Type 2 Diabetes Mellitus and the Risk of Hepatitis C Virus Infection: A systematic review

Guo, Xuan; Jin, Min; Yang, Ming; Liu, Ke; Lǐ, Jùnwén

doi:10.1038/srep02981

Cited by 58 publications

(60 citation statements)

References 52 publications

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“…Similar results were reported in a case-control study, 12.6 % patients with non-cirrhotic HCV had T2DM and the prevalence of T2DM was significantly higher than in non-cirrhotic HBV patients (4.9 %) [9]. Besides, patients with T2DM had a higher risk of HCV infection compared with non-T2DM patients [10].…”

Section: Introductionsupporting

confidence: 85%

Dual Infection with Hepatitis B Virus and Hepatitis C Virus Correlated with Type 2 Diabetes Mellitus

Lin

Chen

Lo³

et al. 2019

Exp Clin Endocrinol Diabetes

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Background Conflicting data exist regarding the relationship between dual infection of hepatitis B virus (HBV) and hepatitis C virus (HCV) with type 2 diabetes mellitus (T2DM). We assessed dual infection of HBV and HCV with the levels of blood glucose and development of DM. Methods A total of 9621 participants in a community-based study were enrolled from 18 towns in Maoli county of Taiwan. Blood samples were collected and tested for hepatitis B surface antigen (HBsAg) and antibodies (HBsAb), antibodies against hepatitis C virus (anti-HCV) and fasting plasma glucose. DM was defined as fasting plasma glucose≥126 mg per 100 ml. Results Only 0.7% of total participants had HBV/HCV coinfection. The prevalence of HBV and HCV monoinfection were 9.9 and 5.7%, respectively. Adjusted blood glucose levels and development risk of T2DM (odds ratio [OR], 2.55; p<0.001) were significantly high among HBV/HCV coinfection group using multivariate linear regression adjusted for age, gender, education, race and BMI. Furthermore, using multivariate logistic regression models adjusted for covariates, HCV mono-and HBV/ HCV coinfection significantly increased on blood glucose levels. Conclusions Our study shows HBV/HCV coinfection was significantly correlated with blood glucose levels. A significant proportion (28%) of participants with HBV/HCV coinfection developed T2DM. Although the precise mechanisms of dual positive infection of HBV and HCV are unclear, there is increasing evidence that dual infection of HCV and HBV is strongly associated with the development of T2DM.

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Section: Introductionsupporting

confidence: 85%

Dual Infection with Hepatitis B Virus and Hepatitis C Virus Correlated with Type 2 Diabetes Mellitus

Lin

Chen

Lo³

et al. 2019

Exp Clin Endocrinol Diabetes

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“…Several researchers observed diabetes mellitus more frequently in patients with genotype 2a HCV (Mason, 1999) and advanced liver fibrosis (Papatheodoridis, 2006). At the same time, some authors have found that patients with diabetes mellitus are more susceptible to infection by hepatitis C virus (Guo, 2013). Other researchers suppose that HCV serves as a trigger in the development of type 1 diabetes in susceptible persons.…”

Section: Resultsmentioning

confidence: 99%

Extrahepatic manifestations in patients with chronic hepatitis C

Dudanova¹,

Marina²,

Pisareva³

et al. 2014

Journal of Biomedical Technologies

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The aim of the study was to determine extrahepatic manifestations (EHM) of chronic hepatitis C (CHC) in patients with genotype 1 and 3a infections. Materials and methods. We examined 83 patients with CHC: 42 (50.6%) with genotype 1, and 41 (49.4%) with genotype 3a; 49 (59.0%) were males, 34 (41.0%) were females; the mean ± SD age of patients was 39.3±12.3 (range: 17-72) years. Chronic hepatitis was diagnosed in 75 (90.4%) patients, and cirrhosisin 8 (9.6%). Clinical, laboratory, histological, biochemical and virological data (AbHCV, viral RNA) were obtained. Results. EHM were observed in 27 (32.5%) patients: in 18 (42.9%) with genotype 1 infection, and in 9 (21.9%) with genotype 3a infection. The following manifestations were diagnosed: arthralgia (14.5%), purpura (8.4%), glomerulonephritis (6.0%), thyroiditis (6.0%), type 2 diabetes mellitus (3.6%), non-Hodgkin lymphoma (1.2%), Raynoud's phenomenon (1.2%), psoriasis (1.2%), vitiligo (1.2%). Cryoglobulinemia was detected in 9 (10.8%) patients. On average, EHM were revealed 2 times more frequently in females (25.3%) than in males (7.2%). Conclusion. Extrahepatic manifestations in CHC were observed in 32.5% of patients, more frequently in patients infected with genotype 1 virus and in females, than in patients with genotype 3a infection and males.

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“…Another study of people enrolled in a community‐based cohort in the US showed that HCV infection increased the risk of developing diabetes [adjusted hazard ratio (HR), 11.6; 95% CI 1.4–96.6], but only among those at high risk of diabetes (based on body mass index and age) . Finally, a recent meta‐analysis suggested, on the basis of limited evidence, that having diabetes can also be a risk factor for contracting HCV .…”

Section: Introductionmentioning

confidence: 99%

“…6], but only among those at high risk of diabetes (based on body mass index and age) [11]. Finally, a recent meta-analysis suggested, on the basis of limited evidence, that having diabetes can also be a risk factor for contracting HCV [12].…”

Section: Introductionmentioning

confidence: 99%

Matched population‐based study examining the risk of type 2 diabetes in people with and without diagnosed hepatitis C virus infection

Schnier

Kurdi

Povey

et al. 2016

Journal of Viral Hepatitis

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Meta-analyses have found hepatitis C virus (HCV) infection to be associated with an increased risk of type 2 diabetes mellitus (T2DM). Here, we examine this association within a large population-based study, according to HCV RNA status. A data-linkage approach was used to examine the excess risk of diagnosed T2DM in people diagnosed with antibodies to HCV (anti-HCV) in Scotland (21 929 anti-HCV(+ves) ; involving 15 827 HCV RNA(+ves) , 3927 HCV RNA(-ves) and 2175 with unknown RNA-status) compared to that of a threefold larger general population sample matched for gender, age and postcode (65 074 anti-HCV(-ves) ). To investigate effects of ascertainment bias the following periods were studied: up to 1 year before (pre-HCV)/within 1 year of (peri-HCV)/more than 1 year post (post-HCV) the date of HCV-diagnosis. T2DM had been diagnosed in 2.9% of anti-HCV(+ves) (including 3.2% of HCV RNA(+ves) and 2.3% of HCV RNA(-ves) ) and 2.7% of anti-HCV(-ves) . A higher proportion of T2DM was diagnosed in the peri-HCV period (i.e. around the time of HCV-diagnosis) for the anti-HCV(+ves) (22%) compared to anti-HCV(-ves) (10%). In both the pre-HCV and post-HCV periods, only those anti-HCV(+ves) living in less deprived areas (13% of the cohort) were found to have a significant excess risk of T2DM compared to anti-HCV(-ves) (adjusted odds ratio in the pre-HCV period: 4.0 for females and 2.3 for males; adjusted hazard ratio in the post-HCV period: 1.5). These findings were similarly observed for both HCV RNA(+ves) (chronic) and HCV RNA(-ves) (resolved). In the largest study of T2DM among chronic HCV-infected individuals to date, there was no evidence to indicate that infection conveyed an appreciable excess risk of T2DM at the population level.

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Type 2 Diabetes Mellitus and the Risk of Hepatitis C Virus Infection: A systematic review

Cited by 58 publications

References 52 publications

Dual Infection with Hepatitis B Virus and Hepatitis C Virus Correlated with Type 2 Diabetes Mellitus

Dual Infection with Hepatitis B Virus and Hepatitis C Virus Correlated with Type 2 Diabetes Mellitus

Extrahepatic manifestations in patients with chronic hepatitis C

Matched population‐based study examining the risk of type 2 diabetes in people with and without diagnosed hepatitis C virus infection

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