2019
DOI: 10.14309/ajg.0000000000000450
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Type 2 Diabetes Prevention Diet and Hepatocellular Carcinoma Risk in US Men and Women

Abstract: OBJECTIVES: Adherence to a healthy diet has been associated with a reduced risk of type 2 diabetes (T2D). Hepatocellular carcinoma (HCC) may have overlapping mechanisms with T2D, such as inflammation and insulin resistance. Thus, we examined the association between a previously developed T2D prevention dietary pattern and HCC risk. METHODS: We followed 87,943 women in the Nurses' Health Study and 49,665 men in the Health Professionals Follow-up Study fo… Show more

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Cited by 41 publications
(35 citation statements)
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“…This is the first study in which the DRRD was examined in association with endometrial cancer. An inverse association of the DRRD with breast cancer [ 39 , 40 ], pancreatic cancer [ 41 ], and hepatocellular carcinoma [ 38 ] has previously been observed.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This is the first study in which the DRRD was examined in association with endometrial cancer. An inverse association of the DRRD with breast cancer [ 39 , 40 ], pancreatic cancer [ 41 ], and hepatocellular carcinoma [ 38 ] has previously been observed.…”
Section: Discussionmentioning
confidence: 99%
“…The original version of the DRRD was characterized by high intakes of cereal fiber, coffee and nuts, high polyunsaturated:saturated fats ratio, low glycemic index (GI), and low intakes of red and processed meat, sugar-sweetened beverages, and trans fats. Higher adherence to the original DRRD was found to decrease the risk of hepatocellular carcinoma [ 38 ]. More recently, a new version of the DRRD was developed, where fruit was added as a favorable component and fruit juices were included in the sugar-sweetened beverage unfavorable component.…”
Section: Introductionmentioning
confidence: 99%
“…2,4 In recent years, there are abundant evidences showing that diabetes mellitus (DM) is a confirmed risk factor for HCC and diabetic patients have a higher incidence of HCC. 5,6 According to the 8th IDF Atlas, 425 million people have suffered from diabetes in 2007 and the number will rise to 629 million by 2045. 7 Metformin (1,1-dimethylbiguanide hydrochloride), a biguanide derivative, is one of the most used first-line anti-hyperglycemic drugs for type 2 DM.…”
Section: Introductionmentioning
confidence: 99%
“… 14 Moreover, a greater adherence to a T2DM prevention diet is associated with a lower risk of developing HCC among US men and women. 15 …”
Section: Epidemiologymentioning
confidence: 99%