Type-specific persistence and associated risk factors of human papillomavirus infections in women living in central Italy

Sammarco, Michela Lucia; Riccio, Ilenia Del; Tamburro, Manuela; Grasso, G.; Ripabelli, Giancarlo

doi:10.1016/j.ejogrb.2013.01.012

Cited by 40 publications

(58 citation statements)

References 32 publications

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“…19 Research conducted in Italy by Verteramo et al 17 found a Ct frequency of 13.9% among HPV-positive women, as against 5.4% among HPV-negative women; these figures are similarly to our estimates. However, in a recent paper by Sammarco et al, 13 Ct prevalence in HPV-positive women aged 18-63 y without cervical lesions was estimated to be as low as 6.3%, which is about half our figure. Again, the difference observed is very probably due to the different age profiles of the study populations.…”

Section: Discussioncontrasting

confidence: 66%

“…6 In Italy, no nationwide population-based studies on the prevalence of Ct infection have yet been performed; 10 Ct case notification is not mandatory and no screening policy exists. 11 A few ad hoc studies conducted in Italy [11][12][13][14][15][16][17] have found Ct prevalence rates ranging from 1.8-10.4% among sexually active women, depending on the study population and geographic area. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chlamydia trachomatisprevalence and chlamydial/HPV co-infection among HPV-unvaccinated young Italian females with normal cytology

Panatto

Amicizia

Bianchi

et al. 2014

Human Vaccines & Immunotherapeutics

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Section: Discussioncontrasting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Chlamydia trachomatisprevalence and chlamydial/HPV co-infection among HPV-unvaccinated young Italian females with normal cytology

Panatto

Amicizia

Bianchi

et al. 2014

Human Vaccines & Immunotherapeutics

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“…Furthermore, investigation of sexual behaviors is difficult owing to the conservative Korean culture that limits truthful responses and the provision of information on sexual behaviors. A follow-up study conducted in Italy found no significant association between persistent HPV infection and a history of STDs; however, the association between Chlamydia trachomatis or Mycoplasma spp infection and HPV persistence could not be investigated because of the low detection rate of these organisms in the study population [37]. Korean women also had very low C. trachomatis prevalence, with an age-standardized prevalence of 4.3% [38].…”

Section: Discussionmentioning

confidence: 85%

Synergistic Effect of Viral Load and Alcohol Consumption on the Risk of Persistent High-Risk Human Papillomavirus Infection

Seo

Kim

et al. 2014

PLoS ONE

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PurposeThis prospective study aimed to examine the combined effect of viral load and alcohol consumption on the risk of persistent high-risk (HR) human papillomavirus (HPV) infection.MethodsAmong women undergoing health screening between 2002 and 2011 at the National Cancer Center, 284 and 122 women with HR-HPV infection and cytological findings of low-grade squamous intraepithelial or lower-grade lesions were followed up for 1 and 2 years, respectively. Multivariate logistic regression analysis was performed, and the relative excess risk due to interaction (RERI) and synergy index (S) were calculated.ResultsAmong drinkers, the risks of 1-year (odds ratio [OR] 4.09, 95% confidence interval [CI] 2.05–8.18) and 2-year persistence (OR 8.08, CI 2.36–27.6) were significantly higher for high HPV loads than for low HPV loads; this association was not seen for non-drinkers. The risks for 1-year (OR 4.14, CI 1.89–9.05) and 2-year persistence (OR 6.61, CI 2.09–20.9) were significantly higher in subjects with a high HPV load who were also drinkers than in those who were non-drinkers. A high HPV load together with a longer drinking duration or higher alcohol consumption was associated with increased risks of 1-year (OR 3.07, CI 1.40–6.75 or OR 2.05, CI 0.87–4.83) and 2-year persistence (OR 6.40, CI 1.72–23.8 or OR 4.14, CI 1.18–14.6). The synergistic effect of alcohol consumption and HR-HPV load was stronger on the risk of 2-year persistence (RERI = 3.26, S = 2.38) than on the risk of 1-year persistence (RERI = 1.21, S = 1.63).ConclusionsThe synergistic effect of HR-HPV load and alcohol consumption was associated with the risk of HR-HPV persistence and was stronger for longer-term HR-HPV infection. Limiting alcohol consumption might be an important measure to prevent the development of cervical cancer in women with a high HR-HPV load.

