Type 2 diabetes mellitus (T2DM) subjects of Bangladeshi origin with fast N-acetyltransferase 2 (NAT2) acetylator phenotype show lower insulin sensitivity than slow acetylator phenotype

Tumour necrosis factor-α −308G/A polymorphism is associated with insulin secretory defects in Bangladeshi prediabetic/diabetic subjects

“…World Health Organization (WHO) guidelines (1999) were followed to identify IGT and T2D subjects. 19 The study participants submitted signed informed consent letters. Data were collected using a pretested standard questionnaire.…”

Single nucleotide polymorphisms in genes encoding xenobiotic metabolizing enzymes are associated with predisposition to arterial hypertension

“…Previous studies have already shown a positive association between air pollutants and insulin resistance in subjects with the GG genotype of the rapid acetylator phenotype rs1799930 NAT2 [37]. Another study also showed that T2DM patients with the rapid acetylator phenotype (carriers of the GG genotype) had significantly higher absolute insulin levels and lower insulin sensitivity compared with patients characterized by a slow acetylator phenotype [38].…”