Type 2 Diabetes Mellitus and Coronary Heart Disease

Бардымова, Т. П.; Bardymova, Tatyana; Протасов, К. В.; Tsyretorova, Seseg; Донирова, Оюна; Донирова, О. С.

doi:10.12737/article_5955e6b60d5bf2.66416553

Acta Biomedica Scientifica

2017

DOI: 10.12737/article_5955e6b60d5bf2.66416553

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Type 2 Diabetes Mellitus and Coronary Heart Disease

Т. П. Бардымова¹,

Tatyana Bardymova

К. В. Протасов³

et al.

Abstract: САХАРНЫЙ ДИАБЕТ 2-ГО ТИПА И ИШЕМИЧЕСКАЯ БОЛЕЗНЬ СЕРДЦА 1 Иркутская государственная медицинская академия последипломного образования-филиал ФГБОУ «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Иркутск, Россия 2 ГАУЗ «Республиканская клиническая больница им. Н.А. Семашко» Министерства здравоохранения Республики Бурятия, Улан-Удэ, Россия Сахарный диабет приобретает масштабы эпидемии. Наблюдается рост числа больных ишемической болезнью сердца, страдающих сахарным диа… Show more

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Relationship of FoxP3+ T-lymphocyte subpopulations with metabolic parameters in patients with coronary heart disease and type 2 diabetes mellitus

Sirotina

Кологривова

2020

SMJ

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The aim of the present study was to assess the relationships between subpopulations of FoxP3+ T-lymphocytes (Treg) and metabolic parameters of peripheral blood in patients with coronary heart disease (CHD), depending on the presence of diabetes mellitus (DM) type 2.Material and Methods. The study material was mononuclear peripheral blood leukocytes. FoxP3+ Treg numbers and nuclear translocation of FoxP3 were evaluated by imaging flow cytometry.Results and Discussion. An inverse relationships was revealed (r = –0.900; p = 0.037) between the level of LDL cholesterol (low density lipoprotein cholesterol) and the level of FoxP3 translocation in CD4+CD25hiFoxP3+ and CD4+CD25loFoxP3+ lymphocytes in patients with diabetes. In patients without diabetes, a direct relationship was found between the level of FoxP3 nuclear translocation in CD4+CD25loFoxP3+ lymphocytes with high non-HDL cholesterol (total cholesterol without HDL cholesterol) (r = 0.900; p = 0.037). A direct correlation was also observed between the glucose concentration and the number of CD4+CD25loFoxP3 + lymphocytes (r = 0.900; p = 0.037).Conclusion. The level of transcription factor FoxP3 nuclear translocation correlated with the content of LDL cholesterol in patients with coronary artery disease in the presence of type 2 diabetes mellitus. The orientation of bonds was different for the conventional and regulatory subpopulations of T-lymphocytes. The metabolic parameters correlated with the level of transcription factor FoxP3 translocation exclusively in conventional T cells in patients with coronary artery disease in the absence of type 2 diabetes mellitus.

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Relationship of FoxP3+ T-lymphocyte subpopulations with metabolic parameters in patients with coronary heart disease and type 2 diabetes mellitus

Sirotina

Кологривова

2020

SMJ

View full text Add to dashboard Cite

show abstract

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Type 2 Diabetes Mellitus and Coronary Heart Disease

Cited by 1 publication

References 29 publications

Relationship of FoxP3+ T-lymphocyte subpopulations with metabolic parameters in patients with coronary heart disease and type 2 diabetes mellitus

Relationship of FoxP3+ T-lymphocyte subpopulations with metabolic parameters in patients with coronary heart disease and type 2 diabetes mellitus

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