Type II diabetes mellitus and obesity: Common links, existing therapeutics and future developments

Banerjee, Subhadeep; Talukdar, Indrani; Banerjee, Arnab; Gupta, Arnav; Balaji, Advait; Aduri, Raviprasad

doi:10.1007/s12038-019-9962-7

Cited by 16 publications

(13 citation statements)

References 75 publications

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“…Obesity and other metabolic syndrome-related diseases, including type 2 diabetes, cardiovascular disease, and hypertension, are dramatically increasing worldwide, contributing to significantly increased healthcare spending in every country [1]. Moreover, the high body mass index and adiposity characteristic of obesity can lead to other metabolic and physiological alterations, such as low-grade inflammation, oxidative stress, or premature aging [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the high body mass index and adiposity characteristic of obesity can lead to other metabolic and physiological alterations, such as low-grade inflammation, oxidative stress, or premature aging [2,3]. In recent years, efforts have been made to develop different strategies to reduce excess adiposity in obese patients, but also to prevent the appearance and progression of other concomitant metabolic complications [1]. Thus, different groups have focused their efforts on the identification of bioactive compounds found in different food ingredients whose incorporation in the diet might exert beneficial properties in terms of the prevention and/or treatment of these obesity-related disturbances [4].…”

Section: Introductionmentioning

confidence: 99%

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Grifola frondosa (Maitake) Extract Reduces Fat Accumulation and Improves Health Span in C. elegans through the DAF-16/FOXO and SKN-1/NRF2 Signalling Pathways

et al. 2021

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In recent years, food ingredients rich in bioactive compounds have emerged as candidates to prevent excess adiposity and other metabolic complications characteristic of obesity, such as low-grade inflammation and oxidative status. Among them, fungi have gained popularity for their high polysaccharide content and other bioactive components with beneficial activities. Here, we use the C. elegans model to investigate the potential activities of a Grifola frondosa extract (GE), together with the underlying mechanisms of action. Our study revealed that GE represents an important source of polysaccharides and phenolic compounds with in vitro antioxidant activity. Treatment with our GE extract, which was found to be nongenotoxic through a SOS/umu test, significantly reduced the fat content of C. elegans, decreased the production of intracellular ROS and aging–lipofuscin pigment, and increased the lifespan of nematodes. Gene expression and mutant analyses demonstrated that the in vivo anti-obesity and antioxidant activities of GE were mediated through the daf-2/daf-16 and skn-1/nrf-2 signalling pathways, respectively. Taken together, our results suggest that our GE extract could be considered a potential functional ingredient for the prevention of obesity-related disturbances.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Grifola frondosa (Maitake) Extract Reduces Fat Accumulation and Improves Health Span in C. elegans through the DAF-16/FOXO and SKN-1/NRF2 Signalling Pathways

et al. 2021

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“…Thus, it is important to develop glucose-lowering or glucose uptake-enhancing strategy in the prevention or treatment of T2DM. Several drugs including insulin, biguanide (metformin), thiazolidinediones, sulfonylurea, α-glucosidase inhibitors, dipeptidyl peptidase-4 inhibitors, and Gliflozin category have been used to control the blood glucose level but are associated with various side effects . Therefore, an increasing number of food-derived bioactive components including bioactive peptides have been explored for their potential use in the prevention or treatment of T2DM .…”

Section: Introductionmentioning

confidence: 99%

Peptide Analogues of VPP and IPP with Improved Glucose Uptake Activity in L6 Myotubes can be Released from Cereal Proteins

Liu

Zheng

Zhou

et al. 2021

J. Agric. Food Chem.

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VPP (Val–Pro–Pro) and IPP (Ile–Pro–Pro) are two famous antihypertensive peptides with possible benefits for type 2 diabetes mellitus (T2DM). The study was aimed to investigate the effect of peptide analogues of VPP and IPP on glucose uptake activity in L6 myotubes. The analogues were designed by replacing the N-terminal, middle, or C-terminal amino acid residues of VPP and IPP with one amino acid at a time from five amino acid groups (polar, nonpolar, basic, acidic, and aromatic amino acids). Among 26 tripeptides tested, IQP, IPQ, VPE, and VEP showed significantly higher glucose uptake activity than their parent peptides, and all were successfully released from rice proteins at the contents of 5415.82 ± 63.34, 1586.77 ± 14.94, 354.07 ± 6.56, and 596.10 ± 2.32 ng/mg dry basis, respectively, and quantified by liquid chromatography–mass spectrometry (MS)/MS using multiple reaction monitoring. All four peptides were shown to promote glucose uptake via the adenosine monophosphate-activated protein kinase pathway accompanied by glucose transporter type 4 (Glut4) translocation rather than the insulin signaling pathway.

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“…[ 1 ] Obesity is caused by improper fat generation and is a metabolic disease that seriously endangers health. [ 2 ] It increases the risk for developing multiple diseases, such as hypertension, diabetes, cardiovascular disease, [ 3 ] several types of cancers, [ 4 ] and poor mental health. [ 5 ] All of these affect quality of life and work efficiency and increase medical costs.…”

Section: Introductionmentioning

confidence: 99%

Etiology of serum vitamin B12 elevation 1 month after bariatric surgery

et al. 2021

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Few studies have reported an increase in vitamin B 12 (VitB 12 ) levels after bariatric surgery. This study reports the phenomenon and adverse reactions of serum VitB 12 elevation 1 month after surgery and explores the possible etiologies. Retrospective analysis was performed on VitB 12 data for 112 patients from January 2018 to October 2019. Then, 87 patients were included between November 2019 and August 2020. They were divided into 2 groups according to the level of VitB 12 after surgery, and the demographic and clinical data were analyzed. Then, LASSO regression model analysis and multiple logistic regression analysis were performed to explore the risk factors for VitB 12 elevation after surgery. Retrospective data showed that the VitB 12 level was significantly increased 1 month after surgery. Comparison of data between the 2 groups found that more patients also had diabetes in the nonelevated group. The postoperative folic acid and VitB 12 levels of the elevated group were significantly higher than those of the nonelevated group. More patients had concurrent constipation in the elevated group than in the nonelevated group. Two meaningful variables in LASSO regression analysis were incorporated into the multivariate logistic regression analysis, and constipation was found to be an independent risk factor for the increase in VitB 12 after surgery. Of the 199 patients in this study, 111 patients had elevated VitB 12 levels after surgery. Among them, 7 patients had peripheral nerve symptoms. Constipation is an independent risk factor for increased VitB 12 levels after surgery. High levels of VitB 12 may cause some peripheral nerve symptoms. Therefore, it is necessary to pay attention to patients with postoperative constipation, monitor their VitB 12 level as soon as possible, and take measures to improve constipation to avoid some adverse reactions caused by elevated VitB 12 levels.

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Type II diabetes mellitus and obesity: Common links, existing therapeutics and future developments

Cited by 16 publications

References 75 publications

Grifola frondosa (Maitake) Extract Reduces Fat Accumulation and Improves Health Span in C. elegans through the DAF-16/FOXO and SKN-1/NRF2 Signalling Pathways

Grifola frondosa (Maitake) Extract Reduces Fat Accumulation and Improves Health Span in C. elegans through the DAF-16/FOXO and SKN-1/NRF2 Signalling Pathways

Peptide Analogues of VPP and IPP with Improved Glucose Uptake Activity in L6 Myotubes can be Released from Cereal Proteins

Etiology of serum vitamin B12 elevation 1 month after bariatric surgery

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