Type IV allergy to amide‐type local anesthetics

Klein, Corinna; Gall, H.

doi:10.1111/j.1600-0536.1991.tb01772.x

Cited by 49 publications

(18 citation statements)

References 6 publications

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“…This decrease may be explained by the use of amide anesthetics (lidocaine, mepivacaine, bupivacaine, etc. ), which are less common sensitizers (30). Although we observed a decrease in positive reactions to benzocaine, our rate of benzocaine sensitization (B2%) remained higher compared with Sertoli and colleagues' and Shireen's studies, which found approximately 1.3% and 0.4%, respectively, of benzocaine positive reactions (15,31).…”

Section: Anestheticsmentioning

confidence: 40%

Long-term trend in patch test reactions: a 32-year statistical overview (1970–2002), part II

Tudela

MacPherson

Maibach

2008

Cutaneous and Ocular Toxicology

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Allergic contact dermatitis remains an important problem worldwide. The objective of this study was to analyze patch test positivity trends of the North American Contact Dermatitis Group. Publications from 1970 to 2002 were reviewed and re-analyzed. Statistical significance was determined with a Cochran-Armitage trend test. We observed a significant increase in positive reactions with carbamates, balsam of Peru, thimerosal, formaldehyde, imidazolidinyl urea, and methyldibromoglutaronitrile. The rates of positive reactions to Dimethylol dimethyl (DMDM) hydantoin, diazolidinyl urea, and methylchloroisothiazolone/methylisothiazolone remained unchanged. We showed a significant decrease in positive reactions for all other allergens. These data provide challenges in public health--for industry, government, and medicine--to decrease the frequency of allergic contact dermatitis. However, the complexities of evaluating a 32-year analysis are numerous, so the data should be interpreted with caution and within the context of this work.

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Section: Anestheticsmentioning

confidence: 40%

Long-term trend in patch test reactions: a 32-year statistical overview (1970–2002), part II

Tudela

MacPherson

Maibach

2008

Cutaneous and Ocular Toxicology

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“…23 Adding more confusion to the scenario is the possibility of cross-sensitization. Klein et al 24 reported a patient who had a delayed-type reaction to mepivacaine. Patch testing results were positive for lidocaine and mepivacaine sensitivities, but the lidocaine patch revealed a more exuberant reaction.…”

Section: Patch Test Clinic Patientsmentioning

confidence: 99%

“…The patient's medical history was notable for exposure to lidocaine. 24 Our first patient reported a medical history positive for a pruritic rash days after an injection of local anesthetic for both dental surgery and breast biopsy. Her patch test result to lidocaine was strongly positive, and intradermal injection also revealed a pink papular eruption consistent with a delayed-type hypersensitivity reaction.…”

Section: Patch Test Clinic Patientsmentioning

confidence: 99%

Delayed-Type Hypersensitivity to Lidocaine

2003

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“…This report was followed by others [15, 16]. Contact allergy to amide anesthetics is rare and, according to Klein and Gall [17] in 1991, only 18 cases had been reported since these medications began to be used in the 1940s. Most of the delayed-type hypersensitivity reactions take place after a topical application of the drug [18].…”

Section: Discussionmentioning

confidence: 79%

Allergy to lidocaine injections: comparison of patient history with skin testing in five patients

Jenerowicz¹,

Polańska²,

Glińska³

et al. 2014

pdia

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IntroductionTrue allergy to local anesthetics, especially lidocaine, is uncommon. Most adverse reactions to this group of medications are classified as psychomotor, autonomic or toxic. In the case of suspected hypersensitivity to local anesthetics, skin testing is considered to be a useful tool – patch tests and intradermal tests for delayed hypersensitivity and skin prick tests and intradermal tests for immediate reactions. There is a particular need for such a diagnostic procedure, as patients suspected of hypersensitivity to local anesthetic drugs are frequently admitted.AimTo highlight the problem of hypersensitivity to local anesthetics on the basis of authors’ own experience and literature data.Material and methodsWe present cases of 5 patients referred to the clinic by their dentists with a suspicion of allergy to local anesthetics, four to lidocaine and 1 to articaine.ResultsIntradermal tests were positive in 1 out of 5 subjects, with a concomitant episode of urticaria. In 1 patient we obtained a doubtful result of intradermal tests. Skin prick tests and patch tests were negative in all cases. In 2 cases we performed an incremental challenge test also with a negative result.ConclusionsIt has to be emphasized that, although rare, consequences of true allergy to local anesthetics can be serious considering a patient's future management and therapy. That is why this diagnosis may be crucial.

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Type IV allergy to amide‐type local anesthetics

Cited by 49 publications

References 6 publications

Long-term trend in patch test reactions: a 32-year statistical overview (1970–2002), part II

Long-term trend in patch test reactions: a 32-year statistical overview (1970–2002), part II

Delayed-Type Hypersensitivity to Lidocaine

Allergy to lidocaine injections: comparison of patient history with skin testing in five patients

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