Type 2 Immunity Regulates Dermal White Adipose Tissue Function

Satzinger, Sabrina; Willenborg, Sebastian; Ding, Xiaolei; Klose, Christoph S. N.; Radtke, Daniel; Voehringer, David; Eming, Sabine A.

doi:10.1016/j.jid.2023.05.017

Journal of Investigative Dermatology

2023

DOI: 10.1016/j.jid.2023.05.017

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Type 2 Immunity Regulates Dermal White Adipose Tissue Function

Sabrina Satzinger¹,

Sebastian Willenborg²,

Xiaolei Ding³

et al.

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2024

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Cited by 2 publications

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Adipose Tissue, Regeneration, and Skin Health: The Next Regenerative Frontier

Widgerow

2024

Aesthetic Surgery Journal Open Forum

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Adipose tissue, fat compartments, through the years have been considered as storage depots and an energy source. However, a major amount of new research, starting with the discovery of adipose derived stem cells, has redirected this thinking toward the tremendous regenerative capacity that adipose tissue has when it is healthy. This has resulted in multiple technologies being explored with fat as a basis or with fat as a target aiming at the stimulation of new small hyperplastic adipose cells exuding adipokines and encouraging the proliferation of a whole host of progenitor cells that can have positive effects on many organ systems. One of these organ systems is skin and there is a direct correlation with various fat compartments and skin health. Dermal fat tissue, also known as dermal white adipose tissue (dWAT) is one such compartment that originates from dermal preadipocytes transdifferentiating into adipocytes and progenitor adipose cells under the right cues. This paper discusses these potential cues including injectable fillers, fat grafts, topical formulations and their capacity to impact on skin health through generation of healthy fat tissue. In addition, small molecules such as GLP-1 peptides and their impact on fat tissue is discussed. Adipose tissue is being recognized as the next regenerative frontier with exciting prospects ahead.

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Adipose Tissue, Regeneration, and Skin Health: The Next Regenerative Frontier

Widgerow

2024

Aesthetic Surgery Journal Open Forum

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Caloric restriction impacts skin barrier function and attenuates the development of hyperplasia skin disease

Tang,

Li,

Jin

et al. 2024

Front. Nutr.

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Caloric restriction (CR) stands out as one of the most potent interventions that prolong lifespan and mitigate age-associated diseases. Despite its well-established systemic effects, the impact of CR on skin physiological function remains poorly understood, and whether the intervention can alleviate the progression of inflammatory skin diseases remains uncertain. Here, we investigated the effects of CR on mouse skin barrier function and inflammatory response. Our results revealed that CR led to dramatic atrophy in the skin subcutaneous layer. The expression of barrier proteins and trans-epidermal water loss remain largely unchanged. Intriguingly, skin from CR mice exhibited reduced expression of inflammatory cytokines under steady conditions. In an imiquimod (IMQ)-induced mouse model of psoriasis, CR treatment attenuated the pathogenesis of psoriasis phenotypes, accompanied by a reduced activation of mTOR signaling in the psoriatic skin. Taken together, our findings shed light on the complex interplay between metabolic interventions and skin health, suggesting that CR has the potential to serve as a modulator of inflammatory responses in the skin.

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Type 2 Immunity Regulates Dermal White Adipose Tissue Function

Cited by 2 publications

References 63 publications

Adipose Tissue, Regeneration, and Skin Health: The Next Regenerative Frontier

Adipose Tissue, Regeneration, and Skin Health: The Next Regenerative Frontier

Caloric restriction impacts skin barrier function and attenuates the development of hyperplasia skin disease

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