1992
DOI: 10.1002/ijc.2910500209
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Type‐1 plasminogen activator inhibitor in human breast carcinomas

Abstract: We have investigated the occurrence of type-1 inhibitor of plasminogen activators (PAI-1) in human breast tumors. PAI-1 levels, measured by enzyme-linked immunosorbent assay, were significantly higher in malignant breast carcinomas (n = 178) than in benign breast tumors (n = 25). The levels of PAI-1 were found to be correlated with those of urokinase-type plasminogen activator (u-PA). The presence of PAI-1 in tumor extracts was also demonstrated by immunoblotting analysis. Immunohistochemical investigations by… Show more

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Cited by 96 publications
(50 citation statements)
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“…As with PAI-1 (Reilly et al, 1992), we show here that PAI-2 protein levels are also significantly correlated with those for uPA in breast cancer. However, the relationship between PAI-2 and uPA is less strong than that between PAI-I and uPA.…”
Section: Discussionsupporting
confidence: 69%
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“…As with PAI-1 (Reilly et al, 1992), we show here that PAI-2 protein levels are also significantly correlated with those for uPA in breast cancer. However, the relationship between PAI-2 and uPA is less strong than that between PAI-I and uPA.…”
Section: Discussionsupporting
confidence: 69%
“…Relatively little work appears to have been published on the detection of PAI-2 by immunocytochemistry in breast cancer. Using unprocessed tissue we previously found, using both monoclonal and polyclonal antibodies, that PAI-i was mostly confined to tumour cells in breast cancer (Reilly et al, 1992). However, using paraffin-embedded tissue Bianchi et al (1995) found that PAI-i was predominantly located in stromal cells, although epithelial cell staining was also present.…”
Section: Discussionmentioning
confidence: 95%
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“…The remodelling it involves requires the coordinated action of cell-secreted proteolytic enzymes and their inhibitors. Elevated levels of urokinase-type plasminogen activator (uPA) have been implicated in these invasive processes (Dano et al, 1985;Duffy, 1987;Layer et al, 1987;Markus et al, 1988;Pyke et al, 1991b), and plasminogen activator inhibitor type 1 (PAI-1) has been found in many types of malignant tissue (Kruithof et al, 1988;Cubellis et al, 1990;Foucre et al, 1991;Tanaka et al, 1991;Reilly et al, 1992). Plasminogen activator inhibitor type 2 (PAI-2) is one of the primary physiological inhibitors of uPA.…”
mentioning
confidence: 99%