Type 1 Diabetes, Cardiovascular Complications and Sesame (芝麻 Zhī Má)

Abstract

Diabetes is a major concern among medical practitioners, with the annual mortality rate increasing up to 26.9% in a person aged 65 years or older and 11.3% in the adult. There are many serious complications associated with diabetes, particularly cardiovascular complications due to microvascular diseases. A prerequisite to reduce the risk of microvascular and neurologic complications of type 1 diabetes is normoglycemia. Insulin therapy is the most common treatment used nowadays in type 1 diabetes. However, this method still has many disadvantages such as increased episode of severe hypoglycemia, hypoglycemia unawareness, increased weight gain, transient exacerbation of pre-existing retinopathy, etc. Using insulin pump (the insulin pump is a medical device used for continuous subcutaneous insulin infusion to manage the insulin level in the treatment of diabetes mellitus), is associated with known disadvantages including increased ketoacidosis, infection at the infusion site, and the treatment being less suitable in young children (less than 7 years of age). Therefore, alternative treatment for diabetes is still in great demand. We took the approach of traditional Chinese medicine to discuss this matter. Sesame (芝麻 Zhī Má), a herb, has been used medicinally for thousands of years in almost all the countries in the world. The beneficial effects of sesame in remediating diabetes, such as hypoglycemic effects, antioxidant, anti-inflammatory, and hypolipidemic effects, improving fat metabolism, and reducing cholesterol, have been demonstrated in many studies,. However, reports on the effects of sesame in remediating cardiovascular complications in diabetic patients are limited, which necessitates further studies on the effects of sesame on cardiovascular complications.

Dyslipidemia in young patients with type 1 diabetes mellitus

“…Better GC is associated with improved survival in patients with T1D, leading to progressive changes in the causes of mortality, particularly cardiovascular disease; therefore, it is important to identify the risk factors for cardiovascular disease in this population (25)(26)(27)(28)(29)(30)(31).…”

Dough Characteristics, Baking Performance, and Staling of Taftoon Bread as Affected by Supplementation with Sesame Oil

“…Sesame oil consumption increases plasma gamma-tocopherol and enhances vitamin E activity that is believed to prevent cancer and heart disease. It is also known to reduce blood cholesterol due to the high polyunsaturated fat content in the oil (Lin, Thuy, Wang, & Huang, 2014).…”

Development of functional cookies with wheat flour, banana flour (Musa paradisiaca), sesame seeds (Sesamum indicum) and storage stability

“…Once extracted the oil, a cake is obtained, rich in proteins for the human and animal consumption, being in them about 15 amino acids; Is used to a lesser extent in the preparation of antioxidants, cosmetics and medicines, is used in bakeries, pastry shops (Gharby et al, 2017). Of its lipid content, 80% belongs to polyunsaturated fats mainly linoleic acid and less alphalinolenic (omega 6 and 3), these essential fatty acids make possible the regulation of cholesterol levels in the blood, consumption of sesame oil can reduce the risk of coronary vascular, diabetes and hypertension disease (Lin et al, 2014). Sesame seeds are known to exhibit various health beneficial properties, including hypocholesterolaemic, hepatoprotective, and antimutagenic effects (Kim et al, 2014).…”