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“…We used narrow and multiple follow-up intervals, allowing us to identify hrHPV infection and clearance more precisely than was possible in previous studies, many of which measured persistence based on the presence of hrHPV at two consecutive time points only, and collected data in intervals of six months to several years. 5,7,8,24–26,13,27–29 . Second, while parametric methods, notably logistic regression to estimate odds ratios, are popular for evaluating hrHPV persistence, AFT models to estimate time ratios had not been implemented to our knowledge in the published literature prior to this work.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, few risk factor analyses have statistically quantified persistence of hrHPV infections using continuous time in number of days or months, rather than a number of time intervals. 12,13 Further, fully parametric methods for longitudinal data have not yet been implemented in the published literature to measure relative time to clearance of hrHPV infection, comparing individuals with and without given risk factors.…”

Section: Introductionmentioning

confidence: 99%

The Role of Chlamydia trachomatis in High-Risk Human Papillomavirus Persistence Among Female Sex Workers in Nairobi, Kenya

Vielot¹,

Hudgens²,

Mugo³

et al. 2015

Sexually Transmitted Diseases

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Background Little is known about risk factors for persistent high-risk HPV (hrHPV) infection in low-income settings, and prior research has not quantified the relative duration of hrHPV infections stratified by risk factors. We compared the duration of hrHPV infection among female sex workers (FSW) by exposure to sexually transmitted infections (STIs), using a highly-sensitive biomarker assay. Methods From 2009–2011, 350 FSW enrolled in this longitudinal study. Every three months, sociodemographic and sexual behavior data were collected via questionnaire, and APTIMA assays were used to detect the rRNA of Chlamydia trachomatis (CT), Neisseria gonorrhea (GC), Trichomonas vaginalis (TV), Mycoplasma genitalium (MG), and mRNA of the E6/E7 oncoproteins expressed by hrHPV. Among 173 FSW who were infected with hrHPV during the observation period, accelerated failure time models estimated time ratios (TR) for duration of hrHPV infection, comparing FSW infected with STIs at baseline to STI-uninfected FSW. Results Median follow-up time was 26.2 months (IQR: 18.8 – 27.5). The median duration of hrHPV infection among all FSW was 9.3 months (95% CI: 9.3, 11.5). The duration of hrHPV infection among FSW infected with CT at baseline was greater than that among FSW who were uninfected (adjusted TR: 1.7, 95% CI: 1.2, 2.6). Among FSW who were co-infected with hrHPV and CT at baseline, the adjusted TR was 3.4 (95% CI: 2.5, 5.4) compared to FSW infected with hrHPV only. No other STI was associated with hrHPV duration. Conclusion Recent or concurrent CT infection was associated with prolonged hrHPV infection among a cohort of Nairobi FSW. Management of CT could reduce risk for hrHPV persistence.

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Type-specific persistence and associated risk factors of human papillomavirus infections in women living in central Italy

Cited by 40 publications

References 32 publications

Chlamydia trachomatisprevalence and chlamydial/HPV co-infection among HPV-unvaccinated young Italian females with normal cytology

Chlamydia trachomatisprevalence and chlamydial/HPV co-infection among HPV-unvaccinated young Italian females with normal cytology

Synergistic Effect of Viral Load and Alcohol Consumption on the Risk of Persistent High-Risk Human Papillomavirus Infection

The Role of Chlamydia trachomatis in High-Risk Human Papillomavirus Persistence Among Female Sex Workers in Nairobi, Kenya

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