Type 2 Diabetes and Risk of Hip Fractures and Non-Skeletal Fall Injuries in the Elderly: A Study From the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO)

Wallander, Märit; Axelsson, Kristian F; Nilsson, Anders; Lundh, Dan; Lorentzon, Mattias

doi:10.1002/jbmr.3002

Cited by 93 publications

(99 citation statements)

References 28 publications

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“…The 'Fractures and fall injuries in the elderly cohort' (FRAILCO, [13]) is a national cohort based on information from several Swedish national registers, linked in order to study associations regarding fractures, fall injuries, morbidity, mortality and medications. Patients were initially selected from the Senior Alert register, consisting of men and women ≥65 years, who underwent a fall risk assessment in connection to a visit to a healthcare facility in Sweden between 2008 and 2014 [14].…”

Section: Study Populationmentioning

confidence: 99%

Hip fracture risk and safety with alendronate treatment in the oldest‐old

et al. 2017

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Section: Study Populationmentioning

confidence: 99%

Hip fracture risk and safety with alendronate treatment in the oldest‐old

et al. 2017

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“…Some of this risk might be captured by insulin use. In a recent report ( N = 429,313) it was shown that T2D patients regardless of medical regimen are more likely to fall than nondiabetics, but hip fractures were only increased in insulin users (HR 1.24 (95% CI: 1.16 1.32)) . This suggests that a mechanism that affects bone strength (e.g., insulin use or diabetes complications) in addition to falls likely plays a role in the increased fracture risk.…”

Section: What Accounts For the Higher Fracture Risk In T1d And T2d?mentioning

confidence: 99%

Skeletal fragility in diabetes

Rubin

2017

Annals of the New York Academy of Sciences

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Fracture risk is heightened in patients with both type 1 diabetes (T1D) and type 2 diabetes (T2D). Although bone mineral density by dual-energy X-ray absorptiometry is decreased in T1D, it is paradoxically increased with T2D. To predict fracture risk, the Fracture Risk Assessment Tool (FRAX) can be used in diabetes patients, albeit with refinement. Skeletal abnormalities in diabetes include alterations in microarchitecture in T1D and T2D as well as compromised impact microindentation in T2D. Changes in bone microvasculature, advanced glycation end product accumulation, and bone formation may underlie these findings. When fractures occur in T1D and T2D, consequences are worse than in nondiabetic patients with regard to both morbidity and mortality. With regard to treatment, antiresorptive osteoporosis therapies appear to be effective in the setting of diabetes.

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“…It was revealed that the number of females (54.73%) was higher than the number of males (45.26%) among subjects with hip fracture. Thus, females had higher risk of hip fracture than males on comparing to the control group (Wallander et al) 13 Increased rate of hip fracture is in women which could be because of osteoporosis found commonly after attaining the menopausal age because of hormonal changes.…”

Section: Resultsmentioning

confidence: 99%

A Case Control Study on the Incidence and Prevalence of Hip Fracture in Association with Hypoglycemic Drugs Among Type II Diabetic Patients in a Major Trauma Care Center

Aishwarya¹,

Sunny²,

Biji³

et al. 2019

IJOPP

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Background: Type II DM is a common metabolic disorder with increasing prevalence throughout the world. There is growing evidence indicating the effects of medications for diabetes on bone metabolism and fracture risk. More research is required to know the overall impact of these medications on bone health. Aim: To determine the incidence and prevalence of hip fracture in association with hypoglycemic drugs among Type II DM patients in major trauma care center. Objectives: To evaluate and compare the incidence and prevalence of hip fracture, the effect of hypoglycemic drugs on bone metabolism and fracture risk as well as the future probability of hip fracture risk in diabetes patients taking hypoglycemic drugs. Methodology: A case-control study was conducted with a sample size of 250 patients which included 95 cases and 155 control subjects enrolled for a period of 6 months in a major trauma care center. Subjects were assessed for future hip fracture risk within 10 years using WHO FRAX Score. Odds ratio (OR) were calculated using Fisher's Exact Test and statistical testing was performed at 0.05% level of significance with 95% CI. Results: Type II DM patients taking hypoglycemic drugs were associated with increased risk of hip fracture (odds ratio [OR] =2.97). Incidence (19.2%) and prevalence (60%) of hip fractures was higher in patients taking hypoglycemic drugs than the incidence (14.8%) and prevalence (40%) of those who were not taking the drug. Conclusion: Hip fracture incidence in Type II DM patients taking hypoglycemic drug is higher than the patients who were not taking the drugs. FRAX tool has been proved to be helpful in preventing future incidents.

show abstract

Type 2 Diabetes and Risk of Hip Fractures and Non-Skeletal Fall Injuries in the Elderly: A Study From the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO)

Cited by 93 publications

References 28 publications

Hip fracture risk and safety with alendronate treatment in the oldest‐old

Hip fracture risk and safety with alendronate treatment in the oldest‐old

Skeletal fragility in diabetes

A Case Control Study on the Incidence and Prevalence of Hip Fracture in Association with Hypoglycemic Drugs Among Type II Diabetic Patients in a Major Trauma Care Center

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