Type I retinopathy of prematurity in infants with birth weight less than 1251 g: Incidence and risk factors for its development in a nursery in Kuwait

Abstract

Purpose:To report the rate of acute retinopathy of prematurity (ROP) and Type I ROP among infants with birth weight (BW) <1251 g and identify the risk factors for the development of Type I ROP.Materials and Methods:A retrospective review of ROP records of infants with BW <1251 g was performed to identify infants with acute ROP and Type I ROP. Infants with Type I ROP were compared with those without Type I ROP to assess the risk factors for the development of Type I ROP. P < 0.05 was statistically significant. Multivariate analysis was performed and odds ratio (OR) and 95% confidence intervals (CI) were calculated.Results:Among the 207 infants with BW <1251 g, acute ROP occurred in 154 infants (74.4%) and Type I ROP in 95 eyes of 50 infants (24.4%). The numbers of infants with BW <750 g and BW <1000 g were 19.3% and 58.4%, respectively, and the incidences of Type I ROP were 50% and 36.4%, respectively, among them. Forty-four (46.3%) eyes were treated at stage 2+ ROP in zone I or II. All the eyes treated for Type I ROP showed complete regression. Gestational age at birth (OR 0.657, 95% CI: 0.521-0.827; P < 0.0001) and number of ventilated days (OR 1.017, 95% CI: 1.005-1.029; P = 0.006) were identified as independent risk factors for the development of Type I ROP.Conclusions:The rate of Type I ROP in this study is higher than that in previous studies due to the higher number of infants with BW <1000 g in our cohort and the treatment of more eyes with stage 2+ ROP. However, all the treated eyes had a favorable outcome. Gestational age at birth and number of ventilated days were independent risk factors for the development of Type I ROP.

The Incidence and Risk Factors of Severe Retinopathy of Prematurity in Extremely Low Birth Weight Infants in Turkey

“…The incidence of type 1 ROP in ELBW infants was reported as 36.4% by Gharaibeh et al [29] and Wani et al [30], which is similar to the rate in the present study. Choo et al reported that 32.9% of ELBW infants reached a stage of ROP requiring laser treatment [24].…”

“…The rate of type 1 ROP requiring laser treatment among 235 ELBW infants in the present study was 36.6%; only 1 study (by Hiraoka et al) reported a higher percentage of ELBW infants with severe ROP requiring laser treatment (41%) [ 28 ]. The incidence of type 1 ROP in ELBW infants was reported as 36.4% by Gharaibeh et al [ 29 ] and Wani et al [ 30 ], which is similar to the rate in the present study. Choo et al reported that 32.9% of ELBW infants reached a stage of ROP requiring laser treatment [ 24 ].…”

Mortality and Morbidity Patterns of Very Low Birth Weight Newborns in Eastern Mediterranean Region: A Meta-Analysis Study

“…In the current study, prevalence of various comorbidities with VLBW or VP in neonates was also analyzed. Table 3 summarizes the results (15,16,18,(20)(21)(22)(23)(24)(25)(26). The most prevalent comorbidity in VLBW newborns allocated to sepsis (49.0%; 95%CI: 38.0-59.0) (15) and the least belonged to PVL (3.0%; 95%CI:2.0-5.0) (16,18,20).…”

Long-Term Neurodevelopmental Outcome s After Preterm Birth

“…ROP remains as one of the causes of preventable childhood blindness worldwide and its incidence varies among different countries ( 52 ). Severe retinopathy of prematurity requires more treatment in Asia and South America than in most Western countries ( 53 ).…”