Type C viruses: Natural derivatives of cellular genes involved in malignant transformation

The infection of dog embryo kidney (DEK) cells with herpes simplex virus type 2 (HSV-2) or human cytomegalovirus (HCMV) led to the development of transformed cell lines. Rapidly dividing DEK cells with unlimited division potential exhibited growth in 2% serum, contained nuclear virus antigens, and formed small (+/- 0.2 mm) colonies in 0.3% agarose. Immortal cell lines showing the same transformation properties were also obtained after transfection with purified HSV-2 or HCMV DNA. These results confirm the transforming capacity of both herpesviruses as well as the usefulness of this different type of mammalian cells in transformation studies.

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Type C viruses: Natural derivatives of cellular genes involved in malignant transformation

Cited by 2 publications

References 94 publications

Human leukemia viruses? RNA tumor viruses, human malignancies, and concepts of viral carcinogenesis

Human leukemia viruses? RNA tumor viruses, human malignancies, and concepts of viral carcinogenesis

Transformation of dog embryo kidney cells by human herpesviruses

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