2018
DOI: 10.2174/1573399813666170609100219
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Type 1 Diabetes Treatments Based on Stem Cells

Abstract: In the present review, we will overview the studies on stem cell and their effects in the treatment of diabetes in order to discuss the questions generated about their origin and the mechanisms that are involved in their reparative properties.

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“…In this regard, most researchers have considered MSCs as a very attractive cell source in the treatment of pancreas diseases. 8,9 Multiple types of cells can be differentiated from MSCs in vitro.…”
Section: Introductionmentioning
confidence: 99%
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“…In this regard, most researchers have considered MSCs as a very attractive cell source in the treatment of pancreas diseases. 8,9 Multiple types of cells can be differentiated from MSCs in vitro.…”
Section: Introductionmentioning
confidence: 99%
“…One of the most important key members of adult stem cells is mesenchymal stem cells (MSCs). In this regard, most researchers have considered MSCs as a very attractive cell source in the treatment of pancreas diseases . Multiple types of cells can be differentiated from MSCs in vitro.…”
Section: Introductionmentioning
confidence: 99%
“…Notch signaling plays a pivotal role in pancreas development by regulating progenitor proliferation and cell fate decisions and thus ensures the precise and timely regulation of the cell number of each lineage, which is ultimately crucial for proper organ function [1]. The juxtacrine Notch signaling pathway is characterized by signal sending from one cell via the DSL (Delta/Serrate/LAG-2)-family of ligands.…”
Section: Introductionmentioning
confidence: 99%