Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study

Shestakova, Ekaterina A.; Алексеевна, Шестакова Екатерина; Lunina, Elena Yu; Юрьевна, Лунина Елена; Galstyan, Gagik R.; Радикович, Галстян Гагик; Shestakova, Marina Vladimirovna; Владимировна, Шестакова Марина; Dedov, Ivan I.; Иванович, Дедов Иван

doi:10.14341/dm12286

Cited by 30 publications

(4 citation statements)

References 9 publications

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“…С учетом того факта, что Россия относится к регионам с высокой распространенностью СД, определение гипергликемии во взрослой популяции имеет актуальное значение. По данным российского популяционного исследования NATION (Эпидемиологическое кросс-секционное исследование по оценке распространенности СД 2 типа у взрослого населения), частота развития СД 2 типа и предиабета в популяции РФ прогрессивно нарастает при сочетании нескольких наиболее значимых ФР, таких как возраст ≥45 лет, наличие ожирения и артериальной гипертонии [15].…”

Section: Discussionunclassified

Evaluation of lipid disorders and hyperglycemia in an open population aged 30-69 years: results of a multicenter study

Мамедов¹,

Sushkova

Isakov

et al. 2023

Cardiovasc Ther Prev

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Aim. To identify lipid metabolism disorders and hyperglycemia in the open population aged 30-69 in 5 cities of the Vladimir region, taking into account sex characteristics.Material and methods. The study included 1350 people (men and women aged 30-69 years), while 1174 people completed the study; the response rate was 87%. There were 424 (36,1%) men and 750 (63,9%) women among those completed the study. All participants were interviewed according to a standard questionnaire, including questions on socio-demographic status, behavioral and biological risk factors for cardiovascular diseases, as well as the presence of somatic diseases and their treatment. The blood concentrations of total cholesterol (TC), triglycerides, high-density lipoprotein (HDL) cholesterol and glucose were determined.Results. The average indicators of TC in the adult population were 5,28±0,75 mmol/l, for men and women its level was comparable. Sex differences were revealed in the average blood level of HDL-C. In the male population, its level was 1±0,11 mmol/l, and among women it was 1,14±0,14 mmol/l (p<0,001). The blood concentration of triglycerides was significantly higher compared to women — 1,8 [1,5; 2,1] mmol/l in men vs 1,7 [1,3; 2,0] mmol/l in women (p<0,035). In the examined adult population, 56,7% had an elevated TC level, while the prevalence of hypercholesterolemia among men and women was comparable — 57,8 and 55,7%, respectively. Hyperglycemia was found in 22% of all examined, while among men it was detected in every fourth, and among women in every fifth. Sex differences were significant (p=0,045). The prevalence of prediabetes among men is significantly higher compared to women — 17,2 and 11,9% (p=0,013), while the prevalence of diabetes in men and women was comparable — 7,3 and 7,6%, respectively.Conclusion. Every second participant among men and women of the Vladimir region population has hypercholesterolemia, while fasting hyperglycemia is detected in every fourth man and fifth woman. Among men, the incidence of prediabetes is 2,5 times, and among women 1,5 times higher than the prevalence of diabetes. Thus, development of preventive interventions in a particular region of the Central Federal District should take into account the high prevalence of hypercholesterolemia and hyperglycemia, including early disorders of carbohydrate metabolism.

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Section: Discussionunclassified

Evaluation of lipid disorders and hyperglycemia in an open population aged 30-69 years: results of a multicenter study

Мамедов¹,

Sushkova

Isakov

et al. 2023

Cardiovasc Ther Prev

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“…Diabetes mellitus is a serious threat to the health of people worldwide [ 23 , 24 , 25 ]. According to the latest statistics published in the Diabetes Atlas of the International Diabetes Federation (IDF) (ninth edition) (2019), 463 million adults are currently living with diabetes around the world [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Classification of the Diabetic Foot Syndrome Adapted to ICD-10 as a Solution to the Problem of Diagnostics, Statistics and Standardisation

