2023
DOI: 10.1371/journal.pone.0288318
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Type 2 diabetes linked FTO gene variant rs8050136 is significantly associated with gravidity in gestational diabetes in a sample of Bangladeshi women: Meta-analysis and case-control study

U. S. Mahzabin Amin,
Tahia Anan Rahman,
Mashfiqul Hasan
et al.

Abstract: Objective Gestational diabetes mellitus (GDM) is a growing public health concern that has not been extensively studied. Numerous studies have indicated that a variant (rs8050136) of the fat mass-associated gene, FTO, is associated with both GDM and Type 2 diabetes mellitus(T2DM). We conducted a meta-analysis on the association between the FTO single nucleotide polymorphism (SNP) rs8050136 and T2DM, followed by a case-control study on the association of the said SNP and GDM in a sample of Bangladeshi women. M… Show more

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Cited by 2 publications
(2 citation statements)
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“…Although the FTO SNPs rs8050136, rs9939609, and rs1421085 did not emerge as major genetic regulators in the development of GDM, these SNPs were found to be associated with concentrations of adiponectin and TNFα in subjects with GDM [63]. SNP rs8050136 showed no significant association with GDM, but posed an increased risk of GDM in Bangladeshi multigravida women [67]. Interestingly, FTO SNPs are located in intron 1 (as listed in Table 1), suggesting a potential role in regulating the expression of FTO itself and possibly influencing nearby genes [58].…”
Section: Ftomentioning
confidence: 88%
See 1 more Smart Citation
“…Although the FTO SNPs rs8050136, rs9939609, and rs1421085 did not emerge as major genetic regulators in the development of GDM, these SNPs were found to be associated with concentrations of adiponectin and TNFα in subjects with GDM [63]. SNP rs8050136 showed no significant association with GDM, but posed an increased risk of GDM in Bangladeshi multigravida women [67]. Interestingly, FTO SNPs are located in intron 1 (as listed in Table 1), suggesting a potential role in regulating the expression of FTO itself and possibly influencing nearby genes [58].…”
Section: Ftomentioning
confidence: 88%
“…Individuals carrying the AT genotype of rs9939609 were found to have a higher risk of exceeding excessive gestational weight gain earlier than those with the TT genotype [62]. Notably, multiple meta-analysis studies have reported an inability to detect significant associations between FTO polymorphisms, including rs9939609, rs8050136, rs1421085, and rs1121980, and the risk of developing GDM [63][64][65][66][67].…”
Section: Ftomentioning
confidence: 99%