Type 2 diabetes and its correlates in a first nationwide study among Cypriot adults

Andreou, Elena; Papandreou, Dimitrios; Hajigeorgiou, Photos G.; Kyriakou, K.; Avraam, Thalia; Chappa, G.; Kallis, P.; Lazarou, Christalleni; Philippou, Christiana; Christoforou, Christoforos; Kokkinofta, Rebecca; Dioghenous, Christos; Savva, Savvas; Kafatos, Antony; Zampelas, Antonis

doi:10.1016/j.pcd.2017.01.001

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…The overall effect of hypertension was OR = 2.73 (95% CI : 2.25–3.36), suggesting a close link between hypertension and type 2 diabetes; this finding is in agreement with previous reports [46,50] indicating a close predictive association between hypertension and type 2 diabetes. The comorbidity of hypertension with type 2 diabetes could be ascribed to adiposity and insulin resistance via the shared pathophysiological mechanisms, for example, inappropriate activation of the renin-angiotensin-aldosterone system, [51] which is consistent with our results regarding obesity.…”

Section: Discussionsupporting

confidence: 92%

“…[55] Our study confirmed this relationship and showed a comparatively strong link of OR = 2.23 (95% CI : 1.70–2.91), which is in accordance with the result of OR = 2.93 (95% CI : 2.37–3.63) from a recent cross-sectional survey in Shanghai, China. [56] Hypercholesterolemia and hypertriglyceridemia, 2 common patterns of dyslipidemia, showed estimated effects consistent with those of previous studies, [50,57] with only some differences in magnitude. Although the estimated values of hypercholesterolemia and hyperglyceridemia tended to approach each other, type 2 diabetes seemed to prevail more frequently in those with hyperglyceridemia those with hypercholesterolemia, except in 2006 to 2010.…”

Section: Discussionsupporting

confidence: 87%

“…This difference could also be observed in the regional stratification results; the southern region appeared to have smaller magnitudes for dyslipidemia, hypercholesterolemia and hypertriglyceridemia. Other patterns concerning dyslipidemia have also been reported, such as for high-density lipoprotein cholesterol (HDL-C), [50] the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C), [58] and the ratio of cholesterol to high-density lipoprotein cholesterol (TC/HDL-C), [57] yet the index that can better indicate the relationship between dyslipidemia and type 2 diabetes has yet to be determined.…”

Section: Discussionmentioning

confidence: 99%

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Meta-analytic evaluation for the spatio-temporal patterns of the associations between common risk factors and type 2 diabetes in mainland China

Zhou¹,

Xiang

Liu³

et al. 2019

Medicine

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There is a dearth of accurate information about the associations between risk factors and type 2 diabetes in mainland China. We conducted a systematic review and meta-analysis to explore the spatio-temporal patterns of the associations between common risk factors and type 2 diabetes in adults at least 18 years old in mainland China. We searched English and Chinese databases from January 1st, 1997 to December 31st, 2017 for relevant observational studies. Overall and stratification analyses including secular trends and temporal distributions were conducted, odds ratio (OR) and 95% confidence interval (CI) were calculated by applying random-effects model. Thirty-five studies were included. Type 2 diabetes was positively associated with a family history of type 2 diabetes ( OR 2.89, 95% CI 2.38–3.49), hypertension ( OR 2.73, 95% CI 2.25–3.36), central obesity ( OR 2.28, 95% CI 1.94–2.68), dyslipidemia ( OR 2.23, 95% CI 1.70–2.91), hypertriglyceridemia ( OR 2.18, 95% CI 1.64–2.92), general obesity ( OR 1.90, 95% CI 1.66–2.18), hypercholesterolemia ( OR 1.65, 95% CI 1.32–2.06), smoking ( OR 1.26, 95% CI 1.13–1.40), and drinking ( OR 1.20, 95% CI 1.05–1.36), whereas a negative association with female gender ( OR 0.87, 95% CI 0.78–0.97) existed. Except for female gender and drinking, the pooled effects of temporal and spatial stratification for the other five risk factors were consistent with the above results. For temporal stratification, the OR s of general obesity increased gradually during the periods of 1992 to 2005, 2006 to 2010, and 2011 to 2017, while the OR s of a family history declined. For regional stratification, the magnitudes of OR s for hypertension, dyslipidemia, and hypercholesterolemia in northern areas were larger than that in southern areas, while opposite situation occurred for a family history. Except for the factor a family history, provincial results for the other nine risk factors differed from the overall results and among provinces. Effect differences existed for modifiable and non-modifiable risk factors in secular trends and regional distribution, which is of potential public health importance for type 2 diabetes prevention.

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Section: Discussionsupporting

confidence: 92%