Type I interferon (IFN-α/β) rescues B-lymphocytes from apoptosis via PI3Kδ/Akt, Rho-A, NFκB and Bcl-2/BclXL

Badr, Gamal; Saad, Heba; Waly, Hanan; Hassan, Khadega; Abdel-Tawab, Hanem S.; Alhazza, Ibrahim M.; Ahmed, Emad A.

doi:10.1016/j.cellimm.2010.02.012

Cited by 49 publications

(30 citation statements)

References 38 publications

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“…The ECL signal was specifically recorded on ECL hyper-film. To quantify the band intensities, the films were scanned, saved as TIFF files, and analyzed using NIH ImageJ software [34, 35]. …”

Section: Methodsmentioning

confidence: 99%

Camel Whey Protein Protects B and T Cells from Apoptosis by Suppressing Activating Transcription Factor-3 (ATF-3)-Mediated Oxidative Stress and Enhancing Phosphorylation of AKT and IκB-α in Type I Diabetic Mice

Badr

Sayed

Omar

et al. 2017

Cell Physiol Biochem

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Background: Diabetes mellitus (DM) is associated with severe immune system complications. Camel whey protein (CWP) decreases free radicals (ROS) and modulates immune functions, but its effect on DM-impaired immune systems has not been studied. We investigated the impact of CWP on the immune system in a Type 1 diabetes mouse model. Methods: Three experimental groups were used: (1) non-diabetic control; (2) diabetic; and (3) CWP-treated diabetic mice. Results: Induction of diabetes by streptozotocin was associated with reduction of body weight and insulin level, increase in glucose level and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α), and reduction in IL-2 and IL-4 levels. Upregulated ATF-3 expression was followed by a marked elevation in ROS levels. Lymphocytes from diabetic mice exhibited increased apoptosis through decreased phosphorylation of AKT and IκB-α, increased infiltration of T cells in the spleen and thymus, and decreased B cell numbers in the spleen. Supplementation with CWP decreased the levels of proinflammatory cytokines, ROS, and ATF-3 expression, and increased the levels of IL-4. Treatment with CWP decreased apoptosis by enhancing the phosphorylation of AKT and IκB-α as well as T-cell and B-cell distribution in the spleen and thymus. Conclusions: Our findings suggest the beneficial effects of CWP supplementation during diabetes on decreasing and orchestrating the redox status and subsequently rescuing the immune cells from exhaustion.

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Section: Methodsmentioning

confidence: 99%

Camel Whey Protein Protects B and T Cells from Apoptosis by Suppressing Activating Transcription Factor-3 (ATF-3)-Mediated Oxidative Stress and Enhancing Phosphorylation of AKT and IκB-α in Type I Diabetic Mice

Badr

Sayed

Omar

et al. 2017

Cell Physiol Biochem

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“…Outcomes of IFN-I signaling may be as diverse as promotion of cell survival and promotion or prevention of apoptosis (29)(30)(31). Although all IFN-I ligands signal through the same receptor (IFNAR), they result in different biological outcomes (32).…”

Section: Ifn-i Effects On Target Cellsmentioning

confidence: 99%

Type I interferon–mediated autoimmune diseases: pathogenesis, diagnosis and targeted therapy

2017

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“…These data suggest that IFN-alpha plays an important role in the SLE-like syndrome occurring in MRL/lpr mice, and link aberrant apoptosis caused by FasL to high levels of IFN-I. It has been found that type 1 IFNs protect human B cells in culture from spontaneous apoptosis and from apoptosis mediated by anti-CD95 agonist, in a dose-and timedependant manner (Badr et al, 2010). Such effect on human B cells was totally abrogated by blockade of IFNR1 chain.…”

Section: Type I Interferons and Apoptosismentioning

confidence: 81%

Fas Pathway of Cell Death and B Cell Dysregulation in SLE

Paganelli¹,

Paganelli²,

Turi³

2012

Systemic Lupus Erythematosus

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Type I interferon (IFN-α/β) rescues B-lymphocytes from apoptosis via PI3Kδ/Akt, Rho-A, NFκB and Bcl-2/BclXL

Cited by 49 publications

References 38 publications

Camel Whey Protein Protects B and T Cells from Apoptosis by Suppressing Activating Transcription Factor-3 (ATF-3)-Mediated Oxidative Stress and Enhancing Phosphorylation of AKT and IκB-α in Type I Diabetic Mice

Camel Whey Protein Protects B and T Cells from Apoptosis by Suppressing Activating Transcription Factor-3 (ATF-3)-Mediated Oxidative Stress and Enhancing Phosphorylation of AKT and IκB-α in Type I Diabetic Mice

Type I interferon–mediated autoimmune diseases: pathogenesis, diagnosis and targeted therapy

Fas Pathway of Cell Death and B Cell Dysregulation in SLE

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