Type 2 diabetes mellitus in obesity promotes prolongation of cardiomyocyte contractile function, impaired Ca2+ handling and protein carbonylation damage

Coelho, Priscila M.; Simmer, Luísa M.; da Silva, Daniel S.; dos Santos, Matheus C.; Kitagawa, Rodrigo R.; Pezzin, Mateus F.; Correa, Camila R.; Leite, Jéssica G.; Leopoldo, André S.; Lima-Leopoldo, Ana Paula

doi:10.1016/j.jdiacomp.2023.108559

Journal of Diabetes and its Complications

2023

DOI: 10.1016/j.jdiacomp.2023.108559

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Type 2 diabetes mellitus in obesity promotes prolongation of cardiomyocyte contractile function, impaired Ca2+ handling and protein carbonylation damage

Priscila M. Coelho,

Luísa M. Simmer,

Daniel S. da Silva

et al.

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2024

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Cited by 2 publications

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High‐intensity interval training improves cardiomyocyte contractile function and myofilament sensitivity to intracellular Ca²⁺ in obese rats

dos Santos,

da Silva,

Cordeiro

et al. 2024

Experimental Physiology

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High‐intensity interval training (HIIT) has shown significant results in addressing adiposity and risk factors associated with obesity. However, there are no studies that investigate the effects of HIIT on contractility and intracellular Ca2+ handling. The purpose of this study was to explore the impact of HIIT on cardiomyocyte contractile function and intracellular Ca2+ handling in rats in which obesity was induced by a saturated high‐fat diet (HFD). Male Wistar rats were initially randomized into a standard diet and a HFD group. The experimental protocol spanned 23 weeks, comprising the induction and maintenance of obesity (15 weeks) followed by HIIT treatment (8 weeks). Performance was assessed using the maximum oxygen consumption test (). Evaluation encompassed cardiac, adipose and skeletal muscle histology, as well as contractility and intracellular Ca2+ handling. HIIT resulted in a reduction in visceral area, an increase in , and an augmentation of gastrocnemius fibre diameter in obese subjects. Additionally, HIIT led to a decrease in collagen fraction, an increase in percentage shortening, and a reduction in systolic Ca2+/percentage shortening and systolic Ca2+/maximum shortening rates. HIIT induces physiological cardiac remodelling, enhancing the contractile function of cardiomyocytes and improving myofilament sensitivity to Ca2+ in the context of obesity. This approach not only enhances cardiorespiratory and physical performance but also reduces visceral area and prevents interstitial fibrosis.

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High‐intensity interval training improves cardiomyocyte contractile function and myofilament sensitivity to intracellular Ca²⁺ in obese rats

dos Santos,

da Silva,

Cordeiro

et al. 2024

Experimental Physiology

View full text Add to dashboard Cite

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To Explore the Influence of Sanshen Jiangxiao Capsule on TCM Symptom Score and Blood Sugar Level of Type 2 Diabetes Patients with Obesity

王

2024

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Type 2 diabetes mellitus in obesity promotes prolongation of cardiomyocyte contractile function, impaired Ca2+ handling and protein carbonylation damage

Cited by 2 publications

References 40 publications

High‐intensity interval training improves cardiomyocyte contractile function and myofilament sensitivity to intracellular Ca²⁺ in obese rats

High‐intensity interval training improves cardiomyocyte contractile function and myofilament sensitivity to intracellular Ca²⁺ in obese rats

To Explore the Influence of Sanshen Jiangxiao Capsule on TCM Symptom Score and Blood Sugar Level of Type 2 Diabetes Patients with Obesity

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Type 2 diabetes mellitus in obesity promotes prolongation of cardiomyocyte contractile function, impaired Ca2+ handling and protein carbonylation damage

Cited by 2 publications

References 40 publications

High‐intensity interval training improves cardiomyocyte contractile function and myofilament sensitivity to intracellular Ca2+ in obese rats

High‐intensity interval training improves cardiomyocyte contractile function and myofilament sensitivity to intracellular Ca2+ in obese rats

To Explore the Influence of Sanshen Jiangxiao Capsule on TCM Symptom Score and Blood Sugar Level of Type 2 Diabetes Patients with Obesity

Contact Info

Product

Resources

About

High‐intensity interval training improves cardiomyocyte contractile function and myofilament sensitivity to intracellular Ca²⁺ in obese rats

High‐intensity interval training improves cardiomyocyte contractile function and myofilament sensitivity to intracellular Ca²⁺ in obese rats