Type C coping, alexithymia, and heart rate reactivity are associated independently and differentially with specific immune mechanisms linked to HIV progression

Temoshok, Lydia; Waldstein, Shari R.; Wald, Rebecca L.; Garzino-Demo, Alfredo; Synowski, Stephen J.; Sun, Lingling; Wiley, James

doi:10.1016/j.bbi.2008.02.003

Cited by 47 publications

(26 citation statements)

References 74 publications

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“…They found discrepancies among the studies but, in general, dispositional optimism, active coping, and spirituality were most associated with slower progression of HIV disease. In another study (Temoshok et al, 2008), Type C coping, a maladaptive dispositional coping style described as a lack of emotional receptive and expressive capabilities, and a related personality trait, alexithymia, defined as a dysfunction of cognitive processing and emotional awareness, were both positively associated with immune dysfunction in PLWH, but through different pathways. Blashill, Perry, and Safren (2011) reviewed literature from 2009-2011 on mental health, stress, and coping related to treatment retention, adherence, and health outcomes in PLWH, and found a paucity of successful interventions in a population known to have significant mental health comorbidities.…”

Section: The Transactional Model Of Stress and Copingmentioning

confidence: 96%

Integration of the Interaction Model of Client Health Behavior and Transactional Model of Stress and Coping as a Tool for Understanding Retention in HIV Care Across the Lifespan

Graham

2015

Journal of the Association of Nurses in AIDS Care

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Retaining people living with HIV (PLWH) in care over the lifespan is critical to quality and longevity of life. Individual health behavior decisions that affect care retention are complicated and multifactorial. Current health behavior theories are inadequate in isolation to guide retention in care research. Two existing models, Cox's Interaction Model of Client Health Behavior, and Lazarus and Folkman's Transactional Model of Stress and Coping have both guided research with PLWH, although not related to retention in care. Integration of these models may more comprehensively inform care retention research and practice across the lifespan as it incorporates not only intra- and inter-personal characteristics and relationships but also the stress and coping experiences inevitable when living with a chronic illness such as HIV.

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Section: The Transactional Model Of Stress and Copingmentioning

confidence: 96%

Integration of the Interaction Model of Client Health Behavior and Transactional Model of Stress and Coping as a Tool for Understanding Retention in HIV Care Across the Lifespan

Graham

2015

Journal of the Association of Nurses in AIDS Care

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“…Goodkin et al found that active coping was associated with higher NK cytotoxicity (103). Furthermore, Temoshok et al (104) found that Type C coping (related to the nonexpression of emotions) was associated with increased antigen-stimulated production of the proinflammatory cytokine interleukin-6.…”

Section: Potential Biological Mechanismsmentioning

confidence: 99%

Do Positive Psychosocial Factors Predict Disease Progression in HIV-1? A Review of the Evidence

Ironson

Hayward

2008

Psychosomatic Medicine

143

103

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Adding to a traditional stress perspective, behavioral medicine has been focusing increasingly on investigating the potential impact of positive psychosocial factors on disease course in HIV. Dispositional optimism, active coping, and spirituality show the most evidence for predicting slower disease progression, although the data are not entirely consistent. Findings for the role of social support are mixed, although indications are that it may be particularly helpful at later stages of illness. Many of the other constructs (positive affect, finding meaning, emotional expression/processing, openness, extraversion, conscientiousness, altruism, and self-efficacy) have only been examined in one or two studies; results are preliminary but suggestive of protective effects. Plausible behavioral and biological mechanisms are discussed (including health behaviors, neurohormones, and immune measures) as well as suggestions for clinicians, limitations, future directions, and a discussion of whether these constructs can be changed. In conclusion, investigating the importance and usefulness of positive psychosocial factors in predicting disease progression in HIV is in its beginning scientific stages and shows good initial evidence and future promise.

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“…T cell counts appeared to be low in subjects classified as repressors of negative affect [20] , an alexithymia-related personality characteristic. Alexithymia has been associated with lower stimulated production of the anti-HIV ␤ -chemokine MIP-1 ␣ , suggesting a poorer prognosis [21] . An association with a shift toward Th2 immunity found initial support by the disclosure of a positive correlation between serum levels of IL-4 and alexithymia in 17 healthy women [22] .…”

Section: The Relationship Between Alexithymia and Circulating Cytokinmentioning

confidence: 99%

The Relationship between Alexithymia and Circulating Cytokine Levels in Subjects Undergoing Upper Endoscopy

Mandarelli

Tarsitani

Ippoliti³

et al. 2010

Neuroimmunomodulation

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Objective: Despite emerging evidence suggesting a link between alexithymia and immune function, previous studies yielded contrasting results. The proposed link between alexithymia and immune function remains controversial as does the role, in this relationship, of anxiety, depression and subjective stress. The aim of the study is to investigate the possible association between alexithymia and circulating levels of cytokines in subjects awaiting an upper endoscopy, a stressful procedure, controlling for anxiety levels, depression and subjective stress. Methods: Participants were recruited from among consecutive patients referred for routine diagnostic upper endoscopy. All participants completed the Toronto Alexithymia Scale (TAS-20), the Hospital Anxiety and Depression Scale, and the Stress-related Vulnerability Scale. Serum levels of IL-1β, IL-4, IL-6, IL-10, TNF-α and IFN-γ were measured by ELISA. Results: Of the 90 subjects initially approached, 68 completed the study. The TAS-20 identified 22 alexithymic and 36 non-alexithymic patients. ELISA detected significantly lower IL-4 and IL-6 concentrations in alexithymic than in non-alexithymic patients. According to multiple linear regression analysis, alexithymia predicted low IL-4 and IL-6 levels in the sample overall, independently of stress, anxiety, depression and other possible confounders. No between-group differences were found in serum levels of IFN-γ, IL-1β, and TNF-α. Conclusion: These findings argue against an isolated shift towards pro-inflammatory or anti-inflammatory mediators and suggest that circulating cytokine profiles differ in alexithymic and non-alexithymic subjects.

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Type C coping, alexithymia, and heart rate reactivity are associated independently and differentially with specific immune mechanisms linked to HIV progression

Cited by 47 publications

References 74 publications

Integration of the Interaction Model of Client Health Behavior and Transactional Model of Stress and Coping as a Tool for Understanding Retention in HIV Care Across the Lifespan

Integration of the Interaction Model of Client Health Behavior and Transactional Model of Stress and Coping as a Tool for Understanding Retention in HIV Care Across the Lifespan

Do Positive Psychosocial Factors Predict Disease Progression in HIV-1? A Review of the Evidence

The Relationship between Alexithymia and Circulating Cytokine Levels in Subjects Undergoing Upper Endoscopy

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