Type 2 diabetes and exercise unexplained dyspnoea: a new focus under the lens with a long way to go yet

Guazzi, Marco; Arena, Ross

doi:10.1093/eurjpc/zwac177

Cited by 1 publication

(1 citation statement)

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“…However, there are few data on the impact of altered spirometric parameters on the sensation of breathlessness in patients with T2D, and whether it is associated with the other late complications of diabetes. In addition, these studies have been conducted using different tools and including patients with pulmonary disease or cardiac disease ( 12 , 13 ). For this reason, our aim was to evaluate the clinical impact of T2D on dyspneic sensation by administering two well-validated questionnaires as the modified medical research council (mMRC) dyspnea scale and the Saint George’s Respiratory Questionnaire (SGRQ) ( 14 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

Assessment of dyspneic sensation in patients with type 2 diabetes

Mizab,

Sánchez,

Gutiérrez-Carrasquilla

et al. 2023

Front. Endocrinol.

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IntroductionIndividuals with type 2 diabetes (T2D) should be considered a susceptible group for pulmonary dysfunction. So, we aimed to evaluate the sensation of breathlessness in this population by administering two well-validated questionnaires.MethodsThis is a crosssectional study with 592 people without known respiratory disease (353 with T2D) who answered the modified Medical Research Council (mMRC) questionnaire. In addition, 47% also responded to the St George Respiratory Questionnaire, a specific instrument designed to be applied to patients with obstructive airway disease.ResultsPatients with T2D showed a higher mMRC score in comparison to the control group [1.0 (0.0 – 4.0) vs. 0.0 (0.0 – 4.0), p<0.001]. A higher prevalence of subjects with mMRC ≥2 was observed in T2D that in the control group (20.2% vs. 11.6%, p=0.004). Participants with T2D and mMRC ≥2 showed a higher HbA1c (8.2 ± 1.6% vs. 7.8 ± 1.6%, p=0.048), longer T2D evolution and higher prevalence of nephropathy. In the multivariate analysis, the presence of T2D [OR=1.95 (1.19 to 3.22), p=0.008] in all the population, and HbA1c [OR=1.19 (1.01 to 1.41), p=0.034] and the presence of diabetic nephropathy [OR=2.00 (1.14 to 3.52), p=0.015] in patients with T2D, predicted a mMRC ≥2. Finally, no differences were observed regarding the SGRQ score among groups.ConclusionsPatients with T2D showed a greater sensation of dyspnea than subjects with normal carbohydrate metabolism. Risk factors included poor metabolic control and the presence of renal disease.

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