Type 2 Minocycline-induced hyperpigmentation successfully treated with the novel 755 nm picosecond alexandrite laser - a case report

Sasaki, Kenji; Ohshiro, Toshio; Ohshiro, Takafumi; Sakio, Reiko; Fukazawa, Emi; Toriumi, Masahiro; Ebihara, Tamotsu

doi:10.5978/islsm.17-cr-03

Cited by 19 publications

(14 citation statements)

References 12 publications

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“…Although these reports cast an optimistic outlook on the expanded use of picosecond lasers, further evidence is required in order to draw reliable conclusions. That being said, it is worthwhile noting that some traditionally difficult conditions to treat, such as minocycline-induced hyperpigmentation and chronic venous stasis hyperpigmentation have shown promising response and the use of picosecond laser in these settings should be considered an alternative treatment option when other modalities have proven unsatisfactory [30][31][32][33][34][35][36][37][38][39][41][42][43][44][45]94].…”

Section: Other Non-melasma Pigmented Conditionsmentioning

confidence: 99%

A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations

et al. 2020

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Background and Objectives The use of picosecond laser in dermatology was originally focused on optimizing the removal of unwanted tattoos. Subsequent advances in this technology have broadened its clinical indications to include treatment of benign pigmented lesions, photodamage, melasma, and scar revision. In this systematic review, evidence‐based recommendations are developed for the use of picosecond laser in dermatology. Study Design/Materials and Methods A comprehensive search of the English language literature was performed up to and including November 2019. Relevant citations were individually evaluated, synthesized, and categorized based on the Level of Evidence. With the addition of the authors’ combined clinical experience, clinical recommendations were developed. Results After application of inclusion and exclusion criteria, a total of 77 unique studies were evaluated. Treatment of benign pigmented lesions was associated with level I–IV evidence; rejuvenation was associated with level II evidence; melasma was associated with level II evidence; scar revision was associated with level II–III evidence; tattoo removal was associated with level I evidence. Conclusion Picosecond laser is a safe and effective treatment modality for an increasing range of dermatologic indications. Further development of this technology is warranted. Lasers Surg. Med. © 2020 Wiley Periodicals, Inc.

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Section: Other Non-melasma Pigmented Conditionsmentioning

confidence: 99%

A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations

et al. 2020

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“…This may bring about an inflammatory response secondary to damage at the basal skin layer and superficial dermal blood vessels. 8 Melanocyte activity may be altered in the basal layer with excessive epidermal injury, resulting in subsequent dyspigmentation especially in the darker Asian skin phenotypes. 9 This gives rise to the need for a device with more optimal photoacoustic effects, particularly in this patient population.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Laser-Responsive Dermal Pigmentary Conditions in Type III-IV Asian Skin With a 755-nm Picosecond Pulse Duration Laser: A Retrospective Review of Its Efficacy and Safety

Koh

Tan

Chua

2020

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BACKGROUND Picosecond lasers have become very popular in the treatment of hyperpigmentation. OBJECTIVE Evaluating the efficacy and safety of picosecond 755-nm laser in treatment of nevi of Ota (NO) and Hori's nevi (HN) in Asians with Fitzpatrick skin Types III/IV. METHODS A retrospective review of patient records at the National Skin Center, Singapore, from 2015 to 2017. Three independent blinded dermatologists assessed pre-and-post treatment photographs using the physician's global assessment (PGA) score (0-clear, 1-almost clear, 2-mild, 3-moderate, and 4-severe). RESULTS There were 18 cases of NO and 11 cases of HN. Mean treatment sessions were 2.22 (NO; range 1–6) and 3.82 (HN; range 1–6). In the NO group, mean pre-and-post treatment PGA scores were 3.1 and 1.3, respectively (1.8 point change, p -value 0.0002), and average fluence used was 2.02 J/cm 2 (range: 1.02–2.38). In the HN group, mean pre-and-post treatment PGA scores were 2.6 and 1.1, respectively (1.5 point change, p -value 0.004), and average fluence was 2.08 J/cm 2 (range: 1.98–3.40). Eleven patients (37.9%) experienced postlaser erythema, and 1 (3.4%) patient developed transient postlaser hypopigmentation. No permanent hyper/hypopigmentation was seen. CONCLUSION The picosecond 755-nm laser is effective in the treatment of dermal pigmentary conditions in Asians with Fitzpatrick skin Types III/IV, with minimal risk of postlaser complications, and compared with the center's past experience with the Q-switched nanosecond 1064-nm laser, results in faster and more effective pigment clearance.

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“…In contrast to previous cases requiring multiple treatments,3, 4 our patient experienced immediate and sustained cosmetic improvement after only 1 treatment. Although successful treatment of minocycline-related pigmentation has also been reported with newer picosecond lasers,6, 7 these devices are more expensive and less accessible than the Qs alexandrite laser. Other reports have also described the treatment of minocycline-associated pigmentation with combination laser modalities 8 .…”

Section: Discussionmentioning

confidence: 99%

Insight into the mechanisms of type III minocycline-induced pigmentation removal: A case of repeated immediate pigment clearing with the Q-switched 755-nm alexandrite laser over a 13-year period

Loh

Goldberg

Falsey³

et al. 2019

JAAD Case Reports

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Type 2 Minocycline-induced hyperpigmentation successfully treated with the novel 755 nm picosecond alexandrite laser - a case report

Cited by 19 publications

References 12 publications

A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations

A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations

Treatment of Laser-Responsive Dermal Pigmentary Conditions in Type III-IV Asian Skin With a 755-nm Picosecond Pulse Duration Laser: A Retrospective Review of Its Efficacy and Safety

Insight into the mechanisms of type III minocycline-induced pigmentation removal: A case of repeated immediate pigment clearing with the Q-switched 755-nm alexandrite laser over a 13-year period

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