Type of pain, pain-associated complications, quality of life, disability and resource utilisation in chronic pancreatitis: a prospective cohort study

Abstract

This is the largest study ever conducted of pain in CP. These findings suggest that the temporal nature of pain is a more important determinant of health-related QOL and healthcare utilisation than pain severity. In contrast to previous studies, the pain associated with CP was not found to change in quality over time. These results have important implications for improving our understanding of the mechanisms underlying pain in CP and for the goals of future treatments and interventions.

Induction of chronic pancreatitis by pancreatic duct ligation activates BMP2, apelin, and PTHrP expression in mice

“…inflammation; fibrosis; interaction; cross talk; network; signaling CHRONIC PANCREATITIS (CP) is a persistent inflammatory disease characterized by parenchyma degeneration, pain, and enhanced vulnerability for development of pancreatic cancer (4,27,48). Although utilization of experimental models has helped identify molecular mechanisms linked to development of CP (19,32,41,47), significant gaps persist in our knowledge of endogenous factors that function to either inhibit or amplify the inflammatory-fibrosis cascade (7,9,41), a key component of the CP disease process.…”

Adrenergic signaling mediates mechanical hyperalgesia through activation of P2X3 receptors in primary sensory neurons of rats with chronic pancreatitis

“…Sensitization of P2X3Rs, which was likely mediated by adrenergic signaling in primary sensory neurons, contributes to pancreatic pain, thus identifying a potential target for treating pancreatic pain caused by inflammation. chronic pancreatitis; dorsal root ganglion; purinergic receptors; norepinephrine; protein kinase A CHRONIC PANCREATITIS (CP) is a progressive inflammatory disorder characterized by repeated attacks of abdominal pain, fibrosis, and destruction of the glandular pancreas (15,29,39). Pain is a cardinal feature of CP, featured as burning, intermittent, and shooting pain (13).…”

Chronic pancreatitis. Multicentre prospective data collection and analysis by the Hungarian Pancreatic Study Group

“…In our cohort, 68% of the patients suffered from pain; in other studies, this varies between 80% and 96% [29][30][31][32].…”