2008
DOI: 10.1098/rstb.2008.2270
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Type-1 metabotropic glutamate receptor in cerebellar Purkinje cells: a key molecule responsible for long-term depression, endocannabinoid signalling and synapse elimination

Abstract: The cerebellum is a brain structure involved in the coordination, control and learning of movements, and elucidation of its function is an important issue. Japanese scholars have made seminal contributions in this field of neuroscience. Electrophysiological studies of the cerebellum have a long history in Japan since the pioneering works by Ito and Sasaki. Elucidation of the basic circuit diagram of the cerebellum in the 1960s was followed by the construction of cerebellar network theories and finding of their… Show more

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Cited by 106 publications
(119 citation statements)
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References 143 publications
(222 reference statements)
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“…Cerebellar LTD has been intensely studied, and certain key events have to take place to induce LTD at the parallel fiber-Purkinje cell synapse, including activation of postsynaptic mGluR1 receptors at the parallel fiber-Purkinje cell synapse. This ultimately leads to the internalization of AMPA receptors at this synapse, thereby causing LTD of the AMPA receptor-dependent fast EPSP (16,17).…”
Section: Canonical Transient Receptor Potential (Trpc)mentioning
confidence: 99%
“…Cerebellar LTD has been intensely studied, and certain key events have to take place to induce LTD at the parallel fiber-Purkinje cell synapse, including activation of postsynaptic mGluR1 receptors at the parallel fiber-Purkinje cell synapse. This ultimately leads to the internalization of AMPA receptors at this synapse, thereby causing LTD of the AMPA receptor-dependent fast EPSP (16,17).…”
Section: Canonical Transient Receptor Potential (Trpc)mentioning
confidence: 99%
“…Thus, the presence of LTZ per se in the bath did not modify the passive and synaptic properties of PCs. E2 synthesis inhibition prevents PF-LTP without altering PF-LTD Next, we investigated LTZ influence on cerebellar PF-LTD and PF-LTP, which are two plastic mechanisms thought to be responsible for encoding the VOR gain increase and decrease adaptation, respectively (Broussard et al 2011;Hansel et al 2001;Kano et al 2008;Titley et al 2010). …”
Section: E2 Synthesis Inhibition Does Not Affect Intrinsic and Synaptmentioning
confidence: 99%
“…[41][42][43] Similar to the study by Antoun et al, the work of Yamamoto et al focused solely on the PKC-MAPK signaling axis, and did not address the potential contribution of RKIP to other signaling pathways that participate in cerebellar LTD induction. For instance, GRK2 has been shown to desensitize the metabotropic glutamate receptor, mGluR1, a key player in cerebellar LTD. 44,45 Future studies should address whether RKIP-dependent modulation of GRK2 activity is working in concert with the PKC-MAPK positive feedback mechanism to drive LTD induction.…”
Section: Rkip and Long-term Depressionmentioning
confidence: 99%