Type 2 Diabetes in Patients With Major Depressive Disorder: A Meta-Analysis of Prevalence Estimates and Predictors

Vancampfort, Davy; Mitchell, Alex J.; Hert, Marc De; Sienaert, Pascal; Probst, Michel; Buys, Roselien; Stubbs, Brendon

doi:10.1002/da.22387

Cited by 156 publications

(113 citation statements)

References 79 publications

(135 reference statements)

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“…Antipsychotic use, smoking and sedentary lifestyle have been suggested to be the main contributors to the increased risk of cardiometabolic diseases in schizophrenia [5, 43–45]. More recently, there has been increasing concern about the poor dietary intake and, in particular, excess consumption of saturated fats, sugar, and low fiber intake, which can increase the risk of cardiometabolic disease [46].…”

Section: Discussionmentioning

confidence: 99%

Physical multimorbidity and psychosis: comprehensive cross sectional analysis including 242,952 people across 48 low- and middle-income countries

Stubbs

Koyanagi

Veronese

et al. 2016

BMC Med

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137

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BackgroundIn people with psychosis, physical comorbidities, including cardiovascular and metabolic diseases, are highly prevalent and leading contributors to the premature mortality encountered. However, little is known about physical health multimorbidity in this population or in people with subclinical psychosis and in low- and middle-income countries (LMICs). This study explores physical health multimorbidity patterns among people with psychosis or subclinical psychosis.MethodsOverall, data from 242,952 individuals from 48 LMICs, recruited via the World Health Survey, were included in this cross-sectional study. Participants were subdivided into those (1) with a lifetime diagnosis of psychosis (“psychosis”); (2) with more than one psychotic symptom in the past 12 months, but no lifetime diagnosis of psychosis (“subclinical psychosis”); and (3) without psychotic symptoms in the past 12 months or a lifetime diagnosis of psychosis (“controls”). Nine operationalized somatic disorders were examined: arthritis, angina pectoris, asthma, diabetes, chronic back pain, visual impairment, hearing problems, edentulism, and tuberculosis. The association between psychosis and multimorbidity was assessed by multivariable logistic regression analysis.ResultsThe prevalence of multimorbidity (i.e., two or more physical health conditions) was: controls = 11.4% (95% CI, 11.0–11.8%); subclinical psychosis = 21.8% (95% CI, 20.6–23.0%), and psychosis = 36.0% (95% CI, 32.1–40.2%) (P < 0.0001). After adjustment for age, sex, education, country-wise wealth, and country, subclinical psychosis and psychosis were associated with 2.20 (95% CI, 2.02–2.39) and 4.05 (95% CI, 3.25–5.04) times higher odds for multimorbidity. Moreover, multimorbidity was increased in subclinical and established psychosis in all age ranges (18–44, 45–64, ≥ 65 years). However, multimorbidity was most evident in younger age groups, with people aged 18–44 years with psychosis at greatest odds of physical health multimorbidity (OR = 4.68; 95% CI, 3.46–6.32).ConclusionsThis large multinational study demonstrates that physical health multimorbidity is increased across the psychosis-spectrum. Most notably, the association between multimorbidity and psychosis was stronger among younger adults, thus adding further impetus to the calls for the early intervention efforts to prevent the burden of physical health comorbidity at later stages. Urgent public health interventions are necessary not only for those with a psychosis diagnosis, but also for subclinical psychosis to address this considerable public health problem.

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Section: Discussionmentioning

confidence: 99%

Physical multimorbidity and psychosis: comprehensive cross sectional analysis including 242,952 people across 48 low- and middle-income countries

Stubbs

Koyanagi

Veronese

et al. 2016

BMC Med

Self Cite

137

130

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“…1 The presence of depression is significantly associated with disability, reduced quality of life, increased mortality and higher cardiovascular disease risk. [2][3][4] The prevention of depression is of critical importance and the development of objective predictors of future depression is essential in order to identify early those who may be at risk.…”

Section: Introductionmentioning

confidence: 99%

Poor Physical Performance Predicts Future Onset of Depression in Elderly People: Progetto Veneto Anziani Longitudinal Study

Veronese

Stubbs

Trevisan³

et al. 2017

Physical Therapy

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“…This is exemplified by a recent U.K. study of 450 participants with SMI who were using mental health services in which researchers found that nearly all women and most men had a waist circumference exceeding the International Diabetes Federation (IDF) threshold for central obesity, with the half of the sample being obese, one-fifth meeting the criteria for type 2 diabetes mellitus (T2DM) and 57 % meeting the IDF criteria for MetS [5]. Moreover, people with schizophrenia [6], bipolar disorder [7] and major depressive disorder [8] are at significantly increased risk of T2DM. Much of the increase in CVD and MetS appears to be related to anti-psychotic medication and unhealthy lifestyle factors [9].…”

Section: Introductionmentioning

confidence: 99%

‘Walk This Way’ – a pilot of a health coaching intervention to reduce sedentary behaviour and increase low intensity exercise in people with serious mental illness: study protocol for a randomised controlled trial

Williams

Stubbs

Gaughran

et al. 2016

Trials

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BackgroundPeople with serious mental illness (SMI) (psychosis, bipolar disorder and major depressive disorder) experience a considerable risk of premature mortality because of cardiovascular disease. Recent research has demonstrated that this population spends almost 13 h per day being sedentary. Sedentary behaviour is an independent risk factor for cardiovascular disease and mortality. Given the potential for physical activity to improve health and well-being in people with SMI, we developed a pilot randomised controlled trial (RCT) to evaluate a coaching intervention aimed at reducing sedentary behaviour and increasing physical activity in people with SMI. Our primary aim was to assess the acceptability and feasibility of the intervention. Secondary aims were to see if the Walk This Way (WTW) intervention decreased sedentary behaviour and increased activity levels.Methods/designPeople with SMI who met any of the following criteria were recruited by two community mental health teams in South London: (1) overweight, (2) at risk for or have diabetes, (3) smoke tobacco or (4) have a sedentary lifestyle. Care co-coordinators (clinical case managers) identified potentially eligible participants within their caseload, and these individuals were subsequently invited to participate. All participants’ physical activity (self-reported and accelerometer-recorded), health status (including metabolic blood tests) and motivation to exercise were assessed at baseline. Participants were randomised to receive treatment as usual or the WTW intervention. WTW consisted of an educational intervention at baseline on the benefits of an active lifestyle. Participants were then given a pedometer and received fortnightly coaching from a staff member trained in coaching skills to help them to set daily walking targets, and they were invited to a weekly walking group. The WTW intervention lasted 17 weeks in total.DiscussionTo our knowledge, WTW is the first RCT to investigate the impact of a health coaching intervention targeting sedentary behaviour in people with SMI. It is hoped that if the intervention is feasible and acceptable, further large scale study can be developed and implemented in routine care.Trial registration ISRCTN37724980. Registered on 4 Aug 2015.

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Type 2 Diabetes in Patients With Major Depressive Disorder: A Meta-Analysis of Prevalence Estimates and Predictors

Abstract: T2DM is significantly more common in people with MDD compared with the general population. The current meta-analysis indicates that action is needed in order to curb the diabetes epidemic in this high-risk population.

Cited by 156 publications

References 79 publications

Physical multimorbidity and psychosis: comprehensive cross sectional analysis including 242,952 people across 48 low- and middle-income countries

Physical multimorbidity and psychosis: comprehensive cross sectional analysis including 242,952 people across 48 low- and middle-income countries

Poor Physical Performance Predicts Future Onset of Depression in Elderly People: Progetto Veneto Anziani Longitudinal Study

‘Walk This Way’ – a pilot of a health coaching intervention to reduce sedentary behaviour and increase low intensity exercise in people with serious mental illness: study protocol for a randomised controlled trial

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