Type 1 Diabetes

Delli, Mph Ahmed J.; Larsson, Helena; Ivarsson, Sten-A.; MBChB, Mrcp Alice P. S. Kong; Therapeutics,

doi:10.1002/9781444324808.ch9

Cited by 5 publications

(3 citation statements)

References 200 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Type I diabetes is an autoimmune disease characterized by a local inflammatory reaction in and around islets that is followed by selective destruction of insulinsecreting β cells. Type II diabetes is characterized by peripheral insulin resistance and impaired insulin secretion [3].…”

Section: Introductionmentioning

confidence: 99%

The Effect Of Roselle Extract (Hibiscus sabdariffa Linn.) On Blood Glucose Level And Total Antioxidant Level On Diabetic Rat Induced By Streptozotocin

Zakaria¹,

Prangdimurti²,

Damanik³

2014

iosrphr

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

The Effect Of Roselle Extract (Hibiscus sabdariffa Linn.) On Blood Glucose Level And Total Antioxidant Level On Diabetic Rat Induced By Streptozotocin

Zakaria¹,

Prangdimurti²,

Damanik³

2014

iosrphr

View full text Add to dashboard Cite

show abstract

“…However, 85% of newly diagnosed diabetics do not have a family history of the disease. [20] Solely targeting T1D first-degree relatives (FDR) would therefore miss a large proportion of prospective cases and would require a large geographical footprint to yield an adequate sample size. This problem was resolved by creating a genetic risk score (GRS) based on 47 single nucleotide polymorphisms (SNP) that enables stratifying T1D risk.…”

Section: Genetic Risk Scorementioning

confidence: 99%

Successful incorporation of a genetic risk prediction research platform into routine newborn screening

Bendor‐Samuel

Wishlade

Willis

et al. 2021

Preprint

View full text Add to dashboard Cite

An increasing number of diseases can be offered treatments that are transformative if administered in a timely manner. However, many of these diseases are currently not included in the newborn screening programs because they lack sensitive and specific metabolic biomarkers and their detection relies on genetic methods. Type 1 diabetes (T1D) constitutes a potential example of such disease.Between April 2018 and November 2020, over 15500 babies were enrolled into ‘INGR1D’ (Investigating Genetic Risk for T1D), a research study to identify newborns with an increased genetic risk of T1D. This project, performed as part of a T1D primary prevention study (the Primary Oral Insulin Trial, POInT), has helped to pioneer the integration of genetic screening into the NHS Newborn Blood Spot Screening Programme (NBSSP) for consenting mothers, without affecting the screening pathway. The use of prospective consent to perform personalised genetic testing on samples obtained through the routine NBSSP represents a novel mechanism for clinical genetic research in the UK and provides a model for further population based genetic studies in the newborn.This project builds on the UK’s role as a world leader in genomic medicine, e.g. through its inception and completion of the 100 000 Genomes Project, and its subsequent ambition to map 5 million further genomes over the next 5 years.Our aim is therefore to describe the methodology used by INGR1D as a way to demonstrate how a successful research and clinical trial tool can be integrated into a national screening programme, with the potential for the tool to be developed to incorporate multiple diseases with genetic markers without altering the screening pathway.

show abstract

“…Because patients with one organ-specific autoimmune disease are at risk of developing other autoimmune disorders, and thyroid disorders are more common in females, it is not surprising that up to 30% of female type1 diabetic patients have thyroid disease. 5,6 A number of reports have also indicated a higher than normal prevalence of thyroid disorders in type 2 diabetic patients, with hypothyroidism especially subclinical being the most common disorder.…”

Section: Introductionmentioning

confidence: 99%

Correlates of thyroid disorder in type DM patients

Gundagatti¹,

Pandey²,

Av³

et al. 2021

Int. J. Adv. Res. Med.

View full text Add to dashboard Cite

Diabetic patients have a higher prevalence of thyroid disorders compared with the normal population. Because patients with one organ-specific autoimmune disease are at risk of developing other autoimmune disorders, and thyroid disorders are more common in females, it is not surprising that up to 30% of female type1 diabetic patients have thyroid disease. A thorough clinical examination including vitals, general physical examination, systemic examination and investigations was carried out. Biochemical investigations were carried out using proper aseptic precautions for collecting blood. It is seen that, in the present study patients were divided into 2 groups based on duration of diabetes. There were 52 diabetic patients in ≤3 months group, of which 40 patients were euthyroids and 12 patients had thyroid dysfunction. There were 58 diabetic patients in ≥3 months group, of which 44 patients were euthyroids and 14 patients had thyroid dysfunction. However there was no statistically significant difference between these two groups.(p value was 1.00).

show abstract

Type 1 Diabetes

Cited by 5 publications

References 200 publications

The Effect Of Roselle Extract (Hibiscus sabdariffa Linn.) On Blood Glucose Level And Total Antioxidant Level On Diabetic Rat Induced By Streptozotocin

The Effect Of Roselle Extract (Hibiscus sabdariffa Linn.) On Blood Glucose Level And Total Antioxidant Level On Diabetic Rat Induced By Streptozotocin

Successful incorporation of a genetic risk prediction research platform into routine newborn screening

Correlates of thyroid disorder in type DM patients

Contact Info

Product

Resources

About