Lukin¹,

Kuchumov

Zarivchatsky³

et al. 2021

Medicina

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Background and Objectives: To propose a new classification of diabetic foot syndrome adapted for inclusion in the ICD-10 (the ICD-10 is the 10th revision of the International Statistical Classification of Diseases) and providing more reliable data on the number of clinical cases. Materials and Methods: A randomized controlled trial was performed. A total of 180 patients (36.6%) discharged from the hospital after surgical treatment and 312 patients (63.4%) who applied independently were observed and analysed. All patients had type 2 diabetes and were comparable in gender, age, duration of diabetes, area and nature of the wound defect. Results: We proposed to add the following to the existing ICD-10 and the emerging ICD-11 codes: Edf10.0—insulin-dependent diabetes mellitus with diabetic foot syndrome and Edf11.0—non-insulin-dependent diabetes mellitus with diabetic foot syndrome, where “df” is an acronym for diabetic foot. The new classification designates the seven most frequent areas of the lesion and five degrees of depth of soft tissue lesions. Conclusions: The proposed classification adapted for ICD-10 will enable the standardisation of diagnosis, providing a complete picture of this complication of diabetes mellitus, determining the number of amputations and their validity. Accurate statistics will allow for objective funding and timely preventive measures.

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“…Ожирение является одним из наиболее значимых факторов риска развития сахарного диабета 2-го типа (СД 2). Тем не менее существует большая группа пациентов, у которых не развиваются нарушения углеводного обмена, несмотря на наличие ожирения: по данным исследования NATION, даже среди лиц с ожирением 3-й степени (индекс массы тела -ИМТ>40 кг/м 2 ) у 40,2% не обнаруживаются СД 2 или предиабетические нарушения углеводного обмена [1]. Можно предположить, что эти пациенты обладают защитным фенотипом, позволяющим длительно удерживать нормогликемию.…”

Section: ââåäåíèåunclassified

Obesity without diabetes: the role of hormonal regulation

Shestakova

Sklyanik

Panevina

et al. 2020

Terapevticheskii arkhiv

Self Cite

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Aim.Obese patients without diabetes present an interesting phenotype to explore protective mechanisms against type 2 diabetes (T2D) development. In our study we looked for specific hormonal features of obese patients without T2D. Materials and methods.We included 6 groups of patients with different metabolic profiles (n=212): controls with BMI25 kg/m2, HbA1c6%, age 30 years; patients with 25BMI30 kg/m2and HbA1c6%; patients with 25BMI30 kg/m2and HbA1c6%; patients with BMI30 kg/m2and HbA1c6% (+ Obesity - T2D) obese patients without T2D or prediabetes; patients with BMI30 kg/m2and newly-diagnosed T2D/prediabetes, HbA1c6%; patients with known history of T2D on glucose-lowering drugs with BMI30 kg/m2. Insulin, GLP-1, GIP were measured during glucose-tolerance test at 0, 30 and 120 minutes; insulin resistance (IR) was assessed by HOMA-IR. Results.Waist circumference was bigger in patients with obesity despite their metabolic profile comparing to patients without obesity (p0.001). Waist-to-hip ratio was similar in patients with different metabolic status. According to IR + Obesity - T2D group had intermediate position: IR was higher in that group comparing to people without obesity, but was less that in patients with obesity and HbA1c6% (p0.001). + Obesity - T2D group had the most potent baseline insulin secretion, assessed by НОМА-%band the highest postprandial secretion, measured by insulinogenic index among all patient groups with obesity (p0.001). There was no significant difference in GLP-1 secretion; GIP secretion was higher in patients with BMI30 kg/m2comparing to people with BMI30 kg/m2(p0.01).

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Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study

Cited by 30 publications

References 9 publications

Evaluation of lipid disorders and hyperglycemia in an open population aged 30-69 years: results of a multicenter study

Evaluation of lipid disorders and hyperglycemia in an open population aged 30-69 years: results of a multicenter study

Clinical Classification of the Diabetic Foot Syndrome Adapted to ICD-10 as a Solution to the Problem of Diagnostics, Statistics and Standardisation

Obesity without diabetes: the role of hormonal regulation

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