Type of paternal sperm exposure before pregnancy and the risk of preeclampsia: A systematic review

Mascio, Daniele Di; Saccone, Gabriele; Bellussi, Federica; Vitagliano, Amerigo; Berghella, Vincenzo

doi:10.1016/j.ejogrb.2020.05.065

Cited by 9 publications

(6 citation statements)

References 30 publications

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“…Other risk factors are based on an emerging number of factors that may increase risk of preeclampsia. Cohabitation of >12 months 94 and smoking 95,96 have an inverse association with preeclampsia risk. All estimates are unadjusted unless specified as aHR/ aOR.…”

Section: Postpartum Hypertension and Postpartum Preeclampsiamentioning

confidence: 96%

Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association

Garovic¹,

Dechend²,

Easterling³

et al. 2022

Hypertension

272

174

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Hypertensive disorders of pregnancy (HDP) remain one of the major causes of pregnancy-related maternal and fetal morbidity and mortality worldwide. Affected women are also at increased risk for cardiovascular disease later in life, independently of traditional cardiovascular disease risks. Despite the immediate and long-term cardiovascular disease risks, recommendations for diagnosis and treatment of HDP in the United States have changed little, if at all, over past decades, unlike hypertension guidelines for the general population. The reasons for this approach include the question of benefit from normalization of blood pressure treatment for pregnant women, coupled with theoretical concerns for fetal well-being from a reduction in utero-placental perfusion and in utero exposure to antihypertensive medication. This report is based on a review of current literature and includes normal physiological changes in pregnancy that may affect clinical presentation of HDP; HDP epidemiology and the immediate and long-term sequelae of HDP; the pathophysiology of preeclampsia, an HDP commonly associated with proteinuria and increasingly recognized as a heterogeneous disease with different clinical phenotypes and likely distinct pathological mechanisms; a critical overview of current national and international HDP guidelines; emerging evidence that reducing blood pressure treatment goals in pregnancy may reduce maternal severe hypertension without increasing the risk of pregnancy loss, high-level neonatal care, or overall maternal complications; and the increasingly recognized morbidity associated with postpartum hypertension/preeclampsia. Finally, we discuss the future of research in the field and the pressing need to study socioeconomic and biological factors that may contribute to racial and ethnic maternal health care disparities.

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Section: Postpartum Hypertension and Postpartum Preeclampsiamentioning

confidence: 96%

Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association

Garovic¹,

Dechend²,

Easterling³

et al. 2022

Hypertension

272

174

View full text Add to dashboard Cite

show abstract

“…Our hierarchical search strategy identified 41 studies to support or refute determinants of pre‐eclampsia: two umbrella reviews that supported 25 risk factors, 11,12 14 systematic reviews or meta‐analyses covering an additional 15 risk factors, 48–61 and 25 large observational studies supporting 28 additional risk factors 62–86 . Our strategy identified no evidence meeting our criteria for ten risk factors.…”

Section: Resultsmentioning

confidence: 99%

Risk factors for pre‐eclampsia in clinical practice guidelines: Comparison with the evidence

Elawad

Scott

Bone

et al. 2022

BJOG

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“…In addition to the spermatozoa, seminal fluid contains a variety of nutrients (fructose, citric acid), microbes, and proteolytic enzymes that are necessary for sperm survival and the successful fertilization of the oocyte [6][7][8]. Numerous studies have demonstrated that the quality of the seminal fluid can influence embryonic implantation, the microbial composition of the intrauterine environment, and placental function [9][10][11][12][13]. Importantly, the placenta is largely a paternally derived organ and is critical for pregnancy maintenance and fetal development [14].…”

Section: Introductionmentioning

confidence: 99%

A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice

Rumph

Rayford

Stephens

et al. 2021

Toxics

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New bronchopulmonary dysplasia is a developmental lung disease associated with placental dysfunction and impaired alveolarization. Risk factors for new BPD include prematurity, delayed postnatal growth, the dysregulation of epithelial-to-mesenchymal transition (EMT), and parental exposure to toxicants. Our group previously reported that a history of paternal toxicant exposure increased the risk of prematurity and low birth weight in offspring. A history of paternal toxicant exposure also increased the offspring’s risk of new BPD and disease severity was increased in offspring who additionally received a supplemental formula diet, which has also been linked to poor lung development. Risk factors associated with new BPD are well-defined, but it is unclear whether the disease can be prevented. Herein, we assessed whether a paternal fish oil diet could attenuate the development of new BPD in the offspring of toxicant exposed mice, with and without neonatal formula feeding. We investigated the impact of a paternal fish oil diet preconception because we previously reported that this intervention reduces the risk of TCDD associated placental dysfunction, prematurity, and low birth weight. We found that a paternal fish oil diet significantly reduced the risk of new BPD in neonatal mice with a history of paternal toxicant exposure regardless of neonatal diet. Furthermore, our evidence suggests that the protective effects of a paternal fish oil diet are mediated in part by the modulation of small molecules involved in EMT.

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Type of paternal sperm exposure before pregnancy and the risk of preeclampsia: A systematic review

Cited by 9 publications

References 30 publications

Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association

Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association

Risk factors for pre‐eclampsia in clinical practice guidelines: Comparison with the evidence

A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice

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