Type 2 diabetes mellitus associated with increased risk for colorectal cancer: Evidence from an international ecological study and population-based risk analysis in China

Diabetes mellitus and incidence and mortality of colorectal cancer: a systematic review and meta-analysis of cohort studies

“…Thus, a total of 35 articles (41 cohort studies), which met the inclusion and exclusion criteria, were used in this meta-analysis (Tables 1, 2). The countries or continents in which the studies were conducted were: Asia (n = 5) [16,[31][32][33][34], the US (n = 16) [11-13, 15, 19, 25, 35-44], Europe (n = 12) [18,21,[45][46][47][48][49][50][51][52][53][54], Israel (n = 1) [20] and Asia Pacific region (n = 1) [17].…”

Diabetes Mellitus Is an Independent Risk Factor for Colorectal Cancer

“…The analysis indicated that diabetic subjects have a statistically significant increased risk of developing CRC [16]. Since the publication of that paper, nearly 20 studies [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] have been conducted to examine the relationship between DM and risk of CRC. Most recent studies have supported a positive association but were inconsistent regarding sex or cancer subsite [22,29,32].…”

Implications of Type II Diabetes Mellitus on Gastrointestinal Cancers

“…Adjusted for confounding factors such as age, BMI, alcohol, smoking, physical exercise, bowel movement, family history of CRC, family history of DM, vegetable intake and dietary restriction, past/present history of diabetes was associated with increased CRC risk for both men and women (OR=1.3, 95% CI 1.0-1.65, OR=1.13, 95% CI 0.72-1.76, respectively) (Kuriki et al, 2007). A more significant association between Type II DM and CRC was observed by Ren and colleagues in their population-based case-control study conducted in China (SIR = 1.82, 95% CI 1.23-2.4 in Type II DM men, SIR = 1.36, 95% CI 0.85-1.88 in Type II DM women) (Ren et al, 2009). Inoue and colleagues have observed moderately increased risk of colon CA in diabetic men (HR 1.36, 95% CI 1.0-1.85) and rectal CA in diabetic women (HR 1.65, 95% CI 0.8-3.39), without statistically significant increase of colon CA in diabetic women and rectal CA in diabetic men.…”

“…Conversely, in women, Type II DM was not a risk factor for overall, proximal or distal CRC (SIR = 1.03, 95% CI 0.60-1.66; SIR = 1.17, 95% CI 0.58-2.09; and SIR = 0.74, 95% CI 0.24-1.72, respectively) (Limburg et al, 2006) [ Table 1]. Large population-based case-control studies conducted by Ren et al in China, and by Kuriki et al and Inoue et al in Japan, established that association between Type II DM and CRC is statistically significant in both men and women; however, Type II DM women showed less pronounced risk for CRC compared to Type II men (Inoue et al, 2006;Kuriki et al, 2007: Ren et al, 2009). Kuriki and colleagues studied the associations between Type II DM and multi-site cancer risks in a case-control study of 11,672 cancer cases (5341 men, 6331 women) and 47,768 cancer-free controls.…”