Type 2 diabetes among North adolescents: An epidemiologic health perspective

Fagot-Campagna, A.; Pettitt, David J.; Engelgau, Michael M.; Burrows, Nilka Ríos; Geiss, Linda S.; Valdéz, Rodolfo; Beckles, Gloria L.; Saaddine, Jinan B.; Gregg, Edward W.; Williamson, David F.; Narayan, K.M. Venkat

doi:10.1067/mpd.2000.105141

Cited by 1,033 publications

(662 citation statements)

References 12 publications

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“…Thus, it is possible that being obese in childhood may have an independent (of adult BMI) effect on future diabetes risk that we are unable to detect in this cohort. The emergence of type 2 diabetes in obese children [3,4] is a clear indicator that one cannot be complacent about the risk associated with obesity in childhood.…”

Section: Discussionmentioning

confidence: 99%

“…More recently, a study found that extreme preterm birth (≤32 weeks) was associated with insulin resistance in childhood (age 4-10 years) [2], but to our knowledge, no previous study has examined the association of gestational age with adult diabetes. Childhood BMI has been found to be positively associated with glucose intolerance in childhood [3,4], but few studies have examined its association with later diabetes in adulthood.…”

Section: Introductionmentioning

confidence: 99%

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The associations of birthweight, gestational age and childhood BMI with type 2 diabetes: findings from the Aberdeen Children of the 1950s cohort

et al. 2006

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Aims/hypothesis The aim of this study was to examine the associations of birthweight, gestational age and childhood BMI (assessed at a mean age of 5 years) with a self-report of a doctor diagnosis of diabetes in middle age. Methods We studied a birth cohort of 5,793 individuals who were born between 1950 and 1956 in Aberdeen, Scotland, and who responded to a questionnaire administered in 2000. Results Birthweight and gestational age were inversely associated with diabetes. These associations remained with additional adjustment for indicators of childhood and adult socioeconomic position, maternal complications of pregnancy, adult smoking, adult BMI and simultaneous adjustment for each other: the adjusted odds ratio per unit increase in birthweight z score was 0.73 (95% CI 0.60-0.88), the odds ratio per week increase in gestational age was 0.91 (95% CI 0.82-1.00) and odds ratio for preterm birth was 2.04 (94% CI 1.18-3.53). The positive association of childhood BMI with diabetes was attenuated on adjustment for adult BMI. Conclusions/interpretationIn this population, who were born in the 1950s, poor intrauterine growth and preterm birth are associated with an increased risk of diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The associations of birthweight, gestational age and childhood BMI with type 2 diabetes: findings from the Aberdeen Children of the 1950s cohort

et al. 2006

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“…4 Genetic and environmental factors are of importance for the development of obesity and T2D, as higher prevalences are found in certain ethnic groups and are associated with lower socioeconomic status. [5][6][7] In 15-to 19-year-old Pima Indians from Arizona, 5.1% were diagnosed with T2D, 8 and in a US cohort of eighth-grade students, who were predominantly minority, the prevalence of impaired glucose regulation and T2D reached 440%. 9 For most European countries, population-based data on T2D prevalence in youth are not available, so that it is currently unknown whether the situation is similarly alarming in Europe.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of impaired glucose regulation in German school-leaving students

et al. 2007

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The increase in prevalence of obesity in childhood and adolescence appears to be followed by a rise of type 2 diabetes (T2D) cases in youth. Studies from the United States indicated that more than 1 in 10 adolescents may have disturbed glucose metabolism and that ethnicity and socioeconomic status are major determinants of (pre) diabetes prevalence. Since data for European countries are rare, we conducted a cross-sectional survey in 721 school-leaving boys and girls (mean age 15.5 years) in Düsseldorf (Germany). In our population from a predominantly low socioeconomic background, a total of 2.5% had impaired fasting glucose, impaired glucose tolerance or T2D.

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“…[1][2][3] Being overweight or obese in adult life also increases the risk of these conditions 4,5 and there is accumulating evidence indicating that weight in pre-adult and early adult life also affect later adult-onset conditions. 6,7 However, among participants in the US Nurses Health Study body mass index, based on self-report of weight and height in a questionnaire when the participants were aged 30-55, was strongly associated with diabetes risk during eight years of follow-up, but body mass index when the nurses were 18 years of age (based on retrospective report of their earlier weight by the nurses at the baseline examination) was only weakly associated with future risk of diabetes, with this risk attenuating to the null with adjustment for later body mass index. 8 Taken together, these observations imply that people who subsequently develop diabetes have a different growth trajectory or excess weight gain over the lifecourse in comparison with the rest of the population.…”

Section: Introductionmentioning

confidence: 99%

Lifecourse weight patterns and adult-onset diabetes: the Glasgow Alumni and British Women's Heart and Health studies

et al. 2005

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Objective: To examine the association between body weight measures across the lifecourse and the risk of adult-onset diabetes. Methods: We analysed data from the Glasgow Alumni Cohort and the British Women's Heart and Health Study (BWHHS). The former included 5571 men and women who had height and weight measured at university, and reported birthweight, mid-and later-life weight in a postal questionnaire. The BWHHS analysis included 4280 women who had height and weight measured in later adulthood and recalled their birthweight and early adult height and weight. Adult-onset diabetes was defined as doctordiagnosed disease after age 30, either self-reported or abstracted from medical records. Results: Thirty nine women and 209 men (Glasgow Alumni study) and 314 women (BWHHS) had diabetes. Those with diabetes had lower mean birthweight than those without, although the differences were small. Individuals with diabetes were also shorter and heavier at all ages than those without diabetes. Being overweight during at least one time period in adult life was associated with an increased risk of diabetes, compared to those who were never overweight. While there was no age at which being overweight was particularly detrimental, the risk associated with being overweight was cumulative across the lifecourse. Conclusions: Being overweight at any point during life is associated with an increased risk of adult-onset diabetes. The cumulative nature of this association reinforces the need to prevent the development of excess weight at an early age to reduce diabetes prevalence in coming decades.

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Type 2 diabetes among North adolescents: An epidemiologic health perspective

Cited by 1,033 publications

References 12 publications

The associations of birthweight, gestational age and childhood BMI with type 2 diabetes: findings from the Aberdeen Children of the 1950s cohort

The associations of birthweight, gestational age and childhood BMI with type 2 diabetes: findings from the Aberdeen Children of the 1950s cohort

Prevalence of impaired glucose regulation in German school-leaving students

Lifecourse weight patterns and adult-onset diabetes: the Glasgow Alumni and British Women's Heart and Health studies

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