Type A botulinum toxin in the treatment of chronic facial pain associated with masticatory hyperactivity

Lindern, J.-J. von; Niederhagen, Bernd; Bergé, Stefaan; Appel, T.

doi:10.1016/s0278-2391(03)00153-8

Cited by 145 publications

(165 citation statements)

References 12 publications

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“…Over 90 % of patients receiving the BTX-A solution showed a decrease in facial pain; the overall average improvement for the group was a decrease of 3.2 points on the VAS scale versus a 0.4 point difference for the placebo group (P _ 0.01). Noticeably, the patients with the greatest pretreatment pain intensity had the largest decrease in pain [21].…”

Section: Botulinum Toxin For Temporomandibular Joint Disordermentioning

confidence: 97%

“…All patients were followed up for minimum of 25 months, with no relapse of the muscular hypertrophy. In a second larger study, von Linder [21] recruited 90 patients with chronic facial pain caused by hyperactivity of the masticatory muscles, parafunctional movement and hypermobility disorders. He excluded patients with poorly defined pain syndromes, arthrogenic TMD, nonspecific pain radiation patterns and pain lacking a reference muscle.…”

Section: Botulinum Toxin For Temporomandibular Joint Disordermentioning

confidence: 99%

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Botulinum Toxin in the Treatment of Muscle Specific Oro-Facial Pain: A Literature Review

Dutt¹,

Ramnani²,

Thakur³

et al. 2014

J. Maxillofac. Oral Surg.

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Facial pain associated with temporomandibular joint (TMJ) and surrounding structures has been a challenge to clinicians as far as diagnosis and management is concerned. Complexity of anatomical structures within a small area, function of teeth and surrounding periodontal ligament, action of muscles, pathologies, lack of diagnostic investigations, all these complicate specific diagnosis of TMJ disorders. Various classifications have been designed and studied to help diagnose and treat TMJ related disorders, of which the simplest one is pain from TMJ proper and surrounding muscles. Many treatment modalities to treat pain arising from muscles around TMJ like splints, mouth restriction exercises, injection of sclerosing agents etc. have been used with various degrees of success. Botulinum toxin has been shown to be effective in the treatment of oro-facial pain due to muscular disorders and the same is discussed in detail in this review literature.

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Section: Botulinum Toxin For Temporomandibular Joint Disordermentioning

confidence: 97%

Section: Botulinum Toxin For Temporomandibular Joint Disordermentioning

confidence: 99%

Botulinum Toxin in the Treatment of Muscle Specific Oro-Facial Pain: A Literature Review

Dutt¹,

Ramnani²,

Thakur³

et al. 2014

J. Maxillofac. Oral Surg.

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“…In general, TMD patients are adults, but TMD can occur also in childhood [8,10]. It is generally the result of the coexistence of at least few of the factors that preThe masticatory system (MS) is the morphofunctional complex of mutually interacting tissues and organs of the mouth and facial part of the skull, forming a functional unit controlled by the central nervous system involved in the act of chewing, initial digestion, swallowing, the formation of sounds, breathing and participating in the expression of emotions.…”

mentioning

confidence: 99%

“…The possibility of using botulinum toxin in medicine was demonstrated for the first time in 1981 by Alan Scott. Using local injections of botulinum toxin he selectively inactivated muscle spasticity in strabismus [2,8].…”

mentioning

confidence: 99%

Clinical Aspects of the Use of Botulinum Toxin Type A in the Treatment of Dysfunction of the Masticatory System

Bogucki¹,

Kownacka²

2016

Adv Clin Exp Med

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istic wear of the incisal and occlusal surfaces of the teeth, cervical lesions as well as periodontal damage and atrophy [3]. These pathological changes can be very extensive. The systemic and external symptoms of masticatory system disorders (MSD) also include headache, neck and back pain, earache, tinnitus and hearing disorders, hypertrophy of the masseter and temporal muscles (a so-called "square-shaped face"), soreness in the region of the attachment points of the masseter and temporal muscles and an increase in tension and pain in the muscles of the shoulder girdle.The symptom of temporomandibular disorder (TMD) that usually make patients seek medical help is pain, which can take the form of severe headaches, often confused with migraine headaches, and/or facial pain. In general, TMD patients are adults, but TMD can occur also in childhood [8,10]. It is generally the result of the coexistence of at least few of the factors that preThe masticatory system (MS) is the morphofunctional complex of mutually interacting tissues and organs of the mouth and facial part of the skull, forming a functional unit controlled by the central nervous system involved in the act of chewing, initial digestion, swallowing, the formation of sounds, breathing and participating in the expression of emotions. The individual components of this system interact with each other, creating a biological morphological-functional complex [1]. Dental articulation, the joints and chewing muscles are elements of the MS that are closely related both anatomically and topographically [2]. As a result of parafunctional activity, excessive and prolonged muscle tension can occur around the temporomandibular joint (TMJ), the suboccipital muscles, the cervical spine and, frequently, the shoulder girdle muscles. In addition, an overload of the TMJ is observed. The oral cavity of patients with an overloaded TMJ usually shows character- AbstractThe purpose of this work is to present a new, still experimental method of treating temporomandibular disorders (TMD) by injecting botulinum toxin Type A (TBX-A), using its effects not as a toxin but as a medication. The mechanism of TBX-A, indications and contraindications for its use, as well as possible side effects, are discussed. Temporomandibular disorders are of concern to approximately 70-80% of the population. The effect of botulinum toxin depends on blocking the release of acetylcholine from a presynaptic neuromuscular synapse and, in the autonomous system, blocking its release from post-ganglionic cholinergic neurons. In cases of long-term TMJ disorders, muscle activity increases and spastic contractions may even appear. TBX-A offers an opportunity for a normal social and family life for many patients suffering from masticatory system disorders (MSD), who have been isolated from the environment by pain. The study is based on a review of the literature and the authors' own experiences during several attempts to treat patients by this method. TBX-A is a safe medicine when the injection is performed by a w...

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“…Endobuccal examination was very difficult because of the lack of mouth opening, however, a lot of wear was observed which was due to an off-centre bruxism occurring both night and day. The patient had dysfunctional swallowing and her attempts at mouth opening caused the simultaneous contraction of both agonist and antagonist muscles [1]. The patient had been taking anti-depressants for several months because her condition prevented her from being able to easily express herself and made eating very difficult, both of which had significantly negatively affected her mood.…”

mentioning

confidence: 99%

Botulinum Toxin Type-A Treatment for Severe Trismus of Occlusal Origin

Batifol¹

2014

Anaplastology

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A 65 year-old woman was referred to our department with limited mouth opening that was both extreme and painful and was causing difficulties with all facial expressions and making eating impossible. The dentist informed us that the patient believed the cause to be 'iatrogenic and prosthetic'. We were informed that the patient had changed odontologist and dental prostheses several times over the past 4 years.

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Type A botulinum toxin in the treatment of chronic facial pain associated with masticatory hyperactivity

Cited by 145 publications

References 12 publications

Botulinum Toxin in the Treatment of Muscle Specific Oro-Facial Pain: A Literature Review

Botulinum Toxin in the Treatment of Muscle Specific Oro-Facial Pain: A Literature Review

Clinical Aspects of the Use of Botulinum Toxin Type A in the Treatment of Dysfunction of the Masticatory System

Botulinum Toxin Type-A Treatment for Severe Trismus of Occlusal Origin

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