypA has been suggested to be involved in the regulation of virulence and stress responses in pathogenic E. coli [79], Salmonella enterica Serovar Typhimurium [80] and Pseudomonas aeruginosa [81], and stress responses in non-pathogenic S. meliloti [82] and Bacillus subtilis [83]…”

Section: Resultsmentioning

confidence: 99%

RNA-Seq and Microarrays Analyses Reveal Global Differential Transcriptomes of Mesorhizobium huakuii 7653R between Bacteroids and Free-Living Cells

et al. 2014

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Mesorhizobium huakuii 7653R occurs either in nitrogen-fixing symbiosis with its host plant, Astragalus sinicus, or free-living in the soil. The M. huakuii 7653R genome has recently been sequenced. To better understand the complex biochemical and developmental changes that occur in 7653R during bacteroid development, RNA-Seq and Microarrays were used to investigate the differential transcriptomes of 7653R bacteroids and free-living cells. The two approaches identified several thousand differentially expressed genes. The most prominent up-regulation occurred in the symbiosis plasmids, meanwhile gene expression is concentrated to a set of genes (clusters) in bacteroids to fulfill corresponding functional requirements. The results suggested that the main energy metabolism is active while fatty acid metabolism is inactive in bacteroid and that most of genes relevant to cell cycle are down-regulated accordingly. For a global analysis, we reconstructed a protein-protein interaction (PPI) network for 7653R and integrated gene expression data into the network using Cytoscape. A highly inter-connected subnetwork, with function enrichment for nitrogen fixation, was found, and a set of hubs and previously uncharacterized genes participating in nitrogen fixation were identified. The results described here provide a broader biological landscape and novel insights that elucidate rhizobial bacteroid differentiation, nitrogen fixation and related novel gene functions.

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Section: Resultsmentioning

confidence: 99%

RNA-Seq and Microarrays Analyses Reveal Global Differential Transcriptomes of Mesorhizobium huakuii 7653R between Bacteroids and Free-Living Cells

et al. 2014

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“…The virulence regulator BipA (Q83D58), a highly conserved GTPase that functions to influence numerous cellular processes, was identified in this study. In both Escherichia coli and Salmonella enterica, BipA has been implicated in controlling bacterial motility, modulating attachment and effacement, upregulating expression of virulence genes, and mediating avoidance of host defense mechanisms [69,70]. The regulatory mechanisms are themselves complex, and involve both transcription and translation.…”

Section: 4mentioning

confidence: 99%

Proteomic comparison of virulent phase I and avirulent phase II of Coxiella burnetii, the causative agent of Q fever

Škultéty

Hajdúch

Flores-Ramirez

et al. 2011

Journal of Proteomics

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“…BipA, also known as TypA, is a highly conserved prokaryotic GTPase that functions to regulate numerous actions in bacteria (16,46). It is a member of the family of bacterial translational GTPases.…”

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confidence: 99%

Salmonella entericaSerovar Typhimurium BipA Exhibits Two Distinct Ribosome Binding Modes

deLivron

Robinson

2008

J Bacteriol

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BipA is a highly conserved prokaryotic GTPase that functions to influence numerous cellular processes in bacteria. In Escherichia coli and Salmonella enterica serovar Typhimurium, BipA has been implicated in controlling bacterial motility, modulating attachment and effacement processes, and upregulating the expression of virulence genes and is also responsible for avoidance of host defense mechanisms. In addition, BipA is thought to be involved in bacterial stress responses, such as those associated with virulence, temperature, and symbiosis. Thus, BipA is necessary for securing bacterial survival and successful invasion of the host. Steadystate kinetic analysis and pelleting assays were used to assess the GTPase and ribosome-binding properties of S. enterica BipA. Under normal bacterial growth, BipA associates with the ribosome in the GTP-bound state. However, using sucrose density gradients, we demonstrate that the association of BipA and the ribosome is altered under stress conditions in bacteria similar to those experienced during virulence. The data show that this differential binding is brought about by the presence of ppGpp, an alarmone that signals the onset of stress-related events in bacteria.

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TypA is a virulence regulator and is present in many pathogenic bacteria

Cited by 13 publications

References 0 publications

RNA-Seq and Microarrays Analyses Reveal Global Differential Transcriptomes of Mesorhizobium huakuii 7653R between Bacteroids and Free-Living Cells

RNA-Seq and Microarrays Analyses Reveal Global Differential Transcriptomes of Mesorhizobium huakuii 7653R between Bacteroids and Free-Living Cells

Proteomic comparison of virulent phase I and avirulent phase II of Coxiella burnetii, the causative agent of Q fever

Salmonella entericaSerovar Typhimurium BipA Exhibits Two Distinct Ribosome Binding Modes